My research focuses on protein kinase regulation of signaling pathways involved in cell fate and cancer. Specific areas of investigation include how kinases alter Hedgehog signaling, transcription factor function, hair follicle development, and basal cell carcinoma. Protein kinases are essential to many signaling processes and serve as reversible switches that phosphorylate specific substrates. Spatial and temporal control of kinases is achieved through differential localization, substrate specificity, and modulation of the catalytic domain. Kinases provide attractive therapeutic targets in cancer as they are integral to cell proliferation and invasion. My work has discovered novel roles of kinases in signaling pathways controlling cell fate specification of neural stem cells, hair follicles, and basal cell carcinoma. How kinases achieve these diverse functions are an ongoing area of investigation.