N Jahchan, JT Dudley, PK Mazur, N Flores, D Yang, A Palmerton, AF Zmoos, D Vaka, KQT Tran, M Zhou, K Krasinska, JW Riess, JW Neal, KS Park, P Khatri, AJ Butte*, J Sage*. A drug repositioning approach identifies tricyclic antidepressants as potent inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discovery, 2013. *, co-corresponding authors.
P. Garfin, D Min, J Bryson, T Serwold, B Eddris, C Blackburn, E Richie, K Weinberg, N Manley, J Sage*, P Viatour. Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression. J Exp Med, 2013. *, corresponding author.
K Jameson, P Mazur, A Zehnder, J Zhang, B Zanegar, J Sage, P Khavari. IQGAP1 scaffold-kinase interaction blockade selectively targets Ras-MAP kinase-driven tumors. Nature Medicine, 2013.
J Conklin, J. Baker, J Sage. The RB family is required for the self-renewal and survival of human embryonic stem cells. Nature Communications, 2012.
J Sage. The retinoblastoma tumor suppressor gene in stem cell biology. Genes Dev, 2012.
H Chen, X Gu, Y Liu, J Wang, SE Wirt, R Bottino, H Schorle, J Sage, SK Kim. PDGF signaling controls age-dependent proliferation in pancreatic beta-cells. Nature, 2011.
KS Park, LG Martelotto, M Peifer, ML Sos, AN Karnezis, MR Mahjoub, K Bernard, JF Conklin, A Szczepny, J Yuan, R Guo, B Ospina, J falzon, S Bennett, TJ Brown, A Markovic, WL Devereux, CA Ocasio, JK Chen, T Stearns, RK Thomas, M Dorsch, S Buonamici, DN Watkins, CD Peacock*, J Sage*. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nature Medicine, 2011. *, co-corresponding authors.
A Taguchi, K Politi, SJ Pitteri, WW Lockwood, VM Faça, K Kelly-Spratt, CH Wong, Q Zhang, A Chin, KS Park, G Goodman, AF Gazdar, J Sage, DM Dinulescu, R Kucherlapati, RA DePinho, CJ Kemp, HE Varmus, SM Hanash. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell, 2011.
P Viatour, U Ehmer, LA Saddic, C Dorrell, JB Andersen, C Lin, AF Zmoos, BE Schaffer, A Ostermeier, H Vogel, KG Sylvester, SS Thorgeirsson, M Grompe, J Sage. Notch signaling inhibits hepatocellular carcinoma upon inactivation of the RB pathway. J Exp Med, 2011.
M Sirota, JT Dudley, J Kim, AP Chiang, AA Morgan, EA Sweet-Cordero, J Sage, AJ Butte. Discovery and pre-clinical validation of drug indications using compendia of public gene expression data. Science Translational Medicine 2011.
LA Saddic, LE West, A Aslanian, JR Yates III, SM Rubin, O Gozani, J Sage. Methylation of the retinoblastoma tumor suppressor by SMYD2. Journal of Biological Chemistry. 2010.
S Wirt , AS Adler, V Gebala, JM Weimann, BE Schaffer, LA Saddic, P Viatour, H Vogel , HY Chang, A Meissner, J Sage. Cell cycle exit and terminal differentiation independent of the RB gene family during embryonic development. Journal of Cell Biology. 2010.
KV Pajcini, SY Corbel, J Sage, JH Pomerantz, HM Blau. Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell. 2010.
DL Burkhart, SE Wirt, A Zmoos, J Sage. Tandem E2F binding sites in the promoter of the p107 cell cycle regulator control p107 expression and its cellular functions. PLoS Genetics. 2010.
P Viatour, TC Somervaille, S Venkatasubrahmanyam, S Kogan, ME McLaughlin, IL Weissman, AJ Butte, E Passegue, J Sage. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008.