Philip C. Hanawalt

Selected Publications

(from Hanawalt's laboratory)

• Hanawalt PC "Use of Phosphorous-32 in Microassay for Nucleic Acid Synthesis in E. coli" Science 130:386-387 (1959) - First publication
• Hanawalt PC and Setlow RB "Effect of Monochromatic UV on Macromolecular Synthesis in E. coli" Biochim Biophys Acta 41:283-294 (1960)
• Maaløe O, Hanawalt PC "Thymine deficiency and the normal DNA replication cycle I" J Mol Biol 3:144-155 (1961)
• Hanawalt PC, Maaløe O, Cummings D and Schaecter M "The Normal DNA Replication Cycle II" J Mol Biol 3:156-165 (1961)
• Pettijohn D and Hanawalt PC "Evidence for Repair Replication of Ultraviolet Damaged DNA in Bacteria" J Mol Biol 9:395-410 (1964)
• Hanawalt PC, Haynes R "Repair Replication of DNA in Bacteria: Irrelevance of Chemical Nature of Base Defect" Biochem Biophys Res Comm 19:462-467 (1965)
• Hanawalt PC "The U.V. Sensitivity of Bacteria: Its Relation to the DNA Replication Cycle" Photochem Photobiol 5:1-12 (1966)
• Hanawalt PC, Haynes R "The Repair of DNA" Scientific American 216:36-43 (1967)
• Brunk C, Hanawalt PC "Repair of Damaged DNA in a Eucaryotic Cell: Tetrahymena pyriformis" Science 158:663-664 (1967)
• Smith D, Hanawalt PC "Properties of the Growing Point Region in the Bacterial Chromosome" Biochim Biophys Acta 149:519-531 (1967)
• Hanawalt PC "Cellular Recovery from Photochemical Damage" In Photophysiology Vol IV Chapter 12 pp 203-251 (ed AC Giese) Academic Press, New York (1968)
• Hanawalt PC, Pettijohn DE, Pauling CE, Brunk CF, Smith DW, Kanner LC and Couch JL "Repair Replication of DNA in vivo" Cold Spring Harbor Symposia on Quantitative Biology XXXIII pp 187-194 (1968)
• Haynes RH, Hanawalt PC The Molecular Basis of Life: An Introduction to Molecular Biology (Readings from Scientific American with introductions) WH Freeman & Co., San Francisco (1968)
• Smith KC, Hanawalt PC Molecular Photobiology: Inactivation and Recovery Academic Press, New York (1969)
• Smith DW, Hanawalt PC "Repair Replication of DNA in Ultraviolet Irradiated Mycoplasma laidlawii B" J Mol Biol 46:57-72 (1969)
• Fuchs E, Hanawalt PC "Isolation and Characterization of the DNA Replication Complex from Escherichia coli" J Mol Biol 52:301-322 (1970)
• Cooper PK, Hanawalt PC "Heterogeneity of Patch Size in Repair Replicated DNA in E. coli" J Mol Biol 67:1-10 (1972)
• Edenberg H, Hanawalt PC "Size of Repair Patches in the DNA of Ultraviolet Irradiated HeLa Cells" Biophys Biochim Acta 272:361-372 (1972)
• Nakayama H, Hanawalt PC "Sedimentation Analysis of DNA from Thymine-starved Escherichia coli" J Bact 121:537-547 (1975)
• Hanawalt PC, Setlow R eds "Molecular Mechanisms for the Repair of DNA" Basic Life Sciences Series Vol 5 Part A & B, Plenum Press, New York (1975)
• McKeown M, Kahn M, Hanawalt PC "Thymidine Uptake and Utilization in E. coli: A New Gene Controlling Nucleoside Transport" J Bact 126:814-822 (1976)
• Sarasin AR, Hanawalt PC "Carcinogens Enhance Survival of UV-irradiated Simian Virus 40 in Treated Monkey Kidney Cells: Induction of a Recovery Pathway?" Proc Natl Acad Sci USA 75:346-350 (1978)
• Hanawalt PC, Cooper PK, Ganesan AK, Smith CA "DNA Repair in Bacteria and Mammalian Cells" Ann Review of Biochemistry 48:783-836 (1979)
• Lloyd RS, Hanawalt PC, Dodson ML "Processive Action of T4 Endonuclease V on Irradiated DNA" Nucl Acids Res 8:5113-5127 (1980)
