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New Reactions: Metal Catalyzed [4+4], [4+2], [5+2], [6+2], [5+2+1], [2+2+1], [4+2+2], and [6+1] Cycloadditions

Wender, P. A.; Christy, J. P. "Nickel(0)-Catalyzed [2 + 2 + 2 + 2] Cycloadditions of Terminal Diynes for the Synthesis of Substituted Cyclooctatetraenes" J. Am. Chem. Soc. 2007, 129, 13402-13403. Abstract, PDF, Supporting Information.
Wender, P. A.; Paxton, T. J.; Williams, T. J.; "Cyclopentadienone Synthesis by Rhodium(I)-Catalyzed [3 + 2] Cycloaddition Reactions of Cyclopropenones and Alkynes" J. Am. Chem. Soc. 2006, 128, 14814-14815. Abstract, PDF, Supporting Information.
Wender P. A.; Croatt, M. P.; Witulski, B. " New reactions and step economy: the total synthesis of (+/-)-salsolene oxide based on the type II transition metal-catalyzed intramolecular [4+4] cycloaddition" Tetrahedron 2006, 62, 7505-7511. Abstract, PDF.
Wender P. A.; Deschamps, N. M.; Sun R. "Rh(I)-Catalyzed C-C Bond Activation: Seven-Membered Ring Synthesis by a [6+1] Carbonylative Ring-Expansion Reaction of Allenylcyclobutanes" Agnew. Chem. Int. Ed. 2006, 45, 3957-3960. Abstract, PDF. Supporting Information.
Wender, P. A.; Christy, J. P. "Rhodium(I)-Catalyzed [4+2+2] Cycloadditions of 1,3-Dienes, Alkenes, and Alkynes for the Synthesis of Cyclooctadienes" J. Am. Chem. Soc. 2006, 128, 6530-6531. Abstract, PDF, Supporting Information.
Wender, P. A.; Haustedt, L. O.; Lim, J.; Love, J. A.; Williams, T. J.; Yoon, J.-Y. "Asymmetric Catalysis of the [5 + 2] Cycloaddition Reaction of Vinylcyclopropanes and Pi-Systems" J. Am. Chem. Soc. 2006, 128, 6302-6303. Abstract, PDF, Supporting Information.
Wender, P. A.; Croatt, M. P.; Deschamps, N. M. "Metal-Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Allenes, and CO" Angew. Chem. Int. Ed. 2006, 45, 2459-2462. Abstract, PDF, Supporting Information.
Wender P. A.; Deschamps, N. M.; Sun R. "Rh(I)-catalyzed cleavage of unactivated C-O bonds - Carbonylative rearrangement reactions of allenyl ethers to 2-carboalkoxy-1,3-dienes" Can. J. Chem. 2005, 83, 838-842. Abstract, PDF.
Wegner, H. A.; de Meijere, A.; Wender, P. A. "Transition Metal-catalyzed Intermolecular [5+2] and [5+2+1] Cycloadditions of Allenes and Vinylcyclopropanes" J. Am. Chem. Soc. 2005, 127, 6530-6531. Abstract, PDF, Supporting Information.
Wender, P. A.; Gamber, G. G.; Hubbard, R. D.; Pham, S. M.; Zhang, L. "Multicomponent Cycloadditions: The Four-component [5+1+2+1] Cycloaddition of Vinylcyclopropanes, Alkynes, and CO" J. Am. Chem. Soc. 2005, 127, 2836-2837. Abstract, PDF, Supporting Information.
Wender, P. A.; Yu, Z.; Houk, K. N. "On the Mechanism of [Rh(CO)₂Cl]₂ Catalyzed Intermolecular [5+2] Reactions Between Vinylcyclopropanes and Alkynes" J. Am. Chem. Soc. 2004, 126, 9154-9155. Abstract, PDF, Supporting Information.
Wender, P. A.; Deschamps, N. M.; Williams, T. J. "Intermolecular Dienyl Pauson-Khand Reaction" Angew. Chem. Int. Ed. 2004, 43, 3076-3079. Abstract, PDF, Supporting Information.
Wender, P. A.; Croatt, M. P.; Deschamps, N. M. "Rhodium(I)-Catalyzed [2+2+1] Cycloadditions of 1,3-Dienes, Alkenes, and CO." J. Am. Chem. Soc. 2004, 126, 5948-5949. Abstract, PDF, Supporting Information.
Wender, P. A.; Love, J. A.; Williams, T. J. "Rhodium-Catalyzed [5+2] Cycloaddition Reactions in Water" Synlett 2003, 1295-1298. Abstract, PDF.
Wender, P. A.; Deschamps, N. M.; Gamber, G. G. "The Dienyl Pauson-Khand Reaction" Angew. Chem. Int. Ed. 2003, 42, 1853-1857. Abstract, PDF, Supporting Information.
Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156. Abstract, PDF.
Wender, P. A.; Williams, T. J. "[(Arene)Rh(COD)]+ Complexes as Catalysts for [5+2] Cycloadditions" Angew. Chem. Int. Ed. 2002, 41, 4550-4553. Abstract, PDF, Supporting Information.
Wender, P. A.; Pedersen, T. M.; Scanio, M. J. C. "Transition Metal-Catalyzed Hetero-[5+2] Cycloadditions of Cyclopropyl Imines and Alkynes: Hydroazepines from Simple, Readily Available Starting Materials" J. Am. Chem. Soc. 2002, 124, 15154-15155. Abstract, PDF, Supporting Information
Wender, P. A.; Bi, F. C.; Gamber, G. G.; Gosselin, F.; Hubbard, R. D.; Scanio, M. J. C.; Sun, R.; Williams, T. J.; Zhang, L. "Toward the Ideal Synthesis. New Transition Metal-catalyzed Reactions Inspired by Novel Medicinal Leads," Pure Appl. Chem. 2002, 74, 25-31. Abstract, PDF.
Wender, P. A.; Gamber, G. G.; Hubbard, R. D.; Zhang, L. "Three Component Cycloadditions: The First Transition Metal-Catalyzed [5+2+1] Cycloaddition Reactions" J. Am. Chem. Soc. 2002, 124, 2876-2877. Abstract, PDF, Supporting Information
Wender, P. A.; Gamber, G. G.; Scanio, M. J. C."Serial [5+2]/[4+2] Cycloadditions: Facile, Preparative, Multi-Component Syntheses of Polycyclic Compounds From Simple, Readily Available Starting Materials" Angew. Chem. Int. Ed. 2001, 40, 3895. Abstract, PDF, Supporting Information
Wender, P. A.; Barzilay, C. M.; Dyckman, A. J. "The First Intermolecular Transition Metal-Catalyzed [5+2] Cycloadditions with Simple, Unactivated, Vinylcyclopropanes" J. Am. Chem. Soc. 2001, 123, 179-180. PDF, Supporting Information
Wender, P. A.; Bi, F. C.; Brodney, M. A.; Gosselin, F. "Asymmetric Synthesis of the Tricyclic Core of NGF-inducing Cyathane Diterpenes via a Transition-Metal-Catalyzed [5+2] Cycloaddition" Org. Lett. 2001, 3, 2105-2108. Abstract, PDF, Supporting Information
Wender, P. A.; Correa, A. G.; Sato, Y; Sun, R. "Transition Metal-Catalyzed [6+2] Cycloadditions of 2-Vinylcyclobutanones and Alkenes: A New Reaction for the Synthesis of Eight-Membered Rings" J. Am. Chem. Soc. 2000, 122, 7815-7816. PDF, Supporting Information
Wender, P. A.; Zhang L. "Asymmetric Total Synthesis of (+)-Aphanamol I Based on the Transition Metal Catalyzed [5+2] Cycloaddition of Allenes and Vinylcyclopropanes Org. Lett. 2000, 2, 2323-2326. Abstract, PDF, Supporting Information
Wender, P. A.; Dyckman, A. J.; Husfeld, C. O.; Scanio, M. J. C. "A New and Practical Five-Carbon Component for Metal-Catalyzed [5+2] Cycloadditions: Preparative Scale Syntheses of Substituted Cycloheptenones Org. Lett. 2000, 2, 1609-1611. Abstract, PDF, Supporting Information
Wender, P. A.; Dyckman, A. J.; Husfeld, C. O.; Kadereit, D.; Love, J. A. Rieck, H. "Transition Metal-Catalyzed [5+2] Cycloadditions with Substituted Cyclopropanes: First Studies of Regio- and Stereoselectivity" J. Am. Chem. Soc. 1999, 121, 10442-10443. PDF, Supporting Information
Wender, P. A.; Dyckman, A. J. "Transition Metal-Catalyzed [5+2] Cycloadditions of 2-Substituted-1-Vinylcyclopropanes: Catalyst Control and Reversal of Regioselectivity" Org. Lett. 1999, 1, 2089-2092. Abstract, PDF, Supporting Information
Wender, P. A. ; Fuji, M.; Husfeld, C. O.; Love, J. A. "Rhodium-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol" Org. Lett. 1999, 1, 137-139. Abstract, PDF, Supporting Information
Wender, P. A.; Glorius, F.; Husfeld, C. O.; Langkopf, E.; Love, J. A. "Transition Metal-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: First Studies of Endo-Exo Selectivity, Chemoselectivity, Relative Stereochemistry, and Chirality Transfer" J. Am. Chem. Soc. 1999, 121, 5348-5349. PDF, Supporting Information
Wender, P. A.; Love, J. A. "The Synthesis of Seven-Membered Rings: General Strategies and the Design and Development of a New Class of Cycloaddition Reactions" In Advances in Cycloaddition, Hermata, M. Ed.; JAI Press, Samford, CT, 1- 45, 1999.
