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Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Mutations in Wnt genes or Wnt pathway components lead to specific developmental defects, while various human diseases, including cancer, are caused by abnormal Wnt signaling. As currently understood, Wnt proteins bind to receptors of the Frizzled and LRP families on the cell surface. Through several cytoplasmic relay components, the signal is transduced to beta-catenin, which enters the nucleus and forms a complex with TCF to activate transcription of Wnt target genes (see diagrams of the Wnt pathway). | |
This website serves as a resource for members of the Wnt community, providing information on progress in the field, maps on signaling pathways, and methods. The page on reagents lists many resources generously made available to and by the Wnt community. There are usually several Wnt meetings per year (meetings announced for 2013 and 2014). Wnt signaling is discussed in many reviews, listed here and in a recent book. |  |
Wnt | Frizzled, SFRP | Dishevelled |
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TCF |
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| Axin | Other genes |
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Wnt Target genes | Diseases/Other systems |
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