DANIEL S. CHEN

                

EDUCATION         

Stanford University       

Stanford, CA

Medical Oncology Fellowship                                                  7/2000–6/2003

Internal Medicine Residency                                              7/1998-6/2000                                                                                                                         

University of Southern California School of Medicine                                       

Los Angeles, CA

Doctor of Medicine                                                                   9/1990-5/1998

Doctor of Philosophy, Microbiology and Immunology            7/1992-5/1996

Massachusetts Institute of Technology                                                       

Cambridge, MA

Bachelor of Science, Biology                                                    9/1986-5/1990

Brookline High School                                                                       

Brookline, MA

Graduate with honors                                                                May 1986

HONORS AND AWARDS

Oral Presentations

Centers of Cancer Nanotechnology Excellence (U54)                                                                     

Investigator                                                                                2006             

Seed Funding                                                                       

Office of Technology Licensing, Stanford University                2003

Salerni Collegium M.D./Ph.D. Full Scholorship

University of Southern California                                               1990

First Place Award

Massachusetts State Science Fair                                               1986

RESEARCH EXPERIENCE         

Diagnostic Sub-Team Leader                                                   South San Francisco, CA

Genentech, Inc.                                                                          3/2006-present

Associate                                                                                   Stanford, CA

Howard Hughes Medical Institute                                              7/2003-2/2006

Stanford Medical Center                                                                                                               

Post-Doctorate Fellow                                                             Stanford, CA

Medical Oncology                                                                     7/2001-7/2003

Stanford Medical Center                                                                                                               

Post-Doctorate Fellow                                                              Los Angeles, CA

Gene Therapy Laboratories                                                        1/1996-6/1996

University of Southern California School of Medicine                                                                                                 

Ph.D. Candidate                                                                        Los Angeles, CA

Howard Hughes Medical Institute                                              7/1992-1/1996

University of Southern California School of Medicine

Research Assistant                                                                    Cambridge, MA

Massachusetts Institute of Technology                                        1987-1989

WORK EXPERIENCE

Medical Director                                                                       South San Francisco, CA

Genentech, Inc.                                                                           2/2006-present

Adjunct Clinical Faculty/Oncology                                           Stanford, CA        

Stanford Cancer Center/Stanford Medical Center                        7/2003-present

Department of Internal Medicine, Division of Medical Oncology

Multi-disciplinary melanoma clinic

Editor                                                                                         Los Angeles, CA

USC Journal of Medicine                                                            1995-1998

Instructor                                                                                   Cambridge, MA

Physical Education                                                                      1989-1990

Massachusetts Institute of Technology

Instructor                                                                                   Brookline, MA

Advanced Placement Computer Science                                     1985-1986

Brookline High School

MEMBERSHIP

American Society of Clinical Oncology

Society for Melanoma Research              (Founding Member)             

American Medical Association

American Association of Cancer Research                                                

PUBLICATIONS

Chen DS, Davis, MM. Molecular and Functional Analysis Using Viable Cell Microarrays. Curr. Opin. Chem. Biol, 2006, 10(1):28-34.

Chen DS, Soen, Y, Stuge, TB, Lee, PP, Weber, JS, Brown, PO, Davis, MM. Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness After Vaccination Using a Functional Microarray.  PLoS Med, 2005, 2(10):1018-1030.

Chen DS, Davis MM. Cellular immunotherapy: Antigen recognition is just the beginning. Springer Semin. Immuno, 2005, 27(1):119-127.

Huse, M, Lillemeier, BF, Kuhns, MS, Chen, DS, Davis, MM.  T Cells Use Two Directionally Distinct Pathways for Cytokine Secretion.  Nat, Immunol, 2006, 7(3):247-255.

Soen, Y, Chen, DS (co-first author), Kraft, DL, Davis, MM, Brown, PO.  Detection and Characterization of Cellular Immune Responses Using Peptide-MHC Microarrays.  PLoS Biol, 2003, 1(3):429-438.

        

Chen, DS, Zhu, N, Hung, G, Skotzko, MJ, Hinton, D, Tolo, V, Hall, FL, Anderson, WF, Gordon, EM. Retroviral vector-mediated transfer of an antisense cyclin G1 construct inhibits osteosarcoma tumor growth in nude mice. Human Gene Therapy, 1997, 8(14):1667-674.

Chen, DS, Asanaka, M, Chen, FS, Shively, JE, Lai, MM. Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis  virus receptors.  J Virol 1997, 71(2):1688-91.

Kraeft, S, Chen, DS, Chen, LB, Lai, MM. Mouse hepatitis virus infection induces an early, transient calcium influx in mouse astrocytoma cells. Experimental Cell Research, 1997, 237(1):55-62.

        

Chen, DS, Asanaka, M, Yokomori, K, Wang, F, Hwang, SB, Li, HP, Lai, MM. A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Proc Natl Acad Sci USA, 1995, 92(26):12095-9.

NATIONAL ABSTRACTS

Functional and molecular profiling of heterogeneous tumor samples using a novel cellular microarray. AMERICAN SOCIETY OF CLINICAL ONCOLOGY 2004.

A novel cellular microarray identifies functional deficiencies in tumor-specific T cell responses. AMERICAN SOCIETY OF CLINICAL ONCOLOGY 2004.

A novel brain-specific carcinoembryonic antigen glycoprotein family member lacking a transmembrane domain serves as a virus-strain specific receptor for Mouse Hepatitis Virus infection.  AMERICAN SOCIETY OF VIROLOGY, 1994.

Mechanism of virus entry: Mouse Hepatitis Virus infection stimulates calcium influx and is inhibited by calcium channel blockers. AMERICAN SOCIETY OF VIROLOGY, 1994.

A novel brain-specific, pregnancy-specific glycoprotein serves as a Mouse Hepatitis Virus receptor. VIIth International CEA/PSG Meeting, 1995.


Guitarist, rock band “About Face” (1988-1990), “Not Tonight” (1986-1987).  Captain, Intercollegiate Ultimate Frisbee team; Finalist, Washington D.C. National Tournament (1996).  Art piece “Water” displayed at USC art show (1991).  Fluent in Chinese language (Mandarin).  Enjoy Skiing, basketball, football, carpentry, wine collecting and consumption, poetry and fatherhood.