Wender, P. A.; Rieck, H.; Fuji, M. "The Transition Metal-Catalyzed Intermolecular [5+2] Cycloaddition: The Homologous Diels-Alder Reaction" J. Am. Chem. Soc. 1998, 120, 10976-10977. PDF, Supporting Information
Wender, P. A.; Husfeld, C. O.; Langkopf, E; Love, J. A."First Studies of the Transition Metal-Catalyzed [5+2] Cycloadditions of Alkenes and Vinylcyclopropanes: Scope and Stereochemistry" J. Am. Chem. Soc. 1998, 120, 1940-1941. PDF, Supporting Information
Wender, P. A.; Sperandio, D. "A New and Selective Catalyst for the [5+2] Cycloaddition of Vinylcyclopropanes and Alkynes" J. Org. Chem. 1998, 63, 4164-4165. PDF, Supporting Information
Wender, P. A.; Husfeld, C. O.; Langkopf, E.; Love, J. A.; Pleuss N. "The First Metal-Catalyzed Intramolecular [5+2] Cycloadditions of Vinylcyclopropanes and Alkenes: Scope, Stereochemistry, and Asymmetric Catalysis" Tetrahedron 1998, 54, 7203-7220. Abstract, PDF.
Wender, P. A.; Smith, T. E. "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Mechanistic and Synthetic Investigations" Tetrahedron 1998, 54, 1255-1275. Abstract, PDF.
Wender, P. A.; Nuss, J. M.; Smith, D. B.; Suarezsobrino, A.; Vagberg, J.; Decosta, D.; Bordner, J. "Transition Metal Catalyzed Cycloadditions: An Intramolecular [4+4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[A,D]Cyclooctene 5-8-5 Ring Systems" J. Org. Chem. 1997, 62, 4908-4909. PDF, Supporting Information
Wender, P. A.; Smith, T.E. "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and Its Application to Yohimban Alkaloid Synthesis" J. Org. Chem. 1996, 61, 824-825. PDF, Supporting Information
Wender, P. A.; Takahashi, H.; Witulski, B. "Transition-Metal-Catalyzed [5+2] Cycloadditions of Vinylcyclopropanes and Alkynes: A Homolog of the Diels-Alder Reaction for the Synthesis of 7-Membered Rings" J. Am. Chem. Soc. 1995, 117, 4720-4721. PDF, Supporting Information
Wender, P. A.; Jenkins, T. E.; Suzuki, S. "Transition-Metal-Catalyzed Intramolecular [4+2]-Diene Allene Cycloadditions: A Convenient Synthesis of Angularly Substituted Ring-Systems With Provision for Catalyst-Controlled Chemocomplementarity and Stereocomplementarity" J. Am. Chem. Soc. 1995, 117, 1843-1844. PDF
Wender, P. A.; Smith T. E."Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Initial Studies on Stereochemistry and on Steroid and Vitamin-D Analog Syntheses" J. Org. Chem. 1995, 60, 2962-2963. PDF
Wender, P. A.; Tebbe, M. J. "Nickel(0)-Catalyzed Intramolecular [4+4] Cycloadditions: 5. The Type-II Reaction in the Synthesis of Bicyclo[5.3.1]Undecadienes" Synthesis 1991, 12, 1089-1094. PDF.
Wender, P. A.; Jenkins, T. E."Nickel-Catalyzed Intramolecular [4+2] Dienyne Cyclo-Additions: An Efficient New Method for the Synthesis of Polycycles Containing Cyclohexa-1,4-Dienes" J. Am. Chem. Soc. 1989, 111, 6432-6434. PDF
Wender, P. A.; Ihle, N. C.; Correia C.R.D. "Nickel-Catalyzed Intramolecular [4+4] Cyclo-Additions. 4. Enantioselective Total Synthesis of (+)-Asteriscanolide" J. Am. Chem. Soc. 1988, 110, 5904-5906. PDF
Wender, P. A.; White, A. W. "Organobis(Cuprates): A New Class of Reagents and Method for Spiroannelation" J. Am. Chem. Soc. 1988, 110, 2218-2223. PDF
Wender, P. A.; Ihle N. C. "Nickel-Catalyzed Intramolecular [4+4] Cycloadditions: 2. Allylic Stereoinduction and Modeling Studies in the Preparation of Bicyclo[6.4.0]Dodecadienes" Tetrahedon Lett. 1987, 28, 2451-2454. Abstract, PDF.
Wender, P. A.; Snapper, M. L. "Intramolecular Nickel Catalyzed Cycloadditions of Bis-Dienes: 3 Approaches to the Taxane Skeleton" Tetrahedon Lett. 1987, 28, 2221-2224. Abstract, PDF.
Wender, P. A.; Ihle N. C. "Nickel-Catalyzed Intramolecular [4+4] Cycloadditions: A New Method for the Synthesis of Polycycles Containing 8-Membered Rings" J. Am. Chem. Soc. 1986, 108, 4678-4679. PDF.

Complex Molecule Total Synthesis Skip to next section

Wender, P. A.; D'Angelo, N.; Elitzin, V. I.; Ernst, M.; Jackson-Ugueto, E. E.; Kowalski, J. A.; McKendry, S.; Rehfeuter, M.; Sun, R.; Voigtlaender, D. "Function-Oriented Synthesis: Studies Aimed at the Synthesis and Mode of Action of 1a-Alkyldaphnane Analogues" Org. Lett., 2007, 9, 1829-1832. Abstract, PDF, Supporting Information
Wender, P. A.; Bi, F. C.; Buschmann, N.; Gosselin, F.; Kan, C.; Kee, J.-M.; Ohmura, H. "Studies on Oxidopyrylium [5 + 2] Cycloadditions: Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins" Org. Lett., 2006, 8, 5373-5376. Abstract, PDF, Supporting Information
Wender, P. A.; Koehler, M. F. T.; Sendzik, M. "A New Synthetic Approach to the C Ring of Known as Well as Novel Bryostatin Analogues" Org. Lett., 2003, 5, 4549-4552. Abstract, PDF, Supporting Information
Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L.; Mooberry, S. L. "Synthesis and Biological Evaluation of (-)-Laulimalide Analogues" Org. Lett., 2003, 5, 3507-3509. Abstract, PDF, Supporting Information
Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156. Abstract, PDF
Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L. "Total Synthesis of (-)-Laulimilide" J. Am. Chem. Soc., 2002, 124, 4956-4967. Abstract, PDF, Supporting Information
Wender, P. A.; Bi, F. C.; Brodney, M. A.; Gosselin, F. "Asymmetric Synthesis of the Tricyclic Core of NGF-inducing Cyathane Diterpenes via a Transition-Metal-Catalyzed [5+2] Cycloaddition" Org. Lett. 2001, 3, 2105-2108. Abstract, PDF, Supporting Information
Wender, P. A.; Zhang L. "Asymmetric Total Synthesis of (+)-Aphanamol I Based on the Transition Metal Catalyzed [5+2] Cycloaddition of Allenes and Vinylcyclopropanes Org. Lett. 2000, 2, 2323-2326. Abstract, PDF, Supporting Information
Wender, P. A.; Hinkle K. W. "Synthesis and Biological Evaluation of A New Class of Bryostatin Analogues: the Role of the C20 Substituent in Protein Kinase C Binding" Tetrahedon Lett. 2000, 41, 6725-6729. PDF
Wender, P. A.; Lippa B. "Synthesis and Biological Evaluation of Bryostatin Analogues: the Role of the A-Ring" Tetrahedon Lett. 2000, 41, 1007-1011. PDF
Wender, P. A.; Fuji, M; Husfeld, C. O.; Love, J. A. "Rhodium-Catalyzed [5+2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol" Org. Lett. 1999, 1, 137-139. Abstract, PDF, Supporting Information
Wender, P. A.; Hinkle, K. W.; Koehler, M. F. T.; Lippa, B. "The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues" Med. Res. Rev. 1999, 19, 388-407. Abstract, PDF
Wender, P. A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Shiozaki, M."Synthesis of the First Members of A New Class of Biologically Active Bryostatin Analogues" J. Am. Chem. Soc. 1998, 120, 4534-4535. PDF, Supporting Information
Wender, P. A.; Dore T. M. "A Formal Synthesis of Crinipellin B Based on the Arene-Alkene Meta-Photocycloaddition Reaction" Tetrahedon Lett. 1998, 39, 8589-8592. Abstract, PDF
Wender, P. A.; Handy S. T., Wright D. L. "Towards the Ideal Synthesis" Chemistry & Industry 1997, 765.
Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass, T. E.; Houze, J. B.; Krauss, N. .E; Lee, D. S.; Marquess, D. G.; Mcgrane, P. L.; Meng, W. "The Pinene Path To Taxanes. 6. A Concise Stereocontrolled Synthesis of Taxol" J. Am. Chem. Soc. 1997, 119, 2757-2758. PDF, Supporting Information
Wender, P. A.; Rice K. D., Schnute M. E. "The First Formal Asymmetric Synthesis of Phorbol" J. Am. Chem. Soc. 1997, 119, 7897-7898. PDF, Supporting Information
Wender, P. A.; Jesudason, C. D.; Nakahira, H.; Tamura, N.; Tebbe, A. L., Ueno, Y. "The First Synthesis of a Daphnane Diterpene: the Enantiocontrolled Total Synthesis of (+)-Resiniferatoxin" J. Am. Chem. Soc. 1997, 119, 12976-12977. PDF, Supporting Information
Wender, P. A.; Nuss, J. M.; Smith, D. B.; Suarezsobrino, A.; Vagberg, J.; Decosta, D.; Bordner, J. "Transition Metal Catalyzed Cycloadditions: An Intramolecular [4+4] Cycloaddition Strategy for the Efficient Synthesis of Dicyclopenta[A,D]Cyclooctene 5-8-5 Ring Systems" J. Org. Chem. 1997, 62, 4908-4909. PDF, Supporting Information
Wender, P. A.; Badham, N. F.; Conway, S. P.; Floreancig, P. E.; Glass T. E.; Granicher, C.; Houze, J. B.; Janichen, J.; Lee, D. S.; Marquess, D. G. "The Pinene Path to Taxanes. 5. Stereocontrolled Synthesis of a Versatile Taxane Precursor" J. Am. Chem. Soc. 1997, 119, 2755-2756. PDF, Supporting Information
Wender, P. A.; Dore, T. M.; deLong, M. A. "An Arene-Alkene Photocycloaddition-Radical Cyclization Cascade: the First Syntheses of Cis,Cis,Cis,Trans-[5.5.5.5]-Fenestranes" Tetrahedon Lett. 1996, 37, 7687-7690. Abstract, PDF
Wender, P. A.; Smith, T. E. "Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: A Novel Method for the Assembly of Nitrogen Heterocycles and its Application to Yohimban Alkaloid Synthesis"J. Org. Chem. 1996, 61, 824-825. PDF, Supporting Information
Wender, P. A.; Smith T. E."Transition Metal-Catalyzed Intramolecular [4+2] Cycloadditions: Initial Studies on Stereochemistry and on Steroid and Vitamin-D Analog Syntheses" J. Org. Chem. 1995, 60, 2962-2963. PDF
Wender, P. A.; Beckham, S.; Oleary, J. G. "A 2nd-Generation Photochemically Activatable Dynemicin Analog: A Concise Synthesis and DNA Cleavage Studies" Synthesis-Stuttgart 1994, 1278-1282.
Wender, P. A.; Natchus, M. G.; Shuker, A. J. "Towards the Total Synthesis of Taxol and its Analogs," in Taxol, Science and Applications; Matthew Suffness, Ed.; CRC Press, Inc, London; Pp. 123-187, 1995.
Wender, P. A.; Mucciaro, T. P. "A New and Practical Approach to the Synthesis of Taxol and Taxol Analogs: The Pinene Path" J. Am. Chem. Soc. 1992, 114, 5878-5879. PDF
Wender, P. A.; deLong, M. A. "Synthetic Studies on Arene-Olefin Cycloadditions. XII. Total Synthesis of (+/-)-Subergorgic Acid" Tetrahedon Lett. 1990, 31, 5429-5432. Abstract, PDF
Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cycloadditions. 11. Total Synthesis of (-)-Retigeranic Acid" Tetrahedon Lett. 1990, 31, 2517-2520. Abstract, PDF
Wender, P. A.; Ternansky, R; deLong, M; Singh, S; Olivero, A; Rice, K. "Arene Alkene Cycloadditions and Organic-Synthesis" Pure Appl. Chem. 1990, 62, 1597-1602.
Wender, P. A.; McDonald, F. E. "Studies on Tumor Promoters. 9. A 2nd-Generation Synthesis of Phorbol" J. Am. Chem. Soc. 1990, 112, 4956-4958. PDF
Wender, P. A.; Siggel, L.; Nuss, J. M. "Arene-Alkene Photocycloaddition Reaction," Org. Photochem. 10, 357, 1989.
Wender, P. A.; Kogen, H.; Lee, H. Y.; Munger, J. D.; Wilhelm, R. S.; Williams, P. D. "Studies on Tumor Promoters. 8. the Synthesis of Phorbol" J. Am. Chem. Soc. 1989, 111, 8957-8958. PDF
Wender, P. A.; Ihle, N. C.; Correia C. R. D. "Nickel-Catalyzed Intramolecular [4+4] Cyclo-Additions. 4. Enantioselective Total Synthesis of (+)-Asteriscanolide" J. Am. Chem. Soc. 1988, 110, 5904-5906. PDF
Wender, P. A.; Vongeldern, T. W.; Levine, B. H. "Synthetic Studies on Arene Olefin Cyclo-Additions. 10. A Concise, Stereocontrolled Total Synthesis of (+/-)-Laurenene" J. Am. Chem. Soc. 1988, 110, 4858-4860. PDF
Wender, P. A.; Harmata, M.; Jeffrey, D.; Mukai, C.; Suffert, J. "Studies on DNA-Active Agents: the Synthesis of the Parent Carbocyclic Subunit of Neocarzinostatin Chromophore-A" Tetrahedon Lett. 1988, 29, 909-912.
Wender, P. A.; Schaus, J. M., White, A. W."General Methodology for cis-Hydroisoquinoline Synthesis .3. A Sixteen Step Synthesis of Reserpine" Heterocycles 1987, 25, 263-270.
Wender, P. A.; Fisher, K. "The Total Synthesis of (+/-)-Rudmollin .9. 7-Membered Ring Synthesis Based on Arene Olefin Cycloadditions" Tetrahedon Lett. 1986, 27, 1857-1860.
Wender, P. A.; Singh, S. K. "Synthetic Studies on Arene-Olefin Cyclo-Additions .8. Total Syntheses of (+/-)-Silphiperfol-6-Ene, (+/-)-7-Alpha-H-Silphiperfol-5-Ene and (+/-)-7-Beta-H-Silphiperfol-5-Ene" Tetrahedon Lett. 1985, 26, 5987-5990.
Wender, P. A.; Holt, D. A. "Macroexpansion Methodology .3. 8-Step Synthesis of (-)-(3Z)-Cembrene-A" J. Am. Chem. Soc. 1985, 107, 7771-7772. PDF
Wender, P. A.; Wolanin, D. J. "Total Synthesis of Quadrone and Terrecyclic Acid-A" J. Org. Chem. 1985, 50, 4418-4420. PDF
Wender, P. A.; Ternansky R. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .7. A 3-Step Total Synthesis of (+/-)-Silphinene" Tetrahedon Lett. 1985, 26, 2625-2628.
