Final Paper Information

Week 1 - Ricardo Dolmetsch, Stanford University
Wednesday Sept 28	Techniques in neurobiology and calcium signaling Reading: Excitation-Transcription Coupling: Signaling by Ion Channels to the Nucleus Sci STKE. 2003 Jan 21;2003(166):PE4.[full text]
Friday Sept 30	Paper Cleavage of L-type calcium channels generates a novel transcription factor (in press at Nature) [full text]
Monday Oct 3	Seminar: "Converting experience into biochemistry: calcium channel signaling in neurons"

Week 2 - Scott Poethig, University of Pennsylvania
Wednesday Oct 5	micro RNA review: Silence from within: Endogenous siRNAs and miRNAs. Cell, Volume 122, Issue 1, Pages 9-12 [full text] plant review: Phase change and the regulation of developmental timing in plants. Science. 2003 Jul 18;301(5631):334-6. Review. [full text]
Friday Oct 7	Paper: The Arabidopsis heterochronic gene ZIPPY is an ARGONAUTE family member. Curr Biol. 2003 Sep 30;13(19):1734-9. [full text] follow up paper by Scott Poethig
Monday Oct 10	Seminar: "Regulation of developmental timing in plants by miRNAs and transacting RNAs"

Week 3 - Jacques Cote, Laval University (Quebec)
Wednesday Oct 12	Introduction to yeast, chromatin structure and DNA damage: Reading: Chromatin remodeling and the maintenance of genome integrity. Biochim Biophys Acta. 2004 Mar 15;1677(1-3):158-64. [full text]
Friday Oct 14	Paper : Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol Cell. 2004 Dec 22;16(6):979-90. [full text] Figure showing NuA4, Ino80 and Swr1 complex
Monday Oct 17	Seminar: “ING tumor suppressor proteins are critical regulators of chromatin acetylation in eukaryotes”

Week 4 - John Carlson, Yale University
Wednesday Oct 19	Introduction to Drosophila genetics and the olfactory system Reading: The odor coding system of Drosophila Trends Genet. 2004 Sep;20(9):453-9. [full text]
Friday Oct 21	Paper: The molecular basis of odor coding in the Drosophila antenna. Cell. 2004 Jun 25;117(7):965-79. [full text]
Monday Oct 24	Seminar: “Odor reception and coding in Drosophila”

Week 5 - Linda Wordeman, Washington University
Wednesday Oct 26	Cell cycle, mitotic spindle, microtubules Reading: The mechanism, function and regulation of depolymerizing kinesins during mitosis. Trends Cell Biol. 2004 Oct;14(10):537-46. [full text]
Friday Oct 28	MCAK associates with the tips of polymerizing microtubules. J Cell Biol. 2005 May 9;169(3):391-7. [full text]
Monday Oct 31	Seminar: “The mechanism, regulation and mitotic function of Microtubule Depolymerizing Kinesins”

Week 6 - Elizabeth Chen, Johns Hopkins School of Medicine
Wednesday Nov 2	Myogenesis and myoblast fusion Reading: Unveiling the mechanisms of cell-cell fusion. Science. 2005 Apr 15;308(5720):369-73. [full text]
Friday Nov 4	Paper: Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. Cell. 2003 Sep 19;114(6):751-62. [full text]
Monday Nov 7	Seminar: “Molecular Mechanisms of Myoblast Fusion”

Week 7 - Tina Henkin, Ohio State University
Wednesday Nov 9	Techniques to analyze transcription and RNA structure in bacteria Reading: Regulation of gene expression by effectors that bind to RNA. Curr Opin Microbiol. 2004 Apr;7(2):126-31.[full text]
Friday Nov 11	A tertiary structural element in the S box leader RNAs is required for S-adenosylmethionine-directed transcription termination. Mol Microbiol. 2005 Aug;57(4):1008-21. [full text]
Monday Nov 14	Seminar: “Sensing of metabolic signals by RNA transcripts”

Week 8 - Fred Chang, Columbia University
Wednesday Nov 16	Introduction to fission yeast: Saccharomyces pombe Reading: Establishment of a cellular axis in fission yeast. Trends Genet. 2001 May;17(5):273-8. Review. [full text]
Friday Nov 18	Tea4p links microtubule plus ends with the formin for3p in the establishment of cell polarity. Dev Cell. 2005 Apr;8(4):479-91. [full text]
Nov 21 -25	Thanksgiving Break
Monday Nov 28	Seminar: “Microtubules, Actin and morphogenesis of the Fission Yeast cell”

Week 9 - Steve Lisberger, University of California (San Francisco)
Wednesday Nov 30	Techniques to study vision in mammals, the vestibulo-ocular reflex Review: Recasting the smooth pursuit eye movement system. J Neurophysiol. 2004 Feb;91(2):591-603.[full text] Also see: Lisberger lab website
Friday Dec 2	Paper 1: A sensory source for motor variation. Nature. 2005 Sep 15;437(7057):412-6. [full text] Paper 2: Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex. Nature. 2001 Jan 11;409(6817):191-4. [full text]
Monday Dec 5	Seminar: “From vision to action”