| Title | Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Kapoor, R, Wadman MW, Dohm MT, Czyzewski AM, Spormann AM, Barron AE |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 55 |
| Issue | 6 |
| Pagination | 3054-7 |
| Date Published | 2011 Jun |
| ISSN | 1098-6596 |
| Abstract | The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients. |
| Alternate Journal | Antimicrob. Agents Chemother. |