Wender, P. A.; Howbert, J. J. "Synthetic Studies on Areneolefin Cyclo-Additions .6. 2 Syntheses of (+/-)-Coriolin" Tetrahedon Lett. 1983, 24, 5325-5328.
Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .5. Total Synthesis of (+/-)-Isoiridomyrmecin" Tetrahedon Lett. 1983, 24, 4543-4546.
Wender, P. A.; Dreyer, G. B."Synthetic Studies on Arene-Olefin Cyclo-Additions .4. Total Synthesis of (+/-)-Modhephene" J. Am. Chem. Soc. 1982, 104, 5805-5807. PDF
Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions .3. Total Synthesis of +/-Hirsutene" Tetrahedon Lett. 1982, 23, 3983-3986.
Wender, P. A.; Eck, S. L."The Olefin Metathesis Trans-Annular Ene Sequence: A Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .3. Total Synthesis of (+/-)-Warburganal" Tetrahedon Lett. 1982, 23, 1871-1874.
Wender, P. A.; Dreyer, G. B. "Synthetic Studies on Arene-Olefin Cyclo-Additions .2. Total Synthesis of (+/-)-Isocomene" Tetrahedron 1981, 37, 4445-4450.
Wender, P. A.; Howbert, J. J. "Synthetic Studies on Arene-Olefin Cyclo-Additions: Total Synthesis of (-/+)-Alpha-Cedrene" J. Am. Chem. Soc. 1981, 103, 688-690. PDF
Wender, P. A.; Lechleiter, J. C. "Total Synthesis of (+/-) Isabelin" J. Am. Chem. Soc. 1980, 102, 6340-6341. PDF
Wender, P. A.; Schaus, J. M.; White, A. W. "General Methodology for cis-Hydroisoquinoline Synthesis: Synthesis of Reserpine" J. Am. Chem. Soc. 1980, 102, 6157-6159. PDF
Wender, P. A.; Letendre, L. J. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .2. Formal Eudesmane Syntheses" J. Org. Chem. 1980, 45, 367-368. PDF
Wender, P. A.; Hubbs, J. C. "Olefin Metathesis Trans-Annular Ene Sequence: Method for the Stereocontrolled Synthesis of Trans-Decalin Derivatives .1. Total Synthesis of (+/-)-Calameon" J. Org. Chem. 1980, 45, 365-367. PDF
Wender, P. A.; Eissenstat, M. A.; Filosa, M. P. "General Methodology for Pseudoguaiane Synthesis: Total Synthesis of (+/-)-Damsinic Acid and (+/-)-Confertin" J. Am. Chem. Soc. 1979, 101, 2196-2198. PDF
Wender, P. A.; Lechleiter, J. C. "Photochemically Mediated [4c+2c] Annelation: Synthesis of (+/-)-10-Epijunenol" J. Am. Chem. Soc. 1978, 100, 4321-4322. PDF

New Drug Delivery Systems Skip to next section

Wender, P. A.; Goun, E. A.; Jones, L. R.; Pillow, T. H.; Rothbard, J. B.; Shinde, R.; Contag, C. H. "Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice" Proc. Natl. Acad. Sci. USA 2007, 104, 10340-10345. Abstract, PDF, Supporting Information.
Goun, E. A.; Pillow, T. H.; Jones, L. R.; Rothbard, J. B.; Wender, P. A.; "Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real-Time Imaging" ChemBioChem 2006, 7, 1497-1515. Abstract, PDF,
Goun, E. A.; Shinde, R.; Dehnert, K. W.; Adams-Bond, A.; Wender, P. A.; Contag, C. H.; Franc, B. L. "Intracellular Cargo Delivery by an Octaarginine Transporter Adapted to Target Prostate Cancer Cells through Cell Surface Protease Activation" Bioconjugate Chem. 2007, 17(3), 787-796. Abstract, PDF,
Jones, L. R.; Goun, E. A.; Shinde, R.; Rothbard, J. B.; Contag, C. H.; Wender, P. A. "Releasable Luciferin-Transporter Conjugates: Tools for the Real-Time Analysis of Cellular Uptake and Release" J. Am. Chem. Soc. 2006, 128, 6526-6527. Abstract, PDF, Supporting Information.
Wender, P. A.; Kreider, E.; Pelkey, E. T.; Rothbard, J.; VanDeusen, C. L. "Dendrimeric Molecular Transporters: Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake" Org. Lett. 2005, 7, 4815-4818. Abstract, PDF, Supporting Information.
Rothbard, J. B.; Jessop, T. C.; Wender, P. A. "Adaptive Translocation: The Role of Hydrogen Bonding and Membrane Potential in the Uptake of Guanidinium-rich Transporters into Cells" Adv. Drug Delivery Rev. 2005, 57, 495-504. Abstract.
Rothbard, J. B.; Jessop, T. C.; Lewis, R. S.; Murray, B. A.; Wender, P. A. "Role of Membrane Potential and Hydrogen Bonding in the Mechanism of Translocation of Guanidinium-Rich Peptides into Cells" J. Am. Chem. Soc. 2004, 126, 9506-9507. Abstract, PDF, Supporting Information.
Kam, N. W. S.; Jessop, T. C.; Wender, P. A.; Dai, H. "Nanotube Molecular Transporters: Internalization of Carbon Nanotube-Protein Conjugates into Mammalian Cells" J. Am. Chem. Soc. 2004, 126, 6850-6851. Abstract, PDF, Supporting Information.
Kirschberg, T. A.; VanDeusen, C. L.; Rothbard, J. B.; Yang, M.; Wender, P. A.. "Arginine-Based Molecular Transporters: The Synthesis and Chemical Evaluation of Releasable Taxol-Transporter Conjugates" Org. Lett. 2003, 5, 3459-3462. Abstract, PDF, Supporting Information.
Rothbard, J.; Wender, P. A.; Lewis, R. S. "Transepithelial Delivery of Therapeutics Mediated by Polyguanidyl Compounds" Polymeric Mat. Sci. Eng. 2003, 89, 108.
Franc, B. L.; Mandl, S. J.; Siprashvili, Z.; Wender, P. A.; Contag, C. H. "Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy" Mol. Imag. 2003, 2, 313-323.
Siprashvili, Z; Scholl, F. A.; Oliver, S. F.; Adams, A.; Contag, C. H.; Wender, P. A.; Khavari, P. A. "Gene Transfer via Reversible Plasmid Condensation with Cysteine-flanked, Internally Spaced Arginine-rich Peptides" Human Gene Therapy, 2003, 14, 1225-1233.
Wright, L. R.; Rothbard, J. B.; Wender, P. A. "Guanidinium Rich Peptide Transporters and Drug Delivery" Current Protein & Peptide Sci., 2003, 4, 105-124.
Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156. Abstract.
Samuel, B. U.; Hearn, B.; Mack, D.; Wender, P.; Rothbard, J.; Kirisits, M. J.; Mui, E.; Wernimont, S.; Roberts, C. W.; Muench, S. P.; Rice, D. W.; Prigge, S. T.; Law, A. B.; McLeod, R. "Delivery of Antimicrobials into Parasites" Proc. Natl. Acad. Sci. USA, 2003, 100, 14281-14286. Abstract, PDF, Supporting Information.
Wender, P. A.; Rothbard, J. B.; Jessop, T. C.; Kreider, E. L.; Wylie, B. L. "Oligocarbamate Molecular Transporters: Design, Synthesis, and Biological Evaluation of a New Class of Transporters for Drug Delivery" J. Am. Chem. Soc. 2002, 124, 13382-13383. Abstract, PDF, Supporting Information. This was selected as a Science Editors' Choice.
Rothbard, J. B.; Kreider, E.; Pattabiraman, K.; Pelkey, E. T.; VanDeusen, C. L.; Wright, L.; Wylie, B. L.; Wender, P. A. "Arginine-Rich Molecular Transporters for Drugs: The Role of Backbone and Sidechain Variations on Cellular Uptake", In Cell-Penetrating Peptides: Processes and Applications, Ulo Langel, Ed.; CRC Press, Boca Raton, Fla, 141-160, 2002.
