Research  

The Jeffrey Lab concentrates on breast cancer research. Although still a fairly young lab, we are part of the collaborative group that pioneered human solid tumor genomics using cDNA microarrays, developed by Pat Brown and colleagues here at Stanford. In a close collaboration with Pat Brown in Biochemistry, David Botstein in Genetics, and Anne-Lise Børresen-Dale, Chief of Genetics at the Cancer Research Institute, Norwegian Radium Hospital, University of Oslo, Norway, we are involved in a major effort to define molecular subtypes of breast cancer. We use T7-based RNA amplification techniques and genome-wide expression profiling of tumors with 42,000 clone cDNA microarrays. Molecular tumor profiles are correlated with clinical and pathological data in the expectation that results will impact patient care within the next decade.

For an animation of DNA microarray methodology created by A. Malcolm Campbell PhD from Davidson College, NC: CLICK HERE

In addition to molecular subtyping of breast cancer, our lab is particularly interested in three areas:
1. Molecular profiling of invasive lobular carcinoma
2. Tumor microenvironment (epithelial-stromal interactions in breast cancer)
3. Ethnic variations in breast cancer

We are also studying the effects of cell culture on gene expression profiles of primary breast cancers with Dr. Shanaz Dairkee, Geraldine Brush Cancer Research Institute at CPMC in San Francisco.

                                Lab Group-2007                                       Lab Group-2008

Circulating Tumor Cell(CTC) Genome Profiling
Ashley A. Powell, PhD Research Associate and Amir Ali Haj Hossein Talasaz, PhD Engineering Research Associate
R. Fabian W. Pease, PhD Professor of Electrical EngineeringStanford University	Ron Davis, PhD Professor of Biochemisty Director, Genome Technology Center Stanford University	Michael Mindrinos, PhD Senior Research Scientist Genome Technology Center Stanford University
Stephen Quake, D.Phil. Professor and Bioengineering Investigator Howard Hughes Medical Institute Stanford University	Marc Coram PhD Assistant Professor of Health Research and Policy Biostatistics Stanford University	Richard Bruce, PhD Senior Scientist and Director Institute for Advanced Biomedical Sciences Palo Alto Research Center (PARC)
Bio Marker Research
Robert Mah, PhD Director,Smart Systems Research Laboratory NASA Ames Reaserch Center	Benjamine F. Cravatt III, PhD   Professor and Chair Dept. of Chemical Physiology The Skaggs Institute for Chemical Biology Scripps Research Institute	Shanaz Dairkee, PhD Senior Scientist California Pacific Medical Center Research Institude
Sentinel Lymph Node Research
Richard Olshen, PhD Professor of Health Research & Policy (Biostatistics) and Electrical Engineering and Statistics Stanford University	Holbrook Kohrt, MD  Hemotology Fellow Graduate Student, Cancer Biology Stanford University	Horst Bürger, MD, PhD and Eberhard Korsching,PhD University of Munster Germany

Cancer Genomics Research

Lab Group-2004


Vince Funari, Maureen Chang, Susan Overholser, Stefanie Jeffrey, Youngran Ji, Anita Langerød, Michelle Ferrari

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