1100s Variolation (inoculation with live virus) for smallpox first reported in China1721 Variolation introduced into Great Britain by Lady Mary Wortley Montagu
1796 Edward Jenner inoculated James Phipps with cowpox, and calls the procedure vaccination
vacca = cow, in Latin)1870 Louis Pasteur creates the first live attenuated bacterial vaccine (chicken cholera)
1884 Pasteur creates the first live attenuated viral vaccine (rabies)
1885 Pasteur first uses rabies vaccine in a human
1909 Calmet and Guerine create BCG, the first live attenuated bacterial vaccine for humans
1933 Goodpasture describes a technique for viral culture in hen's eggs
1949 Enders and colleagues isolate Lansing Type II poliovirus in human cell line
1954 Enders isolates measles virus
1955 Inactivated polio vaccine licensed
1961 Human diploid cell line developed
1963 Measles vaccine licensed
Trivalent oral polio vaccine licensed1966 World Health Assembly calls for global smallpox eradication
1977 Last indigenous case of smallpox (Somalia)
1979 Last wild-virus polio transmission in the U.S.
1986 Licensure of first recombinant vaccine (hepatitis B)
1989 Two-dose measle vaccine recommendation
1990 Licensure of first polysaccharide conjugate vaccine (Haemophilus influenzae type b)
1991 Last wild-virus polio case in the Western Hemisphere
Universal infant hepatitis B vaccination recommended1994 Polio elimination certified in the Americas
1995 Varicella vaccine licensed
1996 Acellular pertussis vaccine licensed for infants
1997 Sequential polio vaccination recommended
1998 Rotavirus vaccine licensed in U.S.
1999 and beyond Global eradication of measles? Polio? HIV?
adapted from Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book), 4th Edition
http://www.cdc.gov/nip/publications/pink/e&p_vpd.htm
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