Robbins, P. B.; Oliver, S. F; Sheu, S. M.; Goodnough, J. B.; Wender, P. A.; Khavari,P. A. "Peptide Delivery to Tissue via reversibly Linked Protein transduction Sequences" BioTechniques, 2002, 33, 190-194. PDF
Rothbard, J.B.; Kreider, E.; VanDeusen, C.L.; Wright, L.; Wylie, B.L.; Wender, P. A. "Arginine-Rich Molecular Transporters for Drug Delivery: Role of Backbone Spacing in Cellular Uptake" J. Med. Chem. 2002, 3612-3618. Abstract, PDF
Wender, P. A.; Jessop, T. C.; Pattabiraman, K.; Pelkey, E. T.; VanDeusen, C. L. "An Efficient, Scalable Synthesis of the Molecular Transporter Octaarginine Via a Segment Doubling Strategy" Org. Lett. 2001, 3, 3229-3232. Abstract, PDF, Supporting Information
Chen, L; Wright, L. R.; Chen, C. H.; Oliver, S. F.; Wender, P. A.; Mochly-Rosen D. "Molecular Transporters for Peptides: Delivery of a Cardioprotective Epsilon PKC Agonist Peptide into Cells and Intact Ischemic Heart Using a Transport System, R-7" Chemistry & Biology 2001, 8, 1123-1129. Abstract, PDF
Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.; Pelkey, E. T.; Steinman, L.; Rothbard, J. B. "The Design, Synthesis, and Evaluation of Molecules That Enable or Enhance Cellular Uptake: Peptoid Molecular Transporters" Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 13003-13008. Abstract, PDF
Rothbard J. B.; Garlington, S.; Lin, Q.; Kirschberg, T.; Kreider, E.; McGrane, P. L.; Wender, P. A.; Khavari. P. A. "Conjugation of Arginine Oligomers to Cyclosporin A Facilitates Topical Delivery and inhibition of inflammation" Nature Medicine 2000, 6, 1253-1257. Abstract, PDF

Drug Design, Synthesis, and Biological Evaluation

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Wender, Paul A.; Verma, Vishal A.; Paxton, Thomas J.; Pillow, Thomas H. "Function Oriented Synthesis, Step Economy, and Drug Design", Accts. Chem. Res. 2008, 40-49. Abstract, PDF.
Wender, P. A.; Longcore, K. E. "Isolation, Structure Determination, and Anti-Cancer Activity of Apoptolidin D" Org. Lett. 2007, 9, 691-694. Abstract, PDF, Supporting Information.
Wender, P. A.; Baryza, J. L.; Hilinski, M. K.; Horan, J. C.; Kan, C.; Verma, V. A. In Drug Discovery Research: New Frontiers in the Post-Genomic Era; Huang, Z.; Ed.; Wiley-VCH: 2007. Abstract.
Wender, P. A.; Horan, J. C.; Verma, Vishal A. "Total Synthesis and Initial Biological Evaluation of New B-Ring-Modified Bryostatin Analogues" Org. Lett. 2006, 8, 5299-5302. Abstract, PDF, Supporting Information.
Wender, P. A.; Horan, J. C. "Synthesis and PKC Binding of a New Class of A-Ring Diversifiable Bryostatin Analogues Utilizing a Double Asymmetric Hydrogenation and Cross-Coupling Strategy" Org. Lett. 2006, 8, 4581-4584. Abstract, PDF, Supporting Information.
Wender, P. A.; Hilinski, M. K.; Skaanderup, P. R.; Soldermann, N. G.; Mooberry, S. L. "Pharmacophore mapping in the laulimalide series: total synthesis of a vinylogue for a late-stage metathesis diversification strategy" Org. Lett. 2006, 8, 4105-4108. Abstract, PDF, Supporting Information.
Clark, E. A.; Hills, P. M.; Davidson, B. S.; Wender, P. A.; Mooberry, S. L. "Laulimalide and synthetic laulimalide analogues are synergisitic with paclitaxel and 2-methoxyestradiol" Molecluar Pharmaceutics 2006, 3, 457-467. Abstract, PDF.
Wender, P. A.; Verma, V. A. "Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin" Org. Lett. 2006, 8, 1893-1896. Abstract, PDF, Supporting Information.
Wender, P. A.; Hilinski, M. K.; Soldermann, N.; Mooberry, S. L. "Total Synthesis and Biological Evaluation of 11-Desmethyllaulimalide, a Highly Potent Simplified Laulimalide Analogue" Org. Lett. 2006, 8, 1507-1510. Abstract, PDF, Supporting Information.
Wender, P. A.; Jankowski, O. D.; Longcore, K.; Tabet, E. A.; Seto, H.; Tomikawa, T. "Correlation of F0F1-ATPase Inhibition and Antiproliferative Activity of Apoptolidin Analogues" Org. Lett. 2006, 8, 589-592. Abstract, PDF, Supporting Information.
Wender, P. A.; Sukopp, M.; Longcore, K. "Apoptolidins B and C: Isolation, Structure Determination, and Biological Activity" Org. Lett. 2005, 7, 3025-3028. Abstract, PDF, Supporting Information.
Wender, P. A.; Clarke, M. O.; Horan, J. C. "Role of the A-Ring of Bryostatin Analogues in PKC Binding: Synthesis and Initial Biological Evaluation of New A-Ring-Modified Bryologs" Org. Lett. 2005, 7, 1995-1998. Abstract, PDF, Supporting Information.
Wender, P. A.; Baryza, J. L. "Identification of a Tunable Site in Bryostatin Analogs: C20 Bryologs Through Late Stage Diversification" Org. Lett. 2005, 7, 1177-1180. Abstract, PDF, Supporting Information.
Wender, P. A.; Hilinski, M. K.; Mayweg, A. V. W. "Late-stage Intermolecular C-H Activation for Lead Diversification: A Highly Chemoselective Oxyfunctionalization of the C-9 Position of Potent Bryostatin Analogues" Org. Lett. 2005, 7, 79-82 Abstract, PDF, Supporting Information.
Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Craske, M. L.; Horan, J. C.; Meyer, T. "Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin Analog." Curr. Drug Disc. Tech., 2004; 1, 1-11. Abstract.
Mooberry, S. L.; Randall-Hlubek, D. A.; Leal, R. M.; Hegde, S. G.; Hubbard, R. D.; Zhang, L.; Wender, P. A. "Microtubule-Stabilizing Agents Based on Designed Laulimalide Analogues" Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 8803-8808. Abstract, PDF
Wender, P. A.; Hegde, S. G.; Hubbard, R. D.; Zhang, L.; Mooberry, S. L. "Synthesis and Biological Evaluation of (-)-Laulimalide Analogues" Org. Lett., 2003, 5, 5307-5309. Abstract, PDF, Supporting Information
Wender, P. A.; Jankowski, O. D.; Tabet, E. A.; Seto, H. "Facile Synthetic Access to and Biological Evaluation of the Macrocyclic Core of Apoptolidin " Org. Lett., 2003, 5, 2299-2302. Abstract, PDF, Supporting Information
Wender, P. A.; Baryza, J. L.; Brenner, S. E.; Clarke, M. O.; Gamber, G. G.; Horan, J. C.; Jessop, T. C.; Kan, C.; Pattabiraman, K.; Williams, T. J. "Inspirations from Nature. New Reactions, New Therapeutic Leads, and New Drug Delivery Systems" Pure Appl. Chem., 2003, 75, 143-156. Abstract.
Wender, P. A.; Mayweg, A. V. W.; VanDeusen, C. L. "A Concise, Selective Synthesis of the Polyketide Spacer Domain of a Potent Bryostatin Analogue" Org. Lett., 2003; 5, 277-279. Abstract, PDF, Supporting Information
Wender, P. A.; Jankowski, O. D.; Tabet, E. A.; Seto, H. "Toward a Structure-Activity Relationship for Apoptolidin: Selective Functionalization of the Hydroxyl Group Array" Org. Lett., 2003; 5, 487-490. Abstract, PDF, Supporting Information
Wender, P. A.; Baryza, J.; Bennett, C.; Bi, C.; Brenner, S. E.; Clarke, M.; Horan, J.; Kan, C.; Lacote, E.; Lippa, B.; Nell, P.; Turner, T. "The Practical Synthesis of a Novel and Highly Potent Analog of Bryostatin" J. Am. Chem. Soc. 2002, 124, 13648-13649. Abstract, PDF, Supporting Information
Wender, P. A.; Gulledge, A. V.; Jankowski, O. D.; Seto, H. "Isoapoptolidin: Structure and Activity of the Ring-Expanded Isomer of Apoptolidin" Organic Letters, 2002, 4, 3819-3822. Abstract, PDF, Supporting Information
Wender, P. A.; Lippa B. "Synthesis and Biological Evaluation of Bryostatin Analogues: the Role of the A-Ring" Tetrahedon Lett. 2000, 41, 1007-1011. Abstract
Wender, P. A.; Hinkle, K. W.; Koehler, M. F. T.; Lippa, B. "The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues" Med. Res. Rev. 1999, 19, 388-407. Abstract, PDF
Wender, P. A.; Koehler, M. F. T.; Wright, D. L.; Irie, K. "Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): the Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers" Synthesis 1999, 1401-1406.
