Myb Genes and Human Cancer

davinici man

Acute Lymphocytic Leukemia (T-ALL) (~15%)         
Duplication or translocation of C-MYB/MYB

Adenoid Cystic Carcinoma (>60%)
Translocation of C-MYB/MYB

Diffuse Pediatric Cerebral Gliomas (~25%)
Duplication/truncation of C-MYB/MYB or A-MYB/MYBL1

Breast Cancer
Increased B-MYB /MYBL2 => poor prognosis (ONCOTYPE DX)

Myeloid Dysplasia (>60%)
Haploinsufficiency of B-MYB/MYBL2