nanoDxRx.jpg

Nanomedicine Portal

 SoM
Demir Akin, DVM, PhD Home |  Research |  Publications |  News |  Links | Intranet
Search Google | Journals | Highlights | Conference Papers |Talks

Publications

  1. Fu, A, Wilson RJ, Smith BR, Mullenix J, Earhart C, Akin D, Guccione S, Wang SX, Gambhir S.S. Fluorescent magnetic nanoparticles for magnetically enhanced cancer imaging and targeting in living subjects. ACS Nano, 6:6862-6869, 2012.
  2. Mirkin, C.A., A. Nel, C. S. Thaxton, B.A. Baird, C. Batt, D. Grainger, S.S.Gambhir, D. Akin, O. Zhou, J.F. Stoddart, T.J. Meade, P. Grodzinski, D. Farrell, H.F. Tibbals, J. De Simone. Nanotechnology Research Directions for Societal Needs in 2020. Nanobiosystems, Medicine and Health. Eds: M.C. Roco, C.A. Mirkin and M.C. Hersham, NSF and Springer Verlag, 2011.
  3. Akin, D., S.S. Gambhir. Theranostics. NCI Cancer Nanotechnology Plan (2010-2020), 2010.
  4. Park, K. H.J. Suk, D. Akin and R. Bashir. Dielectrophoresis-based cell manipulation using electrodes on reusable printed circuit board. Lab on Chip 9:2224-2229, 2009.
  5. Moon, J.M., D. Akin, Y. Xuan , P.DYe ., P. Guo, and R. Bashir. Capture and alignment of phi29 viral particles in sub-40 nanometer porous alumina membranes.  Biomedical Microdevices 11:135-42, 2009.
  6. Bhattacharya, S., S. Salamat, D. Morisette, P. Banada,D. Akin, Y.S. Liu, A.K. Bhunia, M. Ladisch and R. Bashir. PCR-based detection in a micro-fabricated platform. Lab on Chip 8:1130:1136, 2008.
  7. Lee, J., J. Jang,D. Akin, C.A. Savran, and R. Bashir. Real-time detection of air-borne viruses on a mass-sensitive device. Applied Physics Letters. 2008. (In Press).
  8. Akin, D., J. Sturgis, K. Ragheb, D. Sherman, K. Burkholder, J. P. Robinson,  A. K. Bhunia, S. Mohammed and R. Bashir.  Bacteria-mediated delivery of nanoparticles and cargo into cancer cells. Nature Nanotechnology, 2:441-449, 2007.
  9. Iqbal, S.,D. Akin and R. Bashir. Solid State Nanopores with DNA Selectivity. Nature Nanotechnology, 2:243-248, 2007.
  10. Choi, M.R., Stanton-Maxey, K.J., Stanley, J.K., Levin, C.S., Bardhan, R.,D. Akin, Badve, S., Sturgis, J., Robinson, J.P., Bashir, R., Halas, N.J., Clare, S.E.  A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors. Nano Letters, 7:3759-3765, 2007.
  11. Bajaj, P.,D. Akin, A. Gupta, O. Auciello and R.Bashir.  Ultrananocrystalline diamond film as an optimal cell interface for biomedical applications. Biomedical Microdevices, I9:787-94, 2007.
  12. Park, K.,D. Akinand R. Bashir. Electrical capture and lysis of vaccinia virus particles using silicon nano-scale probe array. Biomedical Microdevices, Biomed Microdevices, 9:877-83, 2007.
  13.  Jang, J.,D. Akin, K.S. Lim, S. Broyles, M.R. Ladisch and R. Bashir. Capture of airborne nanoparticles in swirling flows using non-uniform electrostatic fields for bio-sensor applications. Sensors and Actuators B, 121:560-566, 2007.
  14. Bhattacharya, S., J. Jang, L. Yang,D. Akin, and R. Bashir. Biomems and Nanotechnology based approaches for rapid detection of biological entities. J. Rapid Methods & Automation in Microbiology, 15:1-32, 2007.
  15. Akin, D.  Book Review:Nanotechnology in Biology and Medicine: Methods, Devices, and Applications. Edited by Tuan Vo-Dinh. ChemMedChem2(10):1534-1535, 2007.
  16. Gupta, A., P.R. Nair,D. Akin, M, Ladisch, S. Broyles, M. A. Alam and R. Bashir.  Anomalous resonance in a nanomechanical bioSensor. Proc. Natl. Acad. Sci., USA, 103:13362-13367, 2006.
