The Parham Lab

Epic evolutionary struggle between reproduction and immunity to infectious disease

The Parham Lab — Wed, 23 Jan 2013 06:37:40 +0000

On Scope, Bruce Goldman blogs about the latest article from Professors Parham and Moffett, recently published in Nature Reviews Immunology.

Worldwide distribution of archaic HLA-A alleles

The Parham Lab — Fri, 03 Feb 2012 08:48:15 +0000

Laurent Abi-Rached, PhD, Paul Norman PhD, Libby Guethlein, PhD: The predicted worldwide distribution of archaic HLA-A alleles illustrates the extent to which modern human immune systems have been shaped by interbreeding with archaic humans.

We like sunny days and the San Francisco Giants

The Parham Lab — Thu, 02 Feb 2012 08:49:51 +0000

The Parham Lab are interested in how peptide (cyan) selection by HLA class I (yellow) influences binding to KIR (footprint in red). We also like sunny days and the San Francisco Giants.

DNA Turning Human Story Into a Tell-All

The Parham Lab — Wed, 01 Feb 2012 08:31:45 +0000

Professor Parham is featured in Alanna Mitchell’s article, published in The New York Times on January 31, 2012.

DNA extraction from wild chimpanzees

The Parham Lab — Thu, 01 Dec 2011 08:46:10 +0000

Emily Wroblewski, PhD. Non-invasive DNA extraction from the feces of wild chimpanzees allows us to examine MHC and KIR genes in a naturally reproducing population.

NK cell KIR and HLA molecules interaction

The Parham Lab — Sat, 19 Nov 2011 08:43:02 +0000

Hugo Hilton, BVM&S. The natural killer cell receptor KIR2DL1 (blue) binds to HLA-C*04:01 (yellow). The interaction between KIR and HLA molecules has implications for innate immunity, bone marrow transplantation and placental reproduction. Dr. Hilton investigates how genetic diversity influences these interactions.

Stone Age Gene Swap

The Parham Lab — Thu, 03 Nov 2011 22:32:17 +0000

“Sex with Neanderthals gave modern humans an immune boost.” Kristin Sainani covers our latest findings in Stanford Magazine.