VH4-34 gene derived mAbs and B lymphocytes
Our laboratory is currently studying the effects of VH4-34 gene derived mAbs on human B lymphocytes. These mAbs induce rapid B cell death with pore formation on the cell membrane.
Laboratory Publications
- Bhat NM, Bieber MM, Stevenson FK, Teng NNH. Rapid cytotoxicity of human B lymphocytes induced by VH4-34 (VH4.21) gene encoded monoclonal antibodies. Clin. Exp. Immunol. 1996; 105:183-190.
- Bhat NM, Mithal A, Bieber MM, Herzenberg LA, Teng NNH. Human CD5+ B Lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy. J. Reprod. Immunol. 1995; 28:53-60.
- Reijnart RM, Bieber MM, Teng NNH. FACS analysis of peritoneal lymphocytes in Ovarian Cancer and control patients. Immunobiol. 1994; 191:1-8.
- Bhat NM, Bieber MM, Chapman CJ, Stevenson FK, Teng NNH. Human antilipid A monoclonal antibodies bind to human B cells and the 'i' antigen on cord red blood cells. J. Immunol. 1993; 151:5011-5021.
- Bhat NM, Kantor AB, Bieber MM, Stall AM, Herzenberg LA, Teng NNH. The ontogeny and functional characteristics of human B-1 (CD5+) cells. Int. Immunol. 1992; 4:243-252.
Goals
How cell membrane pores are formed and what the VH4-34 mAb and B cell interaction effect the immune system