@article {cite-key, title = {Transient expression of the proto-oncogene int-1 during differentiation of P19 embryonal carcinoma cells.}, journal = {Mol Cell Biol}, volume = {9}, number = {3}, year = {1989}, month = {Mar}, pages = {1357{\textendash}1361}, address = {Division of Molecular Biology, Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Amsterdam.}, abstract = {In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development.}, issn = {0270-7306 (Print); 0270-7306 (Linking)}, author = {Schuuring, E and van Deemter, L and Roelink, H and Nusse, R} }