Signaling components as Wnt targets

 

Wnt signaling pathway components

Wnt signaling can promote the expression of several Wnt pathway components, indicating that feedback control is a key feature of Wnt signaling regulation.

Target Gene

Effect of Wnt signal on target gene expression

Effect of changes in target gene expression on Wnt pathway

Target gene interacts with:

Reference

Fz

Down

Inactivate

Wnt

Muller 1999

Dfz2

Down

Inactivate

Wnt

Cadigan 1998

Dfz3

Up

Activate

Wnt

Sato A, 1999

Fz7

up


Wnt

Willert 2002

Arrow/LRP

Down

Inactivate

Wnt

Wehrli et al, 2000

Dickkopf Up Inactivate LRP
Niida. 2004
Gonzalez-Sancho 2004
Chamorro 2004

Dally (HSPG)

Down


Wnt

Baeg, 2000

Wingful/notum

Up

Inactivate

HSPG?

Giraldez et al. 2002

naked

Up

Inactivate

Dsh

Rousset et al, 2001

nemo Up Inactivate TCF Zeng , 2004

Axin2

Up

Inactivate

β-catenin

Yan, 2001
Lustig, 2002
Jho, 2002

b-TCRP

Up

Inactivate

β-catenin

Spiegelman 2000

TCF1 (dn)

Up

Inactivate

TCF

Roose 1999

LEF1

Down

Activate

β-catenin

Hovanes, 2001