Arches. Photo by Daniel Chia
HOPES: Huntington's Outreach Project for Education, at Stanford
Nov
13
2010

anticipation

A genetic phenomenon where a disease increases in severity in successive generations, and children can have a more severe form of a disease than their parents. A pattern of anticipation is often observed in trinucleotide repeat disorders. For example, in HD children often have earlier an age of onset and experience a more rapid development of the disease.