Cancer Biology (CBIO101)
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Experimental
approaches to understanding the origins, diagnosis, and treatment of
cancer. Focus on key experiments and discoveries with emphasis on
genetics, molecular biology, and cell biology. Not just
"what we know", but rather "how we know what we think we
know". Topics covered
include carcinogens, tumor virology, oncogenes, tumor suppressor genes,
cell cycle regulation, angiogenesis, invasion and metastasis, cancer
genomics, cancer epidemiology, and cancer therapy. The course is
designed for upper level undergraduates majoring in Biological Sciences
or Human Biology. Recommended Textbook: "The Biology of Cancer" by Robert Weinberg (Garland Science). Note: Biosciences graduate students and medical students interested in cancer biology should take CBIO241 instead of this undergraduate course.
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CANCER
BIOLOGY 101-- SYLLABUS FOR SPRING QUARTER 2008-2009 |
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Two
lectures per week ( |
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One
assigned discussion section (90 min TBA) per week either on Friday or
Monday. |
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Week
1 |
Lecture
1 |
31-Mar
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Course
Mechanics; Biology of Cancer |
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Lecture
2 |
2-Apr |
Carcinogens,
Retroviruses, and Viral Oncogenes |
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Section |
Stehelin
D, et al (1976) Nature 260: 170-3. |
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Week
2 |
Lecture
3 |
7-Apr |
Cellular
(Non-Viral) Oncogenes |
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Lecture
4 |
9-Apr |
Tyrosine
Kinases |
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Section |
Lowenstein
EJ, et al (1992) Cell 70: 431-42. |
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Week
3 |
Lecture
5 |
14-Apr |
RAS
Pathway |
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Lecture
6 |
16-Apr |
Chromosome
Translocations and Transgenic Mice |
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Section |
Haupt
Y, et al (1991). Cell 65:
753-63 |
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Week
4 |
Lecture
7 |
21-Apr |
Tumor
Suppressor Genes |
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Lecture
8 |
23-Apr |
RB
and Cell Cycle Control |
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Section |
Cavenee
WK, et al (1983). Nature 305: 779-84. |
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Week
5 |
Lecture
9 |
28-Apr |
P53,
DNA Damage, and Cell Cycle Checkpoints |
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Lecture
10 |
30-Apr |
Multistep
Carcinogenesis |
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Section |
Donehower,
et al (1992). Nature 356: 215 - 221. |
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Midterm
Exam (take home; problem-based) |
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Week
6 |
Lecture
11 |
5-May |
Cell
Growth and Cancer |
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Lecture
12 |
7-May |
Apoptosis
and Cancer |
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Section |
Vaux
DL, et al (1988) Nature 335: 440-2. |
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Week
7 |
Lecture
13 |
12-May |
Nuclear
Receptors |
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Lecture
14 |
14-May |
Telomeres,
Stem Cells, and Cancer |
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Section |
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Quintana, et al (2008) Nature 456: 593 - 599. |
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Week
8 |
Lecture
1 |
19-May |
Genetics
of Human Colon
Cancer |
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Lecture
16 |
21-May |
Hypoxia
and Angiogenesis |
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Section |
van
de Wetering M, et al (2002) Cell 111: 241-50. |
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Week
9 |
Lecture
17 |
26-May |
Invasion
and Metastasis |
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Lecture
18 |
28-May |
Cancer
Therapies, Old and New |
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Section |
Lynch
TJ, et al (2004) N Engl J Med 350: 2129-39. |
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Week
10 |
Lecture
1 |
2-Jun |
Cancer
Epidemiology and Prevention |
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Final Exam (take home; problem-based) Grading: 40% discussion section participation; 30% midterm; 30% final exam. |
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