Karl Deisseroth, M.D., Ph.D.

E-mail: deissero at stanford.edu

Associate Professor of Bioengineering
Associate Professor of Psychiatry and Behavioral Sciences

318 Campus Drive West
Clark Center W083
Department of Bioengineering
Stanford University
Stanford, CA 94305

Education
2000 Ph.D. in Neuroscience, Stanford University
2000 M.D., Stanford University
1992 A.B. in Biochemical Sciences, Harvard College

Professional Positions
01/09 - Present Associate Professor of Bioengineering and Psychiatry, Stanford Univ
01/06 - Present Diplomate, American Board of Psychiatry and Neurology
01/05 - 12/08 Assistant Professor of Bioengineering and Psychiatry, Stanford Univ
07/01 - 12/04 Postdoctoral Fellow w/ Robert. C. Malenka MD PhD, Stanford Univ
06/00 - 06/04 MD internship, licensure, and residency, Stanford Univ
09/92 - 06/00 Medical Scientist Training Program with Richard W. Tsien, DPhil, Stanford Univ

Honors and Awards
2009 Early Career Investigator, Howard Hughes Medical Institute
2008 Schuetze Prize in Neurobiology, Columbia University
2008 Lawrence C. Katz Price in Neurobiology
2008 Brilliant 10 Award, Popular Science
2008 William M. Keck Foundation Medical Research Award
2007 MIT Technology Review: Top 10 Technologies (TR10) of 2007 Award
2007 McKnight Foundation Scholar Award
2006 Presidential Early Career Award for Scientists and Engineers
2005 American Psychiatric Institute for Research and Education Young Faculty Award
2006 Robert H. Ebert Clinical Scholar Award
2005 Whitehall Foundation Award
2005 Klingenstein Fellowship Award
2005 NIH Director's Pioneer Award
2005 McKnight Technological Innovations in Neuroscience Award
2005 Coulter Foundation Early Career Translational Research Award
2005 Office of Technology Licensing Research Incentive Grant
2004 Rockefeller Brothers Fund Culpeper Scholar Award
2004 American Psychiatric Association Lilly Resident Research Award
2003 West Coast College of Biological Psychiatry Resident Award

Professional Society Memberships
2005 - Present Biomedical Engineering Society
2005 - Present American College of Neuropsychopharmacology
2004 - Present American Psychiatric Association
1993 - Present Society for Neuroscience
Professional Services
Scientific Advisor Michael J Fox Foundation (Non-profit)
Scientific Advisor Kinetics Foundation for Parkinson's Research (Non-profit)
Member Defense Sciences Research Council, DSRC/DARPA
Member NIH Molecular Neurogenetics chartered study section (MNG)
Lecturer Cold Spring Harbor Laboratory and Woods Hole Optogenetics Course (2007, 2008)
Invited Talks
2006 NIMH Director's Innovation Seminar Series; 2006 NIH Neural Interfaces Workshop; 2007 Presidential Lecture, Association for Chemoreception Sciences; 2007 CSHL Lecture in Imaging Neurons and Neural Activity; 2007 Brandeis; 2007 Yale; 2007 UCSF; 2007 Woods Hole; 2007 McKnight (Aspen); 2007 Harvard College; 2007 MIT; 2007 Max-Planck Institutes Heidelberg, Bonn; 2007 ACNP; 2007 International Neuromodulation Society; 2008 Genetics Society of America; 2008 Salk/Nature/Ipsen Biological Complexity; 2008 Cosyne; 2008 MGH, Harvard; 2008 Days of Molecular Medicine, Karolinska Institutet; 2008 World Economic Forum, Davos; 2008 MIT; 2008 FENS (Geneva); 2008 International Congress of Genetics, Berlin; 2008 Bordeaux; 2008 Presidential Lecture ACNP; 2008 Weizmann Institute, Israel.

