Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.
Submitted by admin on Thu, 10/14/2010 - 22:44
| Title | Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene. |
| Publication Type | Journal Article |
| Year of Publication | 1987 |
| Authors | van de Vijver M, van de Bersselaar R, Devilee P, Cornelisse C, Peterse J, Nusse R |
| Journal | Mol Cell Biol |
| Volume | 7 |
| Pagination | 2019–2023 |
| Date Published | May |
| ISSN | 0270-7306 (Print); 0270-7306 (Linking) |
| Abstract | We investigated alterations in the structure and expression of oncogenes in mammary tumors and mammary tumor-derived cell lines. In 16 of 95 samples, we detected amplification of the human neu oncogene, also known as c-erB-2, accompanied by overexpression in the tumors from which intact RNA could be isolated. In 10 of these DNAs, the linked oncogene c-erbA was also amplified, whereas another gene on human chromosome 17, p53, was present in normal copy numbers. Overexpression of c-erbA could not be detected in the tumors analyzed. The relatively high frequency of neu amplification points to a functional role in human breast cancer. Coamplification of the c-erbA oncogene could contribute to this disease as well but is most likely fortuitous. |
