The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
05-08-13 Liz publishes on eLife!
04-18-13 Joe wins fellowship!
Congratulations to Joe for winning a prestigious 3-year Jane Coffin Childs fellowship! (www.jccfund.org)
04-06-13 Congratulations Kurt
Congrats to Kurt for a beautifully written commentary in Nat Biotech on Beth Levine's autophagy paper.
02-08-13 Congratulations to Liz on her NRSA!
Congratulation to Liz Kirby, PhD, postdoctoral fellow, on being awarded the NIH's highly competitive and prestigious NRSA award.
TWCLab gets the Colbert bump!
TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.