Wender, P. A.; Debrabander, J; Harran P. G.; Jimenez J. M.; Koehler M. F. T.; Lippa, B; Park, C. M.; Siedenbiedel, C.; Pettit, G. R. "The Design, Computer Modeling, Solution Structure, and Biological Evaluation of Synthetic Analogs of Bryostatin 1" Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 6624-6629. Abstract, PDF
Wender, P. A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T.; Lippa, B.; Park, C. M.; Shiozaki, M."Synthesis of the First Members of A New Class of Biologically Active Bryostatin Analogues" J. Am. Chem. Soc. 1998, 120, 4534-4535. PDF, Supporting Information

Protein Kinase C, Tumor Promotion, Synthetic Receptors Skip to next section

Statsuk, Alexander V.; Bai, Ruoli; Baryza, Jeremy L.; Verma, Vishal A.; Hamel, Ernest; Wender, Paul A.; Kozmin, Sergey A. "Actin is the primary cellular receptor of bistramide A" Nature Chemical Biology, 2005, 1, 383-388. PDF, Supporting Information
Hammond, C.; Shi, Y. H.; Mena, J.; Tomic, J.; Cervi, D.; He, L. W.; Millar, A. E.; DeBenedette, M.; Schuh, A. C.; Baryza, J. L.; et. al. "Effect of Serum and Antioxidants on the Immunogenicity of Protein Kinase C-activated Chronic Lymphocytic Leukemia Cells" J. Immunotherapy 2005, 28, 28-39. Abstract, PDF,.
Stone, J. C.; Stang, S. L.; Zheng, Y.; Dower, N. A.; Brenner, S. E.; Baryza, J. L.; Wender, P. A. "Synthetic Bryostatin Analogues Activate the RasGRP1 Signaling Pathway" J. Med. Chem. 2004, 47, 6638-6644. Abstract, PDF.
Baryza, J. L.; Brenner, S. E.; Craske, M. L.; Meyer, T.; Wender, P. A. "Simplified Analogs of Bryostatin with Anticancer Activity Display Greater Potency for Translocation of PKC delta-GFP" Chem. Bio. 2004, 11, 1261-1267.
Chen, L; Wright, L. R.; Chen, C. H.; Oliver, S. F.; Wender, P. A.; Mochly-Rosen D. "Molecular Transporters for Peptides: Delivery of a Cardioprotective Epsilon PKC Agonist Peptide into Cells and Intact Ischemic Heart Using a Transport System, R-7" Chemistry & Biology 2001, 8, 1123-1129. Abstract, PDF
Shindo, M.; Irie, K.; Nakahara, A,; Ohigashi, H,; Konishi, H.; Kikkawa, U.; Fukuda, H.; Wender, P. A. "Toward the Identification of Selective Modulators of Protein Kinase C (PKC) Isozymes: Establishment of A Binding Assay for PKC Isozymes Using Synthetic C1 Peptide Receptors and Identification of the Critical Residues Involved in the Phorbol Ester Binding" Bioorg. Med. Chem. 2001, 9, 2073-2081. Abstract
Tanaka M, Irie K, Nakagawa Y, Nakamura Y, Ohigashi H, Wender, P. A."The C4 Hydroxyl Group of Phorbol Esters is not Necessary for Protein Kinase C Binding" Bioorg. Med. Chem. Lett. 2001, 11, 719-722. Abstract
Nakagawa, Y.; Irie, K.; Ohigashi, H.; Hayashi, H.; Wender, P. A."Synthesis and PKC Isozyme Surrogate Binding of indothiolactam-V, A New Thioamide Analogue of Tumor Promoting indolactam-V" Bioorg. Med. Chem. Lett. 2000, 10, 2087-2090. Abstract
Wender, P. A.; Hinkle K. W. "Synthesis and Biological Evaluation of A New Class of Bryostatin Analogues: the Role of the C20 Substituent in Protein Kinase C Binding" Tetrahedon Lett. 2000, 41, 6725-6729. Abstract
Fukuda, H,; Irie, K,; Nakahara, A.; Ohigashi, H.; Wender, P. A. "Solid-Phase Synthesis, Mass Spectrometric Analysis of the Zinc-Folding, and Phorbol Ester-Binding Studies of the 116-Mer Peptide Containing the Tandem Cysteine-Rich C1 Domains of Protein Kinase C Gamma" Bioorg. Med. Chem. 1999, 7, 1213-1221.
Wender, P. A.; Kirschberg, T. A.; Williams, P. D.; Bastiaans, H. M. M.; Irie, K. "A New Class of Simplified Phorbol Ester Analogues: Synthesis and Binding To PKC and Eta PKC-C1b (Eta PKC-Cpd2)" Org. Lett. 1999, 1, 1009-1012. Abstract, PDF, Supporting Information,
Wender, P. A.; Koehler, M. F. T.; Wright, D. L.; Irie, K. "Mapping Phorbol Ester Binding Domains of Protein Kinase C (PKC): the Design, Synthesis and Biological Activity of Novel Phorbol Ester Dimers" Synthesis 1999, 1401-1406.
Irie, K.; Oie, K.; Nakahara, A.; Yanai, Y.; Ohigashi, H.; Fukuda, H.; Wender, P. A. "Synthesis and Phorbol Ester Binding of the Zinc-finger Like Sequences of All Protein Kinase C Isozymes, In Peptide Science 1998, M. Kondo, Ed.: Protein Research Foundation, Osaka , 65-68, 1999.
Wender, P. A.; Lippa, B.; Park, C. M.; Irie, K.; Nakahara, A.; Ohigashi, H. "Selective Binding of Bryostatin Analogues To the Cysteine Rich Domains of Protein Kinase C Isozymes" Bioorg. Med. Chem. Lett. 1999, 9, 1687-1690.
Fukuda, H.; Irie, K.; Nakahara, A.; Oie, K.; Ohigashi, H.; Wender, P. A. "Synthesis and Binding Studies of the 116-Mer Peptide Containing the Double Cysteine-Rich Motifs of Protein Kinase C Gamma" Tetrahedon Lett. 1998, 39, 7943-7946.
Wender, P. A.; Martincantalejo, Y.; Carpenter, A. J., Chiu, A.; Debrabander, J.; Harran, P. G.; Jimenez, J. M.; Koehler, M. F. T; Lippa, B."The Chemistry-Medicine Continuum: Synthetic, Computer, Spectroscopic and Biological Studies on New Chemotherapeutic Leads" Pure Appl. Chem. 1998, 70, 539-546.
Irie, K.; Oie, K.; Nakahara, A.; Yanai, Y.; Ohigashi, H.; Wender, P. A.; Fukuda, H.; Konishi, H.; Kikkawa, U."Molecular Basis for Protein Kinase C Isozyme-Selective Binding: the Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes" J. Am. Chem. Soc. 1998, 120, 9159-9167. Abstract, PDF, Supporting Information,
Wender, P. A.; Debrabander, J; Harran P. G.; Jimenez J. M.; Koehler M. F. T.; Lippa, B; Park, C. M.; Siedenbiedel, C.; Pettit, G. R. "The Design, Computer Modeling, Solution Structure, and Biological Evaluation of Synthetic Analogs of Bryostatin 1" Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 6624-6629. Abstract, PDF,
Irie, K.;Yanai, Y.; Ohigashi, H.; Wender, P. A. "Synthesis and Characterization of Model Peptides Incorporating the Phorbol Ester-binding Domain of Protein Kinase C," Peptide Chemistry 1996: C. Kitada (Ed.), Protein Research Foundation, Osaka, 209, 1997.
Yanai, Y.; Irie, K.; Ohigashi, H.; Wender, P. A. "Synthesis and Characterization of the First Cysteine-Rich Domain of Novel Protein Kinase C" Bioorg. Med. Chem. Lett. 1997, 7, 117-122.
Irie, K.; Yanai, Y.; Oie, K.; Ohigashi, H.; Wender, P. A. "Protein Kinase C Regulatory Domain Surrogate Peptides: Effects of Metal Ions on Folding, Phorbol Ester-Binding, and Selectivity" Bioorg. Med. Chem. Lett. 1997, 7, 965-970.