Publications
  1. Sohal VS, Zhang F, Yizhar O, Deisseroth K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature, April 26, 2009. (advanced online publication).
  2. Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, April 26, 2009.(advanced online publication).
  3. Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning. Science. April 23, 2009.(advanced online publication).
  4. Zimmermann G, Wang LP, Vaughan AG, Manoli DS, Zhang F, Deisseroth K, Baker BS, Scott MP. Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. PLoS ONE 2009; 4(4):e5100.
  5. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Optical deconstruction of parkinsonian neural circuitry. Science 2009 17 Apr; 324(5925):354-9.
  6. Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Temporally precise in vivo control of intracellular signalling. Nature 2009 23 Apr; 458, 1025-1029
  7. Berndt A, Yizhar O, Gunaydin LA, Hegemann P, Deisseroth K. Bi-stable neural state switches. Nature Neuroscience 2008; 12:229-234.
  8. Zhao S, Cunha C, Zhang F, Liu Q, Gloss B, Deisseroth K, Augustine GJ, Feng G. Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biology, 36:141-54.
  9. Douglass AD, Kraves S, Deisseroth K, Schier AF, Engert F. Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Current Biology. Aug 5, 2008; 18:1133-7.
  10. Gradinaru V, Thompson KR, Deisseroth K. eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Brain Cell Biology, 36:129-39.
  11. Hu E, Airan R, Vijaykuman R, Deisseroth K. Brain circuit dynamics. American Journal of Psychiatry, 165:800.
  12. Zhang F, Prigge M, Beyriere F, Tsunoda SP, Mattis J, Yizhar O, Hegemann O, Deisseroth K. Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nature Neuroscience 11:631-3.
  13. Schneider MB, Gradinaru V, Zhang F, Deisseroth K. Controlling neuronal activity. American Journal of Psychiatry, 165:562.
  14. Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, Schneider MB, Deisseroth K. Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci. 2007 Dec 26;27(52):14231-8.
  15. Airan RD, Hu ES, Vijaykumar R, Roy M, Meltzer LA, Deisseroth K. Integration of light-controlled neuronal firing and fast circuit imaging. Curr Opin Neurobiol. 2007 Dec 17.
  16. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD. Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol. 2007 Dec 18;17(24):2105-16. Epub 2007 Nov 29.
  17. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature. 2007 Nov 15;450(7168):420-4.
  18. Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Circuit-breakers: optical technologies for probing neural signals and systems. Nat Rev Neurosci. 2007 Aug;8(8):577-81.
  19. Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science. 2007 Aug 10;317(5839):819-23.
  20. Aravanis A, Wang LP, Zhang F, Meltzer L, Mogri M, Schneider MB, Deisseroth K. An optical neural interface. J. Neural Eng. 2007 Sept; 4:S143-S156.
  21. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD, Feng G. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron. 2007 Apr 19;54(2):205-18.
  22. Wang H, Peca J, Matsuzaki M, Matsuzaki K, Noguchi J, Qiu L, Wang D, Zhang F, Boyden E, Deisseroth K, Kasai H, Hall WC, Feng G, Augustine GJ. High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8143-8.
  23. Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PG, Bamberg E, Nagel G, Gottschalk A, Deisseroth K. Multimodal fast optical interrogation of neural circuitry. Nature. 2007 Apr 5;446(7136):633-9.
  24. Deisseroth K, Feng G, Majewska AK, Miesenbock G, Ting A, Schnitzer MJ. Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci. 2006 Oct 11;26(41):10380-6.
  25. Zhang F, Wang LP, Boyden ES, Deisseroth K. Channelrhodopsin-2 and optical control of excitable cells. Nat Methods. 2006 Oct;3(10):785-92.
  26. Meltzer LA, Yabaluri R, Deisseroth K. A role for circuit homeostasis in adult neurogenesis. Trends Neurosci. 2005 Dec;28(12):653-60.
  27. Deisseroth K, Malenka RC. GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling. Neuron. 2005 Sep 15;47(6):775-7.
  28. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005 Sep;8(9):1263-8.
  29. Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron. 2004 May 27;42(4):535-52.
  30. Deisseroth K, Mermelstein PG, Xia H, Tsien RW. Signaling from synapse to nucleus: the logic behind the mechanisms. Curr Opin Neurobiol. 2003 Jun;13(3):354-65.
  31. Deisseroth K, Tsien RW. Abstract Dynamic multiphosphorylation passwords for activity-dependent gene expression. Neuron. 2002 Apr 11;34(2):179-82.
  32. Mermelstein PG, Deisseroth K, Dasgupta N, Isaksen AL, Tsien RW. Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15342-7. Erratum in: Proc Natl Acad Sci U S A 2002 Mar 19;99(6):4132-3.
  33. Wu GY, Deisseroth K, Tsien RW. Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2808-13.
  34. Wu GY, Deisseroth K, Tsien RW.Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat Neurosci. 2001 Feb;4(2):151-8.
  35. Mermelstein PG, Bito H, Deisseroth K, Tsien RW. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. J Neurosci. 2000 Jan 1;20(1):266-73.
  36. Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 1999 Oct 14;401(6754):703-8.
  37. Zuhlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature. 1999 May 13;399(6732):159-62.
  38. Deisseroth K, Heist EK, Tsien RW. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Nature. 1998 Mar 12;392(6672):198-202.
  39. Bito H, Deisseroth K, Tsien RW. Ca2+-dependent regulation in neuronal gene expression. Curr Opin Neurobiol. 1997 Jun;7(3):419-29.
  40. Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell. 1996 Dec 27;87(7):1203-14.
  41. Deisseroth K, Bito H, Tsien RW. Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Neuron. 1996 Jan;16(1):89-101.
  42. Deisseroth K, Bito H, Schulman H, Tsien RW. Synaptic plasticity: A molecular mechanism for metaplasticity. Curr Biol. 1995 Dec 1;5(12):1334-8.
Deisseroth Lab • Stanford University • 318 Campus Drive West • Clark Center W080 • Stanford • California 94305