• van Zeeland AA, Smith CA, Hanawalt PC "Sensitive Determination of Pyrimidine Dimers in DNA of UV Irradiated Mammalian Cells: Introduction of T4 Endonuclease V into Frozen and Thawed Cells" Mut Res 82:173-189 (1981)
• Lewis RJ, Hanawalt PC "Ligation of Oligonucleotides by Pyrimidine Dimers - A Missing ‘Link’ in the Origin of Life?" Nature 298:393-396 (1982)
• Zolan ME, Cortopassi GA, Smith CA , Hanawalt PC "Deficient Repair of Chemical Adducts in Alpha DNA of Monkey Cells" Cell 28:613-619 (1982)
• Mansbridge JN, Hanawalt PC "Domain-Limited Repair of DNA in Ultraviolet Irradiated Fibroblasts from Xeroderma Pigmentosum Complementation Group C" In Cellular Responses to DNA Damage, (eds EC Friedberg and BR Bridges) UCLA Symp on Mol and Cellu Biol New Series Vol II pp 195-207 Alan R. Liss, Inc., New York (1983)
• Spivak G, Ganesan AK, Hanawalt PC "Enhanced Transformation of Human Cells by UV-Irradiated pSV2 Plasmids" Mol Cell Biol 4:1169-1171 (1984)
• Nakayama H, Nakayama K, Nakayama R, Irino N, Nakayama Y, Hanawalt PC "Isolation and Genetic Characterization of a Thymineless Death-resistant Mutant of Escherichia coli K-12: Identification of a New Mutation (recQ1) that Blocks the RecF Recombination Pathway" Mol Gen Genet 195:474-480 (1984)
• Bohr VA, Smith CA, Okumoto DS, Hanawalt PC "DNA Repair in an Active Gene: Removal of Pyrimidine Dimers from the DHFR Gene of CHO Cells is Much More Efficient Than in the Genome Overall" Cell 40:359-369 (1985)
• Madhani HD, Bohr VA, Hanawalt PC "Differential DNA Repair in Transcriptionally Active and Inactive Protooncogenes: c-abl and c-mos" Cell 45:417-422 (1986)
• Vos J-M, Hanawalt PC "Processing of Psoralen Adducts in an Active Gene: Repair and Replication of DNA Containing Monoadducts and Interstrand Crosslinks" Cell 50:789-799 (1987)
• Mellon I, Spivak G, Hanawalt PC "Selective Removal of Transcription Blocking DNA Damage from the Transcribed Strand of the Mammalian DHFR Gene" Cell 51:241-249 (1987)
• Defais M, Lesca C, Monsarrat B, Hanawalt PC "Translesion synthesis is the main component of SOS repair in bacteriophage lambda DNA" J Bacteriol 171:4938-4944 (1989)
• Mellon I, Hanawalt PC "Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand" Nature 342:95-98 (1989)
• Scicchitano D, Hanawalt PC "Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: Absence of strand specificity in the dihydrofolate reductase gene" Proc Natl Acad Sci USA 86:3050-3054 (1989)
• Ljungman M, Hanawalt PC "Efficient protection against oxidative DNA damage in chromatin" Molecular Carcinogenesis 5:264-269 (1992)
• Ljungman M, Hanawalt PC "Localized torsional tension in the DNA of human cells" Proc Natl Acad Sci USA 89:6055-6059 (1992)
• Spivak G, Hanawalt PC "Translesion DNA synthesis in the DHFR domain of UV-irradiated CHO cells" Biochemistry 31:6794-6800 (1992)
• Sweder KS, Hanawalt PC "Preferential repair of cyclobutane pyrimidine dimers in the transcribed DNA strand in yeast chromosomes and plasmids is dependent upon transcription" Proc Natl Acad Sci USA 89:10696-10700 (1992)
• Christians FC, Hanawalt PC "Lack of transcription-coupled repair in mammalian ribosomal RNA genes" Biochemistry 32:10512-10518 (1993)
• Donahue BA, Yin S, Taylor J-S, Reines D, Hanawalt PC "Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template" Proc Natl Acad Sci USA 91:8502-8506 (1994)
• Lommel L, Carswell-Crumpton C, Hanawalt PC "Preferential repair of the transcribed DNA strand in the dihydrofolate reductase gene throughout the cell cycle in UV-irradiated human cells" Mutation Research: DNA Repair 336:181-192 (1995)
