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photo of Alesha B. Castillo Alesha B. Castillo, PhD
Postdoctoral Research Fellow

650/493-5000 ext 6-6252
650/493-4919 fax

Education and Training

California Polytechnic State University, SLO, CA BS Materials Engineering 1997
University of California, Davis, CA MS Biomedical Engineering 2000
University of California, Davis, CA PhD Biomedical Engineering 2004
Indiana University, Indianapolis, IN Musculoskeletal Training Fellow Skeletal Biology/Biomechanics/ Mechanotransduction 2004 - 2006

Research Interests

  • Cell and tissue machanotransduction / skeletal adaptation and regeneration

Professional Societies

Recent Publications

2006 Warden SJ, Fuchs RK, Castillo AB, Nelson IR and Turner CH. Exercise when young provides lifelong benefits to bone structure and strength. Journal of Bone and Mineral Research. Published online November 27, 2006:10.1359.
2006 Warden SJ, Saxon L, Castillo AB, Turner CH. Knee ligament mechanical properties are not influenced by estrogen or its receptors. Am J Physiol Endocrinol Metab 290:E1034-E1040.
2006 Hazelwood SJ, Castillo AB. Simulated effects of marathon training on bone density, remodeling, and microdamage accumulation of the femur. International Journal of Fatigue (in press).
2006 Robling AR, Castillo AB, Turner CH Biomechanical and Molecular Regulation of Bone Remodeling. Annual Reviews of Biomedical Engineering 8:6.1-6.44.
2006 Castillo AB, Levenda JP, Pavlik M, Warden SJ, Li J, Turner CH The effects of low amplitude, broad frequency vibration on cortical bone adaptation in adult female mice. Bone 39(5):1087-96.
2005 Warden SJ, Fuchs RK, Castillo AB, Turner CH Does exercise during growth influence osteoporotic fracture later in life? Journal of Musculoskeletal and Neuronal Interactions 5(4):344-346.
2004 Van Rompay KK, Brignolo LL, Meyer DJ, Jerome C, Tarara R, Spinner A, Hamilton M, Hirst LL, Bennett DR, Canfield DR, Dearman TG, Von Morgenland W, Allen PC, Valverde C, Castillo AB, Martin RB, Samii VF, Bendele R, Desjardins J, Marthas ML, Pedersen NC, Bischofberger N. Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy) propyl]adenine (tenofovir) to newborn and infant rhesus macaques. Antimicrob Agents Chemother 48(5):1469-87.
2002 Castillo AB, Tarantal AF, Watnik MR, Martin RB. Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta). J Ortho Res 20:1185-89.
2002 Tarantal AF, Castillo AB, Ekert JE, Bischofberger N, Martin RB. Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys. J Acquir Immune Defic Syndr 29:207-20.

Invited Presentations

2007 The role of estrogen receptor beta in bone mechanotransduction. 54th Annual Meeting of the American College of Sports Medicine. May 30 - June 2, New Orleans, LA.
2006 The role of estrogen receptor beta in bone mechanotransduction. 28th Annual Meeting of the American Society of Bone and Mineral Research. September 15-19, Philadelphia, PA.
2003 The role of fatigue damage in postmenopausal bone fragility. Indiana Bone & Mineral Club. March 20, Indianapolis, IN.
2002 9-[2-(R)-phosphonomethoxy)propyl]adenine (PMPA) treatment at 30 mg/kg/day can inhibit cortical bone mineralization in rhesus monkeys (Macaca mulatta). 48th Annual Meeting of the Orthopaedic Research Society. February 10-13, Dallas, TX.

Abstracts

2006 Castillo AB, Triplett JW, Pavalko FM, Turner CH. The role of estrogen receptor beta in bone mechanotransduction. Abstracts of the 28th Annual Meeting of the American Society of Bone and Mineral Research, Vol. 21, Suppl 1;S371. September 15-19, Philadelphia, PA. Podium presentation.
2006 Castillo AB, Levenda JP, Pavlik M, Warden SJ, Turner CH. The effects of low amplitude, broad frequency vibration on cortical bone adaptation in adult female mice. Transactions of the 52nd Annual Meeting of the Orthopaedic Research Society, Vol. 31. March 19-22, Chicago, IL.
2006 McGee ME, Castillo AB, Nelson OL, Robbins CT, Donahue SW. The effects of disuse (hibernation) on trabecular bone architecture and mineral density in grizzly bear (Ursus Arctos Horribilis) femurs. Transactions of the 52nd Annual Meeting of the Orthopaedic Research Society, Vol 31. March 19-22, Chicago, IL.
2005 Warden SJ, Fuchs RK, Castillo AB, Turner CH. Mechanical loading during growth has long-term benefits to skeletal health. Abstracts of the 27th Annual Meeting of the American Society for Bone and Mineral Research, Vol. 20, Suppl 1. September 23-27. Nashville, TN.
2005 Hazelwood SJ, Castillo AB. Simulated effects of marathon training on bone remodeling and microdamage accumulation. First International Conference on Mechanics of Biomaterials & Tissues. December 11-15, Waikoloa Beach, HA.
2003 Castillo AB, Metz LN, Martin RB. Ovariectomy results in an increase in intracortical remodeling in the female ferret (Mustela furo). Transactions of the 49th Annual Meeting of the Orthopaedic Research Society, Vol. 28. February 2-5, New Orleans, LA.
2002 9-[2-(R)-phosphonomethoxy)propyl]adenine (PMPA) treatment at 30 mg/kg/day can inhibit cortical bone mineralization in rhesus monkeys (Macaca mulatta). Transactions of the 48th Annual Meeting of the Orthopaedic Research Society, Vol. 27. February 10-13, Dallas, TX. Podium presentation.
2001 Castillo AB, Martin RB. The role of fatigue damage in postmenopausal bone fragility. 31st International Sun Valley Hard Tissue Workshop. August 6-10, Sun Valley, ID.
2000 Hazelwood S. Castillo AB. On the significance of BMU activation frequency and inhibited refilling on trabecular surfaces in predicting femoral porosity using a bone remodeling simulation. Transactions of the 45th Annual Meeting of the Orthopaedic Research Society, Vol. 25. March 12-15, Orlando, FL.

Awards

  • 2006 - Federation of American Societies for Experimental Biology-MARC Program Poster/Oral Presentation Travel Award, 28th Annual American Society of Bone and Mineral Research (ASBMR) Meeting
  • 2006 - Alice L. Jee Memorial Young Investigator Award, Sun Valley Hard Tissue Workshop
  • 2005 - 7th International Bone Fluid Flow Workshop Travel Award
  • 2004 - NIRA Institutional Training Grant Fellow, Anatomy & Cell Biology, Indiana University
  • 2003 - Alice L. Jee Memorial Young Investigator Award, Sun Valley Hard Tissue Workshop
  • 2001 - Alice L. Jee Memorial Young Investigator Award, Sun Valley Hard Tissue Workshop
  • 2001 - National Osteoporosis Foundation Mazess Fellowship Award
  • 2000 - Alice L. Jee Memorial Young Investigator Award, Sun Valley Hard Tissue Workshop
  • 1997 - Graduate Engineering Minority Program/National Institutes of Health Fellow

Last updated 01/16/2007