|
Experimental
approaches to understanding the origins, diagnosis, and treatment of
cancer. Focus on key experiments and discoveries with emphasis on
genetics, molecular biology, and cell biology. Not just
"what we know", but rather "how we know what we think we
know". Topics covered
include carcinogens, tumor virology, oncogenes, tumor suppressor genes,
cell cycle regulation, angiogenesis, invasion and metastasis, cancer
genomics, cancer epidemiology, and cancer therapy. The course is
designed for upper level undergraduates majoring in Biological Sciences
or Human Biology.
Lectures supplemented by weekly discussion sections based on primary
research articles that describe key experiments in the field.
Prerequisites: BIOSCI 41/42, HUMBIO core, or equivalent.
Recommended
Textbook: "The Biology of Cancer" by Robert Weinberg (Garland
Science).
Note:
Biosciences graduate students and medical students interested in cancer biology
should take CBIO241 instead of this undergraduate course.
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CANCER
BIOLOGY 101-- PROVISIONAL SYLLABUS FOR WINTER QUARTER 2011
|
| Two
lectures per week ( 2:15-3:45 Tu/Th in
Room M106, Alway Building, School of Medicine ) |
| One
assigned discussion section (90 min TBA) per week either on Friday
or Monday. |
|
Week
1
|
Lecture
1
|
4-Jan
|
Course
Mechanics; Biology of Cancer
|
|
|
Lecture
2
|
6-Jan
|
Carcinogens,
Retroviruses, and Viral Oncogenes
|
|
|
Section
|
|
Stehelin
D, et al (1976) Nature 260: 170-3.
|
|
Week
2
|
Lecture
3
|
11-Jan
|
Cellular
(Non-Viral) Oncogenes
|
|
|
Lecture
4
|
13-Jan
|
Tyrosine
Kinases
|
|
|
Section
|
|
Lowenstein
EJ, et al (1992) Cell 70: 431-42.
|
|
Week
3
|
Lecture
5
|
18-Jan
|
RAS
Pathway
|
|
|
Lecture
6
|
20-Jan
|
Chromosome
Translocations and Transgenic Mice
|
|
|
Section
|
|
Haupt
Y, et al (1991). Cell 65:
753-63
|
|
Week
4
|
Lecture
7
|
25-Jan
|
Tumor
Suppressor Genes
|
|
|
Lecture
8
|
27-Jan
|
RB
and Cell Cycle Control
|
|
|
Section
|
|
Cavenee
WK, et al (1983). Nature 305: 779-84.
|
|
Week
5
|
Lecture
9
|
1-Feb
|
P53,
DNA Damage, and Cell Cycle Checkpoints
|
|
|
Lecture
10
|
3-Feb
|
Multistep
Carcinogenesis
|
|
|
Section
|
|
Donehower,
et al. (1992). Nature 356: 215 - 221.
|
|
Midterm
Exam (take home; problem-based)
|
|
Week
6
|
Lecture
11
|
8-Feb
|
Cell
Growth and Cancer
|
|
|
Lecture
12
|
10-Feb
|
Apoptosis
and Cancer
|
|
|
Section
|
|
Vaux
DL et al (1988) Nature 335: 440-2.
|
|
Week
7
|
Lecture
13
|
15-Feb
|
Nuclear
Receptors and Cancer
|
|
|
Lecture
14
|
17-Feb
|
Telomeres,
Stem Cells, and Cancer
|
|
|
Section
|
|
Quintana,
et al (2008) Nature 456: 593 - 599.
|
|
Week
8
|
Lecture
15
|
22-Feb
|
Human
Colon Cancer:
Genetics and Epigenetics
|
|
|
Lecture
16
|
24-Feb
|
Hypoxia
and Angiogenesis
|
|
|
Section
|
|
van
de Wetering M, et al (2002) Cell 111: 241-50.
|
|
Week
9
|
Lecture
17
|
1-Mar
|
Invasion
and Metastasis
|
|
|
Lecture
18
|
3-Mar
|
Cancer
Therapies, Old and New
|
|
|
Section
|
|
Lynch
TJ, et al (2004) N Engl J Med 350: 2129-39.
|
|
Week
10
|
Lecture
19
|
8-Mar
|
Cancer
Epidemiology and Prevention
|
|
Optional
in-class review session on March 10.
Final
Exam (take home; problem-based)
Grading:
40% discussion section participation; 30% midterm; 30% final exam.
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|