  17. Johnson, L., A. Gupta,D. Akin, A. Ghafoor, R. Bashir. Characterization of vaccinia virus particles using microscale silicon cantilever resonators and atomic force microscopy.  Sensors and Actuators B, 115:189-197, 2006.
  18. Ghafoor, A*.,D. Akin*, R. Bashir. Delocalization of vaccinia virus components observed by Atomic Force and Fluorescence Microscopy. NanoBiotechnology, 4:337-346, 2005.
  19. Li, H., Y. Zheng,D. Akin, and R. Bashir.  Characterization and modeling of a microfluidic dielectrophoresis filter for biological species. J. Microelectromechanical Systems143:103-112, 2005.
  20.  Akin, D., H. Li and R. Bashir.  Real-time virus trapping and fluorescent imaging in micro-fluidic devices. Nano Letters4:257-259, 2004.
  21. Gupta, A.,D. Akinand R. Bashir.  Detection of bacterial cells and antibodies using surface micromachined thin silicon cantilever resonators. J. Vacuum Sci. & Tech. B:Microelectronics and Nanometer Structures.22:2785-2791, 2004.
  22.  Gupta, A.,D. Akin, and R. Bashir.  Single virus particle mass detection using microresonators with nanoscale thickness. Applied Physics Letters.84, 1976-1978, 2004.
  23. Chang, W.J.,D. Akin, R. Bashir.  Poly(dimethylsiloxane) (PDMS) and silicon hybrid biochip for bacterial culture. Biomedical Microdevices, 5:281-290, 2003.
  24.  Elibol, O.H., D. Morisette,D. Akin, J. P. Denton, and R. Bashir.  Integrated nanoscale silicon sensors using top-down fabrication. Applied Physics Letters 83, 4613, 2003.
  25.  Gupta, A.,D. Akin, and R. Bashir.  Resonant mass biosensor for ultrasensitive detection of bacterial cells.  Microfluidics, BioMEMS, and Medical Microsystems, Holger Becker, Peter Woias, Editors, In: Proc. SPIE Int. Soc. Opt. Eng.4982, January 2003, pp. 21-27.
  26. Huang, T., W.J. Chang,D. Akin, R. Gomez, R. Bashir, N. Mosier and M.R. Ladisch.  Microfiber assisted fabrication of microfluidic channles using Poly(dimethylsiloxane).    American Institute for Chemical Engineers (AIChE) Journal, 49:2984-2987, 2003.
  27.  Huang, T., T. Geng,D. Akin, W.J. Chang, J. Sturgis, R. Bashir, A.K. Bhunia, J.P. Robinson, and M.R. Ladisch.  Microassembly of functionalized particulate monolayer on C18 derivitized SiO2surfaces. Biotechnology and Bioengineering83:416-427, 2003.
  28.  Bashir, R. andD. Akin.  From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms. Proc. Mat. Res. Soc.773:911.-914, 2003.
  29.  Akin, D., C.C. Wu, and T.L. Lin.  Analysis of sequence of nucleocapsid gene reveals genetic recombination between infectious bronchitis virus and turkey coronavirus. Acta Virologica, 45:31-38, 2001.
  30.  Akin, D., C.C. Wu, and T.L. Lin.  A ribozyme targeted to RNA polymerase gene of infectious bursal disease virus effectively cleaves and inhibits expression of the viral gene product. Acta Virologica, 43:341-347, 1999.
  31.  Akin, D., C.C. Wu, and T.L. Lin.  Amplification and cloning of complete infectious bursal disease virus genomic  RNA segments by a long and accurate PCR. J. Virological Methods, 82:55-61, 1999. 
  32.  Akin, D., Wu, C.C. and Lin, T.L.  A comparison of two RNA isolation methods for double-stranded RNA of infectious bursal disease virus. J. Virological Methods, 74:179-84, 1998. 
  33.  Wu, C.C., Lin, T.L. andAkin, D.  Quantitative competitive polymerase chain reaction for detection and quantification of infectious bursal disease virus cDNA and RNA. J. Virological Methods, 66:29-33, 1997. 
  34.  Akin, D., C.C. Wu, T.L. Lin and R.W.  Keirs.  Chemiluminescent detection of infectious bursal disease virus with a PCR-generated digoxigenin-labeled probe. J. Veterinary Diagnostic Investigations 5:166-173, 1993. 

