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- | ====== Can We Identify Cellular Pathways Implicated in Cancer Using Gene Expression Data? ====== | ||
- | ===== Motivation ===== | ||
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- | The cancer state of a cell is characterized by | ||
- | alterations of important cellular processes such as | ||
- | cell proliferation, apoptosis, DNA-damage repair, | ||
- | etc. The expression of genes associated with cancer | ||
- | related pathways, therefore, may exhibit differences | ||
- | between the normal and the cancerous states. We | ||
- | explore various means to find these differences. | ||
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- | ===== Results ===== | ||
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- | We analyze 6 different pathways (p53, Ras, Brca, DNA | ||
- | damage repair, NFκb and β-catenin) and 4 different | ||
- | types of cancer: colon, pancreas, prostate and | ||
- | kidney. Our results are found to be mostly consistent | ||
- | with existing knowledge of the involvement of these | ||
- | pathways in different cancers. Our analysis | ||
- | constitutes proof of principle that it may be possible | ||
- | to predict the involvement of a particular pathway in | ||
- | cancer or other diseases by using gene expression | ||
- | data. Such method would be particularly useful for | ||
- | the types of diseases where biology is poorly | ||
- | understood. |