Irie, K.; Yanaim, Y.; Oie, K.; Ishizawa, J.; Nakagawa, Y.; Ohigashi, H.; Wender, P. A.; Kikkawa, U. "Comparison of Chemical Characteristics of the First and the Second Cysteine-Rich Domains of Protein Kinase C Gamma" Bioorg. Med. Chem. 1997, 5, 1725-1737.
Irie, K.; Isaka, T.; Iwata, Y.; Yanai, Y.; Nakamura, Y.; Koizumi, F.; Ohigashi, H.; Wender, P. A.; Satomi, Y.; Nishino, H. "Synthesis and Biological Activities of New Conformationally Restricted Analogues of (-)-Indolactam-V: Elucidation of the Biologically Active Conformation of the Tumor-Promoting Teleocidins" J. Am. Chem. Soc. 1996, 118, 10733-10743. Abstract, PDF, Supporting Information
Irie, K.; Yanai, Y.; Ohigashi, H.; Wender, P. A.; Miller, B. L."Synthesis and Characterization of the Second Cysteine-Rich Region of Mouse Skin PKC Eta" Bioorg. Med. Chem. Lett. 1996, 6, 353-356.
Irie, K.; Ishii, T.; Ohigashi, H.; Wender, P. A.; Miller B. L.; Takeda, N."Synthesis and Characterization of New Photolabile Phorbol Esters for Affinity Labeling of Protein Kinase C" J. Org. Chem. 1996, 61, 2164-2173. Abstract, PDF, Supporting Information
Wender, P. A.; Irie, K.; Miller, B. L."Identification, Activity, and Structural Studies of Peptides incorporating the Phorbol Ester-Binding Domain of Protein-Kinase-C" Proc. Natl. Acad. Sci. U. S. A. 1995, 92, 239-243. Abstract, PDF
Irie, K.; Koizumi, F.; Iwata, Y.; Ishii, T.; Yanai, Y.; Nakamura, Y.; Ohigashi, H.; Wender, P. A. "Synthesis and Biological-Activities of New Conformationally Fixed Analogs of (-)-indolactam-V, the Core Structure of Tumor-Promoting Teleocidins" Bioorg. Med. Chem. Lett. 1995, 5, 453-458.
Wender, P. A.; Irie, K.; Miller, B. L. "Synthesis and Binding of Photoaffinity Ligand Candidates for Protein-Kinase-C" J. Org. Chem. 1993, 58, 4179-4181.
Wender, P. A.; Cribbs, C. M. "Structural Design in Anti-tumor Compounds." In Molecular Mechanisms and Their Clinical Applications in Malignancies; Bergsagel, Daniel E. and Mak, Tak W., Eds.; Academic ; San Diego, CA, 215, 1991.
Wender, P. A.; Cribbs, C. M. "Computer Assisted Molecular Design Related to the Protein Kinase C Receptor," In Advances in Medicinal Chemistry; Maryanoff, C.A., Maryanoff, B.E., Eds.; JAI; Greenwich, CT; 1, 1-53, 1992.
Wender, P. A. "Chemsitry, Computers, and Carcinogenesis" Pure Appl. Chem., 1989, 61, 469.
Wender, P. A.; Koehler, K. F.; Sharkey, N. A.; Dellaquila, M. L.; Blumberg, P. M. "Analysis of the Phorbol Ester Pharmacophore on Protein-Kinase-C As a Guide To the Rational Design of New Classes of Analogs" Proc. Natl. Acad. Sci. U. S. A. 1986, 83, 4214-4218.
Wender, P. A.; Koehler, K.; Wilhelm, R.; Williams, P.; Keenan, R.; Lee, H. Y. "Tumor Promotion: Pharmacological and Synthetic Studies," in New Synthetic Methodology and Functionally Interesting Compounds, Z-I. Yoshida, Ed.; pp. 163-184, Elsevier Publishing Co., Amsterdam 1986.

Other Items and Group History Skip to bottom

Wender, P. A.; Jeon, R. "Photoinduced Cleavage of DNA by Bromofluoroacetophenone-pyrrolecarboxamide Conjugates" Bioorg. Med. Chem. Lett. 2003, 13, 1763-1766.
Jeon, R; Wender, P. A. "Photocleavage of DNA By 4'-Bromoacetophenone Analogs". Arch. Pharm. Res. 2001, 24, 39-43.
Irie, K.; Nakahara, A.; Ikawa, Y.; Tanaka, M.; Nakagawa, Y.; Nakamura, Y.; Ohigashi, H.; Wender, P. A."Synthesis and Tumor-Promoting Activities of 12-Epi-Phorbol-12, 13-Dibutyrate" Biosci. Biotech. Biochem. 2000, 64, 2429-2436.
Jeon, R.; Wender, P. A. "Design and Synthesis of New DNA Photocleavers, 4'-Bromoacetophenone-Pyrrolecarboxamide Hybrid Compounds." Arch. Pharm. Res. 2000, 23, 585-588.
Wender, P. A.; Jeon, R. "Bromoacetophenone-Based Photonucleases: Photoinduced Cleavage of DNA By 4'-Bromoacetophenone-Pyrrolecarboxamide Conjugates" Org. Lett. 1999, 1, 2117-2120.
Irie, K; Nakahara, A.; Ohigashi, H.; Fukuda, H.; Wender, P. A.; Konishi, H.; Kikkawa, U. "Synthesis and Phorbol Ester-Binding Studies of the individual Cysteine-Rich Motifs of Protein Kinase D" Bioorg. Med. Chem. Lett. 1999, 9, 2487-2490.
Wender, P. A.; Debrabander, J.; Harran, P. G.; Hinkle, K.W.; Lippa, B.; Pettit, G. R. "Synthesis and Biological Evaluation of Fully Synthetic Bryostatin Analogues" Tetrahedon Lett. 1998, 39, 8625-8628.
Wender, P. A.; Delong, M. A.; Wireko, F. C. "Novel Oxidative Rearrangement Product of the First Trans,cis,cis,cis-[5.5.5.5]Fenestrane Derivative" Acta Crystallographica C-Crystal Structure Comm.1997, 53, 954-956.
Wender, P. A.; Lee, D. S., Lal, T. K., Horwitz, S. B.; Rao, S."Synthesis of Novel Taxol Analogs and Evaluation of their Biological Activities" Bioorg. Med. Chem. Lett. 1997, 7, 1941-1944.
Yang, J. W.; Wender, P. A. "Synthesis of 1-(2-Naphthoyl) Benzotriazoles As Photoactivated DNA Cleaving Agents" Arch. Pharm. Res. 1997, 20, 197-199.
Touami, S. M., Poon, C. C., Wender, P. A. "Sequence Specific DNA Cleavage By Conjugates of Benzotriazoles and Minor Groove Binders" J. Am. Chem. Soc. 1997, 119, 7611-7612.
Wender, P. A. "Frontiers in Organic Synthesis: Introduction" Chem. Rev. 1996, 96, 1-2.
Wender, P. A.; Touami, S. M.; Alayrac, C; Philipp, U. C. "Triazole Photonucleases: A New Family of Light Activatable DNA Cleaving Agents" J. Am. Chem. Soc. 1996, 118, 6522-6523.
Wender, P. A.; Glass, T. E.; Krauss, N. E.; Muhlebach, M.; Peschke, B.; Rawlins, D. B. "The Pinene Path To Taxanes .4. Approaches to Taxol and Taxol Analogs Through Elaboration of Aromatic C-Ring Precursors" J. Org. Chem. 1996, 61, 7662-7663.
Wender, P. A.; Wessjohann, L. A.; Peschke, B.; Rawlins, D. B. "The Pinene Path to Taxol: Readily Accessible A-Ring Building-Blocks Based on Novel Alkyllithium and Alkenyllithium Reagents with Internal Carbonyl Groups" Tetrahedon Lett. 1995, 36, 7181-7184.
Wender, P. A.; Floreancig, P. E.; Glass, T. E.; Natchus, M. G.; Shuker, A. J.; Sutton, J. C. "Toward the Synthesis of Taxol and its Analogs: incorporation of Nonaromatic C-Rings in the Pinene Pathway" Tetrahedon Lett. 1995, 36, 4939-4942.
Wender, P. A.; Beckham, S.; Mohler, D. L. "The Intramolecular Addition of Silylated Alkynes to Aldehydes: Methodology for the Construction of Cyclic Enediynes and Its Application to Dynemicin Analogs" Tetrahedon Lett. 1995, 36, 209-212.
