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Gaurav Krishnamurthy
Mechnical Engineering
Bio-X
Graduate Student Fellowships 2008/2009
Bio-X Medronic Fellow
Profs. D. Craig Miller (Cardiothoracic Surgery) and Ellen Kuhl (Mechanical Engineering)
Mitral valve disease affects ~3 million adults each year in the United States. Surgical valve repair is preferred, but valve replacement can be required. Replacement involves implantation of a mechanical or tissue valve, which is associated with anticoagulation/thromboembolic complications and less than ideal durability, respectively. To overcome these limitations, a currently important research goal is to create bioengineered autologous tissue valves. A key component of this thrust is to understand more completely the structure and function of native valves. Using radiopaque marker technology and inverse finite element analysis, Gaurav has quantified, for the first time, the material parameters of the anterior mitral leaflet in the beating heart. |
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