Reactome — A Curated Knowledgebase of Biological Pathways
Reactome — A Curated Knowledgebase of Biological Pathways
About
The Reactome project is a collaboration among Cold Spring Harbor Laboratory, The European Bioinformatics Institute, and The Gene Ontology Consortium to develop a curated resource of core pathways and reactions in human biology. The information in this database is authored by biological researchers with expertise in their fields, maintained by the Reactome editorial staff, and cross-referenced with the sequence databases at NCBI, Ensembl and UniProt, the UCSC Genome Browser, HapMap, KEGG (Gene and Compound), ChEBI, PubMed and GO.
In addition to curated human events, inferred orthologous events in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli are also available. A description of Reactome has been published in Genome Biology.
Reactome is a free on-line resource, and Reactome software is open-source.
March 12, 2008: Version 24 Released
New additions to curated content include the pathway topics: Signaling by VEGF, Metabolism of nitric oxide, and MicroRNA biogenesis. The pathway topics updated with new curated events include: Apoptosis — Cleavage reactions, Gene expression — Generic transcription pathway, Hemostasis — Tie2 and PECAM events, Immune signaling — TCR cascade, Energy metabolism — PDC regulation, Membrane Trafficking — COP II mediated events, Post translational modifications — Hypusine synthesis, EGFR signaling — PLC-gamma and Grb2 mediated downstream events.
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