• Hanawalt PC "Transcription-coupled repair and human disease" Science 266:1957-1958 (1994)
• Hanawalt PC "DNA repair comes of age" Mutation Research: DNA Repair 336:101-113 (1995)
• Eisen, JA, Sweder KS, Hanawalt PC "Evolution of the SNF2 family of proteins: Subfamilies with distinct sequences and functions" Nucl Acids Res 23:2715-2723 (1995)
• Ford JM, Hanawalt PC "Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV-resistance" Proc Natl Acad Sci USA 92:8876-8880 (1995)
• Koehler DR, Hanawalt PC "Recruitment of damaged DNA to the nuclear matrix in hamster cells following ultraviolet irradiation" Nucl Acids Res 24:2877-2884 (1996)
• Satoh MS, Hanawalt PC "TFIIH mediated nucleotide excision repair and initiation of m-RNA transcription in an optimized cell-free DNA repair and RNA transcription assay" Nucl Acids Res 24:3576-3582 (1996)
• Courcelle J, Carswell-Crumpton C, Hanawalt PC "recF and recR are required for the resumption of replication at DNA replication forks in Escherichia coli" Proc Natl Acad Sci USA 94:3714-3719 (l997)
• Liu S-K, Tseng J-N, Shiuan D, Hanawalt PC, "Preferential mutagenesis of lacZ integrated at unique sites in the Escherichia coli chromosome" Molec Gen Genet 255:449-459 (1997)
• Ford JM, Hanawalt PC "Expression of wild type p53 is required for efficient global nucleotide excision repair in UV-irradiated human fibroblasts" J Biol Chem 272:28073-28080 (1997)
• Tornaletti S, Donahue BA, Reines D, Hanawalt PC "Nucleotide sequence context effect of a cyclobutane pyrimidine dimer upon RNA polymerase II transcription" J Biol Chem. 272:31719-31724 (1997)
• Crowley DJ, Hanawalt PC "Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimer but not 6-4 photoproducts, in UV-irradiated Escherichia coli" J. Bacteriol 180:3345-3352 (1998)
• Hanawalt PC "Genomic instability: Environmental invasion and the enemies within" Mut Res 400:117-125 (1998)
• Hanawalt PC and Spivak G "Transcription-coupled DNA repair: Which lesions? Which diseases? in Advances in DNA damage and Repair, Dizdaroglu and Karakaya (eds.), Plenum Press, New York, pp. 169-179 (1999)
• Courcelle J, Crowley DJ, Hanawalt PC "Recovery of DNA replication in UV-irradiated Escherichia coli requires both excision repair and RecF protein function" J Bact. 181 3:916-922 (1999)
• Tornaletti S, Hanawalt PC "Effect of DNA lesions on transcription elongation" Biochimie 81:139-146 (1999)
• Hwang BJ, Ford JM, Hanawalt PC, Chu G "Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair" Proc. Natl. Acad. Sci. USA 96:424-428 (1999)
• Tornaletti S, Reines D, Hanawalt PC "Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA" J Biol. Chem. 274:24124-24130 (1999)
• Ganesan AK, Hunt J, Hanawalt PC "Expression and nucleotide excision repair of a UV-irradiated reporter gene in unirradiated human cells" Mutat. Res. DNA Repair 433:117-126 (1999)
• Courcelle J, Hanawalt PC "RecQ and RecJ Process Blocked Replication Forks Prior to the Resumption of Replication in UV-Irradiated Escherichia coli" Molecular Gen Genet 262:543-551 (1999)
• Eisen J, Hanawalt PC, "A Phylogenomic study of DNA repair genes, proteins, and processes" Mut Res:DNA Repair 435:171-213 (1999)
• Oh DH, Hanawalt PC, "Triple helix-forming oligonucleotides target psoralen adducts to specific chromosomal sequences in human cells" Nucl Acids Res 27:4734-4742 (1999)
• Nouspikel T, Hanawalt PC, "Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression" Molec Cell Biol 20:1562-1570 (2000)
