Introduction

  Update 2000

  Virus Profiles
    NLV
    Norwalk
    SLV
    Sapporo

  Pathogen Cards
    St. Louis Encephalitis
    HPV2
    Had5
    Kuru
    HTLV-1
    Guanarito

  Drug Profile
    Amantidine
    AZdU (CS-87)

  References

  Web Links


  Elizabeth Salas &
  Melissa Valadez
  Humans and Viruses
  Human Biology 115A
  Winter, 2000
  Robert Siegel,
  Instructor

  Date completed: 3/6/00
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St. Louis Encephalitis

St. Louis Encephalitis
(SLE)Louis Flavi,

the Mosquito from St. Louis,
brings Encephalitis
Description of virus (taxonomy): Family - Flaviviridae, Genera - Papilloma
Icosahedral, (+) ssRNA, monopartite, enveloped, 40-50nm,
Power (virulence)
      Most devastating encephalitis disease in the United States
Offenses
      Attacks (Mode of replication, transmission)
Natural reservoir in birds. Transmission through Culex mosquitoes that feed mainly on birds
      Transmitted primarily arthropod borne (mosquito bites)
      Enter cell through receptor-mediated endocytosis, ph dependent fusion Replication takes place in cytoplasma
Fully formed viruses appear within endoplasmic reticulum and released through cell lysis
Outcome (Syndrome, Symptoms)
Symptoms are usually mild and include fever, headache, tiredness, and dizziness In the most severe cases, encephalitis results leading to death
Speed (Incubation Period, Replication Speed)
Long latent period, 12 hours or more
Defenses
Vaccines
Currently there are no prospects of vaccine
Behavioral (Prevention)
Flaviviruses are generally not stable in the environment and can be inactivated by heat,
and by disinfectants containing detergents or lipid solvents.
Found primarily in Americas, greater awareness of disease in Americas
Since transmitted through mosquitoes, protective clothing can stop transmission. When outside, wear long pants and long-sleeved shirts. Individual living in environment conducive for mosquitoes can lead to increased transmission. Stay indoors between dusk and dark. This is when the mosquitoes are most active in their search for food.
Mosquitoes breed in stagnant, polluted waters prevent the development of mosquito breeding grounds Spray exposed skin with insect repellent.
Treatment
      There is no specific treatment for St. Louis encephalitis       Care of patients centers on treatment of symptoms and complications       Prevention is the key
Game action
Neighbor to the right falls ill with St. Louis Encephalitis and loses a turn. You must now inform all players of how virus is transmitted and preventative methods against St. Louis Encephalitis.
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