Papers Highlighted as Frontier Research

  1. Nature. Tiny scales weigh virus, February 11, 2004.  Single virus particle mass detection using microresonators with nanoscale thickness, published in Applied Physics Letters 84, 1976 (2004). http://www.nature.com
  2. Virtual Journal of Biological Physics Research,  December 1, 2004.  Detection of bacterial cells and antibodies using surface micromachined thin silicon cantilever resonators, published in Journal of Vacuum Science & Technology B 22, 2785 (2004). http://www.vjbio.org.
  3. Virtual Journal of Nanoscale Science & Technology, March 22, 2004.  Single virus particle mass detection using microresonators with nanoscale thickness, published in Applied Physics Letters 84, 1976 (2004). http://www.vjnano.org.
  4. Virtual Journal of Biological Physics Research, December 1, 2003. Integrated nanoscale silicon sensors using top-down fabrication, published in Applied Physics Letters 83, 4613 (2003). http://www.vjbio.org.
  5. Leading Edge Research Supported By National Institutes of Biomedial Imaging and Biological Engineering(NIBIB).

Invited Papers and Selected Conference Papers

  1. Iqbal, S.M., B.M. Venkatesan, D. Akin, R. Bashir. Biochemistry in the Nanopores. American Physical Society, 2008 APS March Meeting, UCLA, March 10-14, 2008.
  2. Bashir, R. D. Akin and L. Yang. BioMEMS and Bionanotechnology: Interfacing Life Sciences and Engineering at the Micro and Nanoscale 210th Electrochemical Society Meeting, October 29, 2006, Cancun, Mexico.
  3. Davila, A., A. Gupta, D. Akin, T. Walter, A. Aronson and R. Bashir. Spore detection in air and fluid using microcantilever sensors. Proceedings of the  Materials Research Society, Fall 2005, Boston, MA.
  4. Li, H., L. Yang, D. Akin, T. Geng, A. Bhunia, T. T. Huang, M. Ladisch, R. Bashir Dielectrophoresis and antibody-mediated selective capture of microorganisms in micro-fluidic biochips.  Transducers-2005, Seoul, Korea ,  June 5-9, 2005.
  5.  Gupta, A.D. Akinand R. Bashir.  Airborne virus particle detection using nanomechanical resonators with integrated dielectrophoresis concentration electrodes.  Hilton Head, 2004.
  6.  Gupta, A.,D. Akin and R. Bashir.  Mechanical effects of attaching protein layers on nanoscale-thick cantilever beams for resonant detection of virus particles.  IEEE-MEMS 2005.
  7.  R. Bashir, D. Akin, R. Gómez, H. Li, W-J.Chang, A. Gupta.  From BioMEMS to Bionanotechnology: Integrated BioChips for the Detection of Cells and Microorganisms. Proceedings of the MRS Spring Meeting, San Francisco, CA. April 22, 2003.
  8.  Elibol, O. H., D. Morisette,D. Akin, and R. Bashir.  Integrated nanoelectronic sensor.  CHI, BioMEMS, 2003.
  9.  R. Bashir, R. Gomez, H. Li, D. Akin, A. Gupta, Interfacing Micro/NanoTechnology with Life-Sciences for Detection of Cells and Microorganisms, Bipolar / BiCMOS Circuits and Technology Meeting, September 28-30, 2003, Toulouse, France.
  10.  Gupta, A., D. Akin and R. Bashir.  Thin single-crystal silicon cantilever beam based gravimetric biosensor for detection of bacterial cells.  Eighth Annual Micromachining & Microfabrication Symposium, San Jose, CA, January 25-31, 2003.
  11.  Gomez,R., T. Geng, T. Huang, D. Akin, A. Bhunia, M. Ladisch and R. Bashir.  Microfluidic BioChips for the electronic detection of microorganisms. Eighth Annual Micromachining & Microfabrication Symposium, San Jose, CA, January 25-31, 2003.
  12.  Gupta, A., D. Akin, R. Bashir.  Resonant Mass Biosensor For Ultrasensitive Detection Of Bacterial Cells.  Microfluidics, BioMEMS, And Medical Microsystems Conference At Spie's Photonics West Micromachining And Microfabrication 2003 Symposium, San Jose, CA Jan. 27th 2003.
  13.  Huang, T. T., T. Geng, D. Akin, W. Chang, J. Sturgis, R. Bashir, A. K. Bhunia, J. P. Robinson, and M. R. Ladisch, Biomediated Assembly of Functionalized Microbeads for Capture of Microorganisms, BIOT Division Paper 97, 225th ACS National Meeting, Section: Novel Bioanalyses Using Lab-on-a-Chip Technologies, New Orleans, March 24, 2003.
  14.  McNally, H. A., H. Kufluoglu, D. Akin, J. Grimmer, J. Walker, R. Shi, R. Borgens, and R. Bashir A chemical sensor using neurons and a 3-d micro-fluidic chip.  The Materials Research Society (MRS) 2002 Meeting Boston, MA, December 2-6, 2002.
  15.  Lin, T., C. Wu, C. Loa, D. Akin, H. Thacker, T. Bryan and T. Hooper.  Gene 5 in turkey coronavirus closely related to that of avian infectious bronchitis virus. American Veterinary Medical Association, Symposium on Poultry Vaccines and Vaccination Practices.   July 13-17, 2002,  Nashville, TN.
  16.  The electric power system as a customer-driven system endowed with self-healing capabilities. L.H. Tsoukalas, R. Gao, X. Wang, D. Akin, and S.Viswanathan,.  Institute for Research and Education in Power System Dynamics (IREP), Onomichi City, Japan , 2001.
  17.  Lin, T., D. Akin and C. Wu.  Amplification of turkey coronavirus genes by polymerase chain reaction.  American Association for Veterinary Laboratory Diagnosticians, San Diego, CA, October 7-14, 1999.

