Direct binding to antigen-coated beads refines the specificity and cross-reactivity of four monoclonal antibodies that recognize polymorphic epitopes of HLA class I molecules.

Hilton HG, Parham P. Tissue Antigens. 2013 Apr;81(4):212-20. doi: 10.1111/tan.12095.

Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution.

Parham P, Moffett A. Nat Rev Immunol. 2013 Feb;13(2):133-44. doi: 10.1038/nri3370. Epub 2013 Jan 21. Review.

16(th) IHIW : review of HLA typing by NGS.

De Santis D, Dinauer D, Duke J, Erlich HA, Holcomb CL, Lind C, Mackiewicz K, Monos D, Moudgil A, Norman P, Parham P, Sasson A, Allcock RJ. Int J Immunogenet. 2013 Feb;40(1):72-6. doi: 10.1111/iji.12024.

Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3.

Moesta AK, Parham P. Front Immunol. 2012;3:336. doi: 10.3389/fimmu.2012.00336. Epub 2012 Nov 22.

The IMGT/HLA database.

Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SG. Nucleic Acids Res. 2013 Jan;41(Database issue):D1222-7. doi: 10.1093/nar/gks949. Epub 2012 Oct 17.

Transdisciplinary translational science and the case of preterm birth.

Stevenson DK, Shaw GM, Wise PH, Norton ME, Druzin ML, Valantine HA, McFarland DA; March of Dimes Prematurity Research Center at Stanford University School of Medicine. J Perinatol. 2013 Apr;33(4):251-8. doi: 10.1038/jp.2012.133. Epub 2012 Oct 18.

Natural selection on marine carnivores elaborated a diverse family of classical MHC class I genes exhibiting haplotypic gene content variation and allelic polymorphism.

Hammond JA, Guethlein LA, Norman PJ, Parham P. Immunogenetics. 2012 Dec;64(12):915-33. doi: 10.1007/s00251-012-0651-z. Epub 2012 Sep 22.

Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.

Hilton HG, Vago L, Older Aguilar AM, Moesta AK, Graef T, Abi-Rached L, Norman PJ, Guethlein LA, Fleischhauer K, Parham P. J Immunol. 2012 Aug 1;189(3):1418-30. doi: 10.4049/jimmunol.1100431. Epub 2012 Jul 6.

Introducing open biology.

Glover D, Holt C, Johnson L, Parham P. Open Biol. 2011 Sep;1(1):110001. doi: 10.1098/rsob.110001. No abstract available.

Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.

Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul J, Yabe T. PLoS Pathog. 2012;8(3):e1002565. doi: 10.1371/journal.ppat.1002565. Epub 2012 Mar 8.

Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA. Philos Trans R Soc Lond B Biol Sci. 2012 Mar 19;367(1590):800-11. doi: 10.1098/rstb.2011.0266. Review.

NK cells--from bench to clinic.

Murphy WJ, Parham P, Miller JS. Biol Blood Marrow Transplant. 2012 Jan;18(1 Suppl):S2-7. doi: 10.1016/j.bbmt.2011.10.033. Review.

Review: Immunogenetics of human placentation.

Parham P, Norman PJ, Abi-Rached L, Hilton HG, Guethlein LA. Placenta. 2012 Feb;33 Suppl:S71-80. doi: 10.1016/j.placenta.2011.11.020. Epub 2011 Dec 15. Review.

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells.

Ackerman WE 4th, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NM, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJ, Kalionis B, König J, Lorenzon AR, Moffett A, Moreira de Mello JC, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramírez-Pinilla MP, Robinson WP, Rolfo A, Sadovsky Y, Soma H, Southcombe JH, Tilburgs T, Lash GE. Placenta. 2012 Feb;33 Suppl:S15-22. doi: 10.1016/j.placenta.2011.11.022. Epub 2011 Dec 10.

Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation.

Malmberg KJ, Michaëlsson J, Parham P, Ljunggren HG. Immunity. 2011 Nov 23;35(5):653-7. doi: 10.1016/j.immuni.2011.11.007.

The shaping of modern human immune systems by multiregional admixture with archaic humans.

Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202. Epub 2011 Aug 25.

Variable NK cell receptors exemplified by human KIR3DL1/S1.

Parham P, Norman PJ, Abi-Rached L, Guethlein LA. J Immunol. 2011 Jul 1;187(1):11-9. doi: 10.4049/jimmunol.0902332. Review.

Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques.

Moreland AJ, Guethlein LA, Reeves RK, Broman KW, Johnson RP, Parham P, O'Connor DH, Bimber BN. BMC Genomics. 2011 Jun 7;12:295. doi: 10.1186/1471-2164-12-295.

Rhesus macaque KIR bind human MHC class I with broad specificity and recognize HLA-C more effectively than HLA-A and HLA-B.

Older Aguilar AM, Guethlein LA, Hermes M, Walter L, Parham P. Immunogenetics. 2011 Sep;63(9):577-85. doi: 10.1007/s00251-011-0535-7. Epub 2011 May 26.

Natural variation at position 45 in the D1 domain of lineage III killer cell immunoglobulin-like receptors (KIR) has major effects on the avidity and specificity for MHC class I.

Older Aguilar AM, Guethlein LA, Abi-Rached L, Parham P. Immunogenetics. 2011 Aug;63(8):543-7. doi: 10.1007/s00251-011-0527-7. Epub 2011 May 4.

The Parham Lab

Stanford University

Publications