• Lloyd D, Hanawalt PC "p53-dependent Global Genomic Repair of Benzo[a]pyrene-7,8-diol-9,10 -epoxide adducts in human Cells" Cancer Res 60:517-521 (2000)
• Tang J, Huang BJ, Ford J, Hanawalt PC, Chu G, "Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis" Molec Cell5:737-744 (2000)
• Hanawalt PC "DNA repair:The bases for Cockayne syndrome," News and Views, Nature 405:415-416 (2000)
• Bowman K, Sicard D, Ford J, Hanawalt PC, "Reduced global genomic repair of UV light-induced cyclobutane pyrimidine dimers in Simian virus 40 transformed human cells" Molec. Carcinogenesis 29:17-24 (2000)
• Hanawalt PC, Crowley DJ, Ford JM, Ganesan AK, Lloyd DR, Nouspikel T, Smith CA, Spivak G, and Tornaletti S "Regulation of nucleotide excision repair in bacteria and mammalian cells" In Cold Spring Harbor Symposia on Quantitative Biology, Vol 65: Biological responses to DNA damage p183-191 (2000)
• Hanawalt PC "Controlling the Efficiency of Excision Repair" Mut Res: DNA Repair 485:3-13 (2001)
• Courcelle J, Ganesan A, Hanawalt PC "Therefore, what are recombination proteins there for?" Bioessays 23:463-470 (2001)
• Courcelle J, Khodursky A, Peter B, Brown PO, and Hanawalt PC "Comparative gene expression profiles following UV exposure in wild type and SOS deficient Escherichia coli" Genetics 158:41-64 (2001)
• Courcelle J, Hanawalt PC "Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination" Proc. Natl. Acad. Sci USA 98:8196-8202 (2001)
• Oh D, King BA, Boxer SG, Hanawalt PC "Spatially localized generation of nucleotide sequence-specific DNA damage" Proc. Natl. Acad. Sci USA 98:11271-11276 (2001)
• Hanawalt PC "Revisiting the Rodent Repairadox" Enviro. Molec. Mut. 38:89-96 (2001)
• Tornaletti S, Maeda L, Lloyd DR, Reines D, Hanawalt PC "Effect of thymine glycol on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II" J. Biol Chem 276:45367-45371 (2001)
• Nouspikel T, Hanawalt PC "DNA repair in terminally differentiated cells" DNA Repair 1:59-75 (2002)
• Van Houten B, Eisen JA, Hanawalt PC "A Cut Above: Discovery of an alternative excision repair pathway in bacteria" Commentary in Proc. Natl. Acad. Sci. USA 99:2581-2583 (2002)
• Svetlova M, Solovjeva L, Pleskach N, Yartseva N, Yakovleva T, Tomilin N, Hanawalt PC "Clustered sites of DNA repair synthesis during early nucleotide excision repair in ultraviolet light-irradiated quiescent human fibroblasts" Exptl. Cell Res 276:284-295 (2002)
• Spivak G, Itoh T, Matsunaga T, Nikaido O, Hanawalt P, Yamaizumi M 'Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers" DNA Repair 1:629-643 (2002)
• Lloyd D, Hanawalt PC "p53 controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts" Cancer Res. 62:5288-5294 (2002)
• Hanawalt PC "Subpathways of nucleotide excision repair and their regulation" Oncogene 21:8949-8956 (2002)
• Nouspikel T, and Hanawalt PC "When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease" Bioessays 25:168-173 (2003)
• Kalogeraki V, Tornaletti S, Hanawalt PC "Transcription arrest at a lesion in the transcribed DNA strand in vitro is not affected by a nearby lesion in the opposite strand" J. Biol Chem 278:19558-19564 (2003)
• Cline SD, Hanawalt PC "Who's on first in the cellular response to DNA damage?" Nature Review/Molec. Cell Biol. 4:361-372 (2003)
• Tornaletti S, Patrick SM, Turchi JJ, Hanawalt PC "Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA" J. Biol. Chem. 278:35791-35797 (2003)