Selected Presentations and Abstracts 

  1.  Samir M. Iqbal, S.M., E.P. Judokusumo, B. M. K. Venkatesan, D. Akin and R. Bashir. Biochemical Functionalization of Semiconductor Devices: Cation Selectivity and Surface Charges. Electronic Materials Conference, June 22-24, 2007, Bloomington IN.
  2. Park, K., J.Jang, D. Akin, D. Irimia, M. Toner, and R. Bashir. Capture, growth and mass measurement of mammalian cells on silicon cantilever arrays. Biomedical Engineering Society, September 22, 2007, Los Angeles, LA.
  3.  Liu, Y., P.P. Banada, S. Bhattacharya, D. Akin, A. Bhunia, and R. Bashir.  Electrical Characterization of DNA Molecules in Fluids using Impedance Measurements. Biomedical Engineering Society, September 22, 2007, Los Angeles,LA.
  4. Battacharya,S. S. Salamat, R. Bashir, Y. Liu, P. Banada, A. Bhunia, and D. Akin. Integrated detection of microorganisms in a microfluidic biochip. Biomedical Engineering Society, September 22, 2007, Los Angeles, LA.
  5.  D. Akin and R. Bashir. Biologically-Inspired Engineering and MEMS for Realization of  Nanomedicine. Nanoalliance Conference, 2006, Columbia, MO.
  6.  Davilla, A., T. Walter, A. Aronson, D. Akin, and R. Bashir.  Detection ofBacillus anthracisspores using microcantilevers.  Bacterial Spores: challenges and future directions for biodefense.  November 14 - 16, 2004, Argonne National Laboratory, Argonne, IL.
  7. Li, H., D. Akin, R. Bashir.  Applications of Dielectrophoretic "Tweezers" in Determining the Biological Receptor-Ligand Interaction Forces and Selectively Removing Different Species in Biochips", 46th Electronic Materials Conference,  June 23-25, 2004, Notre Dame University, Notre Dame, IN.
  8. Chang, W.J., R. Gómez, H. Li, D. Akin, and R. Bashir.  An investigation of fluid absorption in hybrid poly(dimethylsiloxane) (PDMS)/silicon biochips for long-term cell-incubation applications. 226thACS National Meeting, September 7-11, 2003, NewYork, NY.
  9. Gupta, A., D. Akin and  R. Bashir.  A micro-electro-mechanical gravimetric biosensor for bacterial detection.  BioMEMS and Biomedical Nanotechnology 2002 Conference, Columbus, OH.
  10.  McNally, H., H. Kufluoglu, D. Akin, and R.Bashir Interfacing neurons with electrodes.  . 2002 BioMEMS Conference, Columbus , OH.
  11. Gupta, A., D. Akin and  R. Bashir.  Detection of Bacterial cells using mechanical resonant frequency gravimetric biosensor based on a surface micro-machined thin silicon cantilever beam.  Materials Research Society, December 2-6, 2002 Boston, MA.
  12.  Akin, D., T. Lin, and C.C. Wu.  Inhibition of the expression of dsRNA-dependent-RNA polymerase gene product from infectious bursal disease virus by a ribozyme, 1998.  North Central Emerging Diseases Conference,  Indianapolis, IN. 
  13.  Akin, D., C. Wu, and T.L. Lin.  A ribozyme effectively cleaves and inhibits the synthesis of viral RNA polymerase of infectious bursal disease virus nucleic acids, 1996.  Regional Phi-Zeta Poster Session, West Lafayette, IN. 
  14. Akin, D., C.C. Wu, and T.L. Lin.  A comparison of two RNA isolation methods for purification of infectious bursal disease virus double-stranded RNA, 1996.  Regional Phi-Zeta Poster Session, W. Lafayette, IN. 
  15.  Akin, D., C. Wu, and T. Lin.  Quantitative-competitive PCR for the detection and quantification of infectious bursal disease virus nucleic acids, 1995.  Regional Phi-Zeta Poster Session, W. Lafayette, IN. 
  16.  Akin, D.  Antiviral approach to infectious bursal disease virus, 1993.  Dept. Comparative Pathiobiology, Purdue University.