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-====== Can We Identify Cellular Pathways Implicated in Cancer Using Gene Expression Data? ======
-===== Motivation =====
-The cancer state of a cell is characterized by
-alterations of important cellular processes such as
-cell proliferation, apoptosis, DNA-damage repair,
-etc. The expression of genes associated with cancer
-related pathways, therefore, may exhibit differences
-between the normal and the cancerous states. We
-explore various means to find these differences.
-===== Results =====
-We analyze 6 different pathways (p53, Ras, Brca, DNA
-damage repair, NFκb and β-catenin) and 4 different
-types of cancer: colon, pancreas, prostate and
-kidney. Our results are found to be mostly consistent
-with existing knowledge of the involvement of these
-pathways in different cancers. Our analysis
-constitutes proof of principle that it may be possible
-to predict the involvement of a particular pathway in
-cancer or other diseases by using gene expression
-data. Such method would be particularly useful for
-the types of diseases where biology is poorly
-understood.