COVTDT - Description

This program, developed by J Halpern and AS Whittemore, extends the TDT (Transmission Disequilibrium Test) to provide a strategy for dealing with potential confounding of genetic association test by established risk factors when analyzing data from parents and offspring.

COVTDT - Background References

A detailed description of the statistical underpinnings of the software can be found in the following articles:

Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet Full Text

Rabinowitz D, Laird N. 2000. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered. Jul-Aug;50(4):211-23. Full Text

Shih M-C, Whittemore AS. Tests for genetic association using family data. Genet Epidemiol 22: 128-145, 2002. Full Text

Whittemore AS, Halpern J. 2003. Genetic association tests for family data with missing parental genotypes: A comparison. Genet Epidemiol. Jul;25(1):80-91. Full Text

Whittemore AS, Halpern J, and Ahsan H. 2005. Covariate Adjustment in Family-based Association Studies. Genet Epidemiol. 2005 Apr;28(3):244-55. Full Text

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