• Hanawalt PC, Ford JM, Lloyd DR "Functional characterization of global genomic DNA repair and its implications for cancer" Mutation Research 544:107-114 (2003)
• Courcelle J, Hanawalt PC "RecA-dependent recovery of arrested DNA replication forks" Ann. Review of Genetics 37:611-646 (2003)
• Hanawalt PC "Four decades of DNA repair; from early insights to current perspectives" Biochimie 85:1043-1052 (2003)
• Tornaletti S, Maeda LS, Kolodner RD, Hanawalt PC "Effect of 8-oxoguanine on transcription elongation by T7 RNA polymerase and mammalian RNA polymerase II" DNA Repair 3:483-494 (2004)
• Cline SD, Riggins JN, Tornaletti S, Marnett LJ, Hanawalt PC "Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II" Proc Natl Acad Sci USA 101:7275-7280 (2004)
• Svetlova, S, Solovjeva L, Blasius M, Shevelev I, Hubscher U, Hanawalt P, Tomilin N "Differential incorporation of halogenated deoxyuridines during UV-induced DNA repair synthesis in human cells" DNA Repair (in press) (2005)
• Kalogeraki V, Tornaletti S, Cooper PK, Hanawalt PC "Comparative TFIIS-mediated transcript cleavage by mammalian RNA polymerase II arrested at a lesion in different transcription systems" DNA Repair 4:1075-1087 (2005)
• Xu G, Spivak G, Mitchell DL, Mori T, McCarrey JR, McMahan CA, Walter RB, Hanawalt PC, Walter CA –Nucleotide excision repair activity varies among murine spermatogenic Cell Types” Biology of Reproduction 73:123-130 (2005)
• Spivak G. and Hanawalt P. "Host cell reactivation of plasmids containing oxidative DNA lesions is defective in Cockayne syndrome but normal in UV-sensitive syndrome" DNA Repair 5:13-22 (2006)
• Spivak G, Pfeifer GP, Hanawalt PC "In vivo assays for transcription-coupled repair" (eds. Judith L Campbell & Paul Modrich) Methods in Enzymology: DNA Repair 408:223-246 (2006)
• Wang Y, Sheppard TL, Tornaletti S, Maeda LS, Hanawalt PC. "Transcriptional inhibition by an oxidized abasic site in DNA". Chemical Research in Toxicology 19:234-241 (2006)
• Tornaletti S, Maeda L, Hanawalt PC. "Transcription arrest at an abasic site in the transcribed strand of template DNA" Chemical Research in Toxicology 19:1215-1220 (2006)
• Cline S, Hanawalt PC. "Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae" DNA Repair 5:611-617 (2006)
• Morganroth P, Hanawalt PC. "Role of DNA Replication and Repair in Thymineless Death in Escherichia Coli" J. Bacteriology 188:5286-5288 (2006)
• Hsu P, Hanawalt PC, Nouspikel T. "Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation" Mutation Research 614:3-15 (2007)
• Nouspikel T, Hanawalt PC. "Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme" Proc. Natl. Acad. Sci. USA 103:16188-16193 (2006)
• Nouspikel T, Hyka-Nouspikel N, Hanawalt PC. "Transcription domain-associated repair in human cells" Cell Molec. Biol. 26:8722-8730 (2006)
• Hanawalt PC. Leading Edge Commentary: "Research Collaborations: Trial, Trust, and Truth." Cell 126:823-825 (2006)
• Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehman AR, Lindahl T, Lowndes N, Sarasin A, Wood RD. "DNA repair: from molecular mechanism to human disease" (Noordwijkerhout, April 2006, Meeting Report). DNA Repair 5:986-996 (2006)
• Hanawalt PC. "Maintaining the genome" Review of DNA Repair and Mutagenesis (Second Edition, ASM press) by EC Friedberg, GC Walker, W Siede, RD Wood, RA Schultz, T Ellenberger. Nature Cell Biol. 8:1312 (2006)


Last Updated: March 29, 2007
Copyright 1998, Graciela Spivak
gspivak@stanford.edu