The TWC- Lab is located at the Hospital of Veterans Affairs in Palo Alto. Click here to get directions.
10-10-13 Tony receives a Transformative R01!
Congratulations to Tony for being a 2013 Transformative R01 Award Recipient! You can read more about it here.
09-04-13 Kurt publishes in Neuron!
06-10-13 Jinte wins award!
Congratulations to Jinte for winning a (well-paid) Alzheimer's Association Award for Young Scientists. There was a strong competition this year so this is really awesome.
06-05-13 Kira's thesis defense!
Congratulations to Dr. Kira Mosher for reaching this milestone in her bright career!
05-22-13 Trish receives fellowship!
Congratulations Trisha for receiving a prestigious and highly selective DARE Doctoral Fellowship from Stanford. Well-deserved!
TGF-β signaling in the CNS and role in CNS disease - We discovered that abnormal TGF-β signaling may contribute to Alzheimer’s disease using a number of engineered mouse models that allow us to regulate TGF-β signaling in different cell types. Other studies showed that TGF-β1 can promote accumulation of immune cells in models of autoimmune disease but it can also support the late stages of adult neurogenesis and increase survival of neurons. Engineered mouse models which lack TGF-β receptors in neurons or report activation of signaling by producing indicator proteins are currently being used to study the role of TGF-β signaling in normal CNS function and disease. To try to exploit the beneficial effects of TGF-β signaling in neurons we are developing small molecule activators of this pathway.