Wender, P. A.; Glass T. E. "The Pinene Approach to Taxanes .2. Development of A Versatile C9, C10 Linker" Synlett 1995, 516-518.
Wender, P. A.; Tebbe, M. J. "The Synthesis and Chemistry of a Simplified, Functional Analog of Neocarzinostatin Chromophore: Identification of An Intramolecular 1,5-Hydrogen Atom-Transfer Relevant to the Mechanism and Cleavage Selectivity of Diyl-Based DNA-Cleaving Agents" Tetrahedron 1994, 50, 1419-1434.
Wender, P. A.; Zercher, C. K.; Beckham, S.; Haubold, E.M.>"A Photochemically Triggered DNA-Cleaving Agent: Synthesis, Mechanistic and DNA Cleavage Studies on a New Analog of the Antitumor Antibiotic Dynemicin" J. Org. Chem. 1993, 58, 5867-5869.
Wender, P. A.; Rawlins D. B."Toward the Synthesis of the Taxol C,D Ring-System: Photolysis of Alpha-Methoxy Ketones" Tetrahedron 1992, 48, 7033-7048.
Wender, P. A.; Mascarenas, J. L."Preparation and Cycloadditions of a 4-Methoxy-3-Oxidopyrylium Ylide: A Reagent for the Synthesis of Highly Substituted 7-Membered Rings and Tetrahydrofurans" Tetrahedon Lett. 1992, 33, 2115-2118.
Wender, P. A.; Kelly R. C.; Beckham, S.; Miller, B. L. "Studies on DNA-Cleaving Agents: Computer Modeling Analysis of the Mechanism of Activation and Cleavage of Dynemicin Oligonucleotide Complexes" Proc. Natl. Acad. Sci. U. S. A. 1991, 88, 8835-8839.
Wender, P. A.; Mascarenas J. L. "Studies on Tumor Promoters .11. A New [5+2] Cycloaddition Method and Its Application To the Synthesis of BC. Ring Precursors of Phoboids"J. Org. Chem. 1991, 56, 6267-6269.
Wender, P. A.; Tebbe, M. J. "Studies on DNA Cleaving Agents: Synthesis and Chemically-Induced Cycloaromatization of a Monocyclic Neocarzinostatin Chromophore Analog" Tetrahedon Lett. 1991, 32, 4863-4866.
Wender, P. A.; Zercher, C.K. "Studies on DNA-Cleaving Agents: Synthesis of A Functional Dynemicin Analog" J. Am. Chem. Soc. 1991, 113, 2311-2313.
Wender, P. A.; Grissom J. W.; Hoffmann, U.; Mah, R. "Heteroatom Substituted Chromium Allyls: Synthetic Studies on Neocarzinostatin Chromophore Analogs" Tetrahedon Lett. 1990, 31, 6605-6608.
Wender, P. A.; Manly, C. J. "Discovery of A New Fragmentation Reaction" J. Am. Chem. Soc. 1990, 112, 8579-8581.
Wender, P. A.; Mcdonald, F. E. "Studies on Tumor Promoters .10. Synthesis of the ABC Ring-System of the Tiglianes and Daphnanes By A Zirconium-Mediated Intramolecular Enyne Carbocyclization" Tetrahedon Lett. 1990, 31, 3691-3694.
Wender, P. A.; Mckinney, J. A.; Mukai, C. "General Methodology for the Synthesis of Neocarzinostatin Chromophore Analogs: Intramolecular Chromium-Mediated Closures for Strained-Ring Synthesis"J. Am. Chem. Soc. 1990, 112, 5369-5370.
Wender, P. A.; Lee, H. Y.; Wilhelm, R. S.; Williams P. D."Studies on Tumor Promoters .7. the Synthesis of A Potentially General Precursor of the Tiglianes, Daphnanes, and Ingenanes" J. Am. Chem. Soc. 1989, 111, 8954-8957.
Wender, P. A.; Cribbs, C. M.; Koehler, M. K. F., Sharkey, N. A.; Herald, C. L.; Kamano, Y.; Pettit, G. R.; Blumberg, P. M. "Modeling of the Bryostatins to the Phorbol Ester Pharmacophore on Protein Kinase-C" Proc. Natl. Acad. Sci. U. S. A. 1988, 85, 7197-7201.
Wender, P. A.; Brighty, K."Studies on Tumor Promoters .5. Complementary 1,4-Stereocontrol in Phorboid Cycloheptene Synthesis Via the Divinylcyclopropane Rearrangement" Tetrahedon Lett. 1988, 29, 6741-6744.
Wender, P. A.; Cooper, C. B. "Indole Synthesis Based on Triazole Photochemistry: Total Synthesis of 7 Methoxymitosene" Tetrahedon Lett. 1987, 28, 6125-6128.
Wender, P. A.; Keenan, R. M., Lee, H. Y. "Studies on Tumor Promoters: the 1st Synthesis of the Phorbol Skeleton" J. Am. Chem. Soc. 1987, 109, 4390-4392.
Wender, P. A.; Correia, C. R. D."Intramolecular Photoinduced Diene-Diene Cycloadditions: A Selective Method for the Synthesis of Complex 8-Membered Rings and Polyquinanes" J. Am. Chem. Soc. 1987, 109, 2523-2525.
Wender, P. A.; Cooper, C. B."The Photochemistry of 1-Alkenylbenzotriazoles: Methodology for the Synthesis of Indoles" Tetrahedron 1986, 42, 2985-2991.
Wender, P. A.; Ternansky, R. J.; Sieburth, S.M."Macroexpansion Methodology .5. An Enolate-Accelerated Cope Rearrangement" Tetrahedon Lett. 1985, 26, 4319-4322.
Wender, P. A.; White, A. W. "Methodology for the Facile and Regio-Controlled Synthesis of Indoles" Tetrahedron 1983, 39, 3767-3776.
Wender, P. A.; Holt, D. A.; Sieburth, S. M. "Practical Method for Alpha-Alkenyl Ketone Synthesis Based on A Facile Reductive Rearrangement of Alkynyl Halohydrins" J. Am. Chem. Soc. 1983, 105, 3348-3350.
Wender, P. A.; Sieburth, S. M. "Macroexpansion Methodology: An Efficient 8 Unit Ring Expansion" Tetrahedon Lett. 1981, 22, 2471-2474.
Wender, P. A.; Erhardt, J. M.; Letendre, L.J."Reaction of Allylically Substituted Enolates With Organometallic Reagents: A Convenient Source of Enolonium Ion Equivalents" J. Am. Chem. Soc. 1981, 103, 2114-2116.
Wender, P. A.; White, A. W. "Methodology for Indole Synthesis" Tetrahedon Lett. 1981, 22, 1475-1478.
Wender, P. A.; Sieburth, S. M.; Petraitis, J. J.; Singh, S. K."Macroexpansion Methodology: Medium Ring Synthesis Based on An 8 Unit Ring Expansion Process" Tetrahedron 1981, 37, 3967-3975.
Wender, P. A.; Hillemann C. L., Szymonifka, M. J. "An Approach To the Tiglianes, Daphnanes, and Ingenanes Via the Divinylcyclopropane Rearrangement" Tetrahedon Lett. 1980, 21, 2205-2208.
Wender, P. A.; Schaus, J. M.; Torney D.C."General-Method for cis-Hydroisoquinoline Synthesis" Tetrahedon Lett. 1979 2485-2488.
Wender, P. A.; Eissenstat, M. A."Regiospecific Generation of Lithio-Enamines From Alpha,Beta-Unsaturated Imines: Alternative Method for Reduction-Alkylation of Enones" J. Am. Chem. Soc. 1978, 100, 292-294.
Wender, P. A.; Schaus, J. M. "Imine Prototropy: Synthetic Consequences in Generation of Metalloenamines" J. Org. Chem. 1978, 43, 782-784.
Wender, P. A.; Lechleiter, J. C. "Methods for Preparation of 1,5-Dienes: Metathetical Route To Medium-Sized Carbocycles" J. Am. Chem. Soc. 1977, 99, 267-268.
Wender, P. A.; Eck, S. L. "Organobiscuprates: Single-Step Spiroannelation Method" Tetrahedon Lett. 1977, 1245-1248.
Wender, P. A.; Filosa, M. P. "Facile Route to Divinylcyclopropanes: Efficient Method for Annelative Formation of Functionalized Cycloheptanes" J. Org. Chem. 1976, 41, 3490-3491.

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