Publications

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1986
Rijsewijk FA, van Lohuizen M, van Ooyen A, Nusse R. "Construction of a retroviral cDNA version of the int-1 mammary oncogene and its expression in vitro." Nucleic Acids Res. 1986;14:693-702. Abstract
Lens PF, Altena B, Nusse R. "Expression of c-sis and platelet-derived growth factor in in vitro-transformed glioma cells from rat brain tissue transplacentally treated with ethylnitrosourea." Mol Cell Biol. 1986;6:3537-3540. Abstract
1987
Mester J, Wagenaar E, Sluyser M, Nusse R. "Activation of int-1 and int-2 mammary oncogenes in hormone-dependent and -independent mammary tumors of GR mice." J Virol. 1987;61:1073-1078. Abstract
Rijsewijk F, Schuermann M, Wagenaar E, Parren P, Weigel D, Nusse R. "The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless." Cell. 1987;50:649-657. Abstract
Sonnenberg A, van Balen P, Hilgers J, Schuuring E, Nusse R. "Oncogene expression during progression of mouse mammary tumor cells; activity of a proviral enhancer and the resulting expression of int-2 is influenced by the state of differentiation." EMBO J. 1987;6:121-125. Abstract
Rijsewijk F, van Deemter L, Wagenaar E, Sonnenberg A, Nusse R. "Transfection of the int-1 mammary oncogene in cuboidal RAC mammary cell line results in morphological transformation and tumorigenicity." EMBO J. 1987;6:127-131. Abstract
van de Vijver M, van de Bersselaar R, Devilee P, Cornelisse C, Peterse J, Nusse R. "Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene." Mol Cell Biol. 1987;7:2019-2023. Abstract
1988
Nusse R. "The activation of cellular oncogenes by proviral insertion in murine mammary cancer." Cancer Treat Res. 1988;40:283-306.
Van de Vijver MJ, Mooi WJ, Peterse JL, Nusse R. "Amplification and over-expression of the neu oncogene in human breast carcinomas." Eur J Surg Oncol. 1988;14:111-114. Abstract
Van de Vijver MJ, Mooi WJ, Wisman P, Peterse JL, Nusse R. "Immunohistochemical detection of the neu protein in tissue sections of human breast tumors with amplified neu DNA." Oncogene. 1988;2:175-178. Abstract
Van de Vijver MJ, Peterse JL, Mooi WJ, et al. "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." N Engl J Med. 1988;319:1239-1245. Abstract
Nusse R. "The int genes in mammary tumorigenesis and in normal development." Trends Genet. 1988;4:291-295.
1989
Theunissen HJ, Paardekooper M, Maduro LJ, Michalides RJ, Nusse R. "Phorbol ester-inducible T-cell-specific expression of variant mouse mammary tumor virus long terminal repeats." J Virol. 1989;63:3466-3471. Abstract
Schuuring E, van Deemter L, Roelink H, Nusse R. "Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells." Mol Cell Biol. 1989;9:1357-1361. Abstract
van den Heuvel M, Nusse R, Johnston P, Lawrence PA. "Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication." Cell. 1989;59:739-749. Abstract
1990
Nusse R. "The int genes in mouse mammary tumorigenesis and in normal development." Ciba Found Symp. 1990;150:212-222. Abstract
Schuuring E, van der Leede BJ, Willems R, et al. "Differentiation-dependent expression of provirus-activated int-1 oncogene in clonal cell lines derived from a mouse mammary tumor." Oncogene. 1990;5:459-465. Abstract
van Leeuwen F, Van de Vijver MJ, Lomans J, et al. "Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies." Oncogene. 1990;5:497-503. Abstract
Nusse R, Theunissen H, Wagenaar E, et al. "The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus." Mol Cell Biol. 1990;10:4170-4179. Abstract
Roelink H, Wagenaar E, Lopes da Silva S, Nusse R. "Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain." Proc Natl Acad Sci U S A. 1990;87:4519-4523. Abstract
1991
Nusse R. "Insertional mutagenesis in mouse mammary tumorigenesis." Curr Top Microbiol Immunol. 1991;171:43-65.
Van de Vijver MJ, Nusse R. "The molecular biology of breast cancer." Biochim Biophys Acta. 1991;1072:33-50.
Nusse R, Brown A, Papkoff J, et al. "A new nomenclature for int-1 and related genes: the Wnt gene family." Cell. 1991;64:231.
Roelink H, Nusse R. "Expression of two members of the Wnt family during mouse development–restricted temporal and spatial patterns in the developing neural tube." Genes Dev. 1991;5:381-388. Abstract
1992
Salinas PC, Nusse R. "Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres." Mech Dev. 1992;39:151-160. Abstract