关于我们

斯坦福大学Pande试验室

Panda实验室是folding@home的始创小组。实验室作为斯坦福大学化学系，机构生物学系，以及斯坦福大学医学中心的一部分，主要研究蛋白质，RNA，以及纳米尺度合成高分子折叠的理论和模拟。在这个项目中，该实验室发展了用分布式计算来研究长时间尺度动力学的方法，然后将这些方法应用到蛋白质折叠中，并且开发了Folding@home项目的客户端和服务器端的程序。实验室中与Folding@home项目的有关成员名单可以在 我们的主页上找到.

相关实验室：

Folding@home的运行和进一步提高需要大量的时间精力。从一开始只有Panda教授和其他两三人，发展到现在实验室中有大概20人参与。但是在某些关键领域的研究，人手依然不够。因此，我们开始与以下实验室合作：

匹兹堡大学， Chong实验室

Chong实验室Chong实验室用计算机模拟来研究蛋白质的各种问题，特别是无结构蛋白质，和作为与癌症相关的肿瘤抑制物的p53的表现；几乎有一半的癌症都与p53的变异品种相关。Chong实验室参与了Folding@home中新AMBER的核心研发。

加州大学三藩分校，Dill实验室

Ken Dill和他的实验室是蛋白质折叠和分子生物学研究的先驱者。我们与他们在自由能计算和结构预测方面合作。

Notre Dame大学，Izaguirre实验室

The Izaguirre实验室着力于生物，计算机和应用数学交叉方向的研究。他们开发了Protomol MD软件包，对于研究和测试新算法非常有用。我们将把它和folding@home结合

弗吉尼亚大学，Shirts 实验室

弗吉尼亚大学Michael Shirts研究小组着力于开发新的模拟算法和运用计算机模拟来预测小分子的热力学性质。他们和我们合作开发新型Gromacs core。

CSULB, Sorin实验室

Sorin实验室用计算机模拟来研究蛋白质折叠及相关问题。他们和我们合作为Gromacs开发新力场参数接口。

Mediterranean Institute for Life Sciences，Zagrovic实验室

Zagrovic实验室实验室主要研究无结构蛋白质和实验性结构精细化。他们帮助开发folding@home的客户端。

志愿者

论坛管理员

翻译人员

我们也要感谢众多翻译人员帮助将Folding@home网页翻译成多种不同的语言。

开发人员

商业伙伴

因特尔 (2001-2002)

One of our earliest partners was Intel, who helped fund part of Folding@home through it's Philanthropic Peer-to-peer Program.

谷歌 (2001-2003)

Google participated in Folding@home via it's Google Compute client for FAH. Google compute was built into the Google toolbar, thus making it very easy for people to run Folding@home -- no installation, just say "yes" when asked.

索尼 (2005-present)

We have been collaborating with Sony on the Folding@home software for the PS3. This included all the components largely fron scratch, especially optimizing the scientific code to run efficiently on a PS3. The result was a really beautiful client with great performance.

ATI (2005-present)

We've been working with ATI for quite a while on our GPU core. This started with GPU1 and has carried over to GPU2.

NVIDIA (2007-present)

We've been working with NVIDIA on the GPU2 port for NVIDIA hardware. In a collaboration between NVIDIA personnel (Scott LeGrand) the Folding@home team, we have ported and optimized our code to CUDA.

Cauldron Development (2007-present)

We have been working with Cauldron Development (http://www.cauldrondevelopment.com/) to rewrite the FAH server code from scratch. This should make our code much more reliable and easier to extend. This is the software foundation for the next 10 years of the Folding@home project.

资金及其他支持

以下机构资助我们的工作

其它事项

Cosm

The Cosm project has made significant contributions to Folding@home by developing the network library (Mithral CS-SDK) used to build the client and server code. Adam Beberg is the main force behind Cosm, although there are several people involved in its development.

TINKER

The protein dynamics part of the Folding@home code is a modified version of TINKER, a powerful molecular dynamics program written by Jay Ponder's lab (in the Dept. of Biochemistry & Molecular Biophysics located at the Washington University School of Medicine in St. Louis, Missouri.). Their continual advancement of their code, including significant speed improvement in the upcoming version, will translate into further advancements in Folding@home. Please see his site for more details. If you would like to "tinker" with his source, please read and sign his license agreement.

Gromacs

We have recently incorporated and heavily modified the Gromacs molecular simulation package for Folding@home. We are continuing to work with the Gromacs developers to further improve Gromacs. For more details, see our Gromacs page.

有关于图标

Our logo is an abstract representation of our goal: to go from the protein sequence encoded in the genome to the protein's structure. The double helix on the left of the logo denotes the genome (DNA is a double helical molecule) and the arrows on the right are representations of protein structure (beta sheet structure is often drawn as ribbons with arrows).

We've recently updated this look:

We would like to thank Mark Lowe and Rob Goodlatte for all their help with the logo and web redesign. We would also like to thank Po' Smedley for his icon design.

有关屏保

Our screen saver shows real time visualizations of the simulations being performed. The molecule drawn is the current atomic configuration ("fold") of the protein being simulated on your computer and the pie chart the left shows the current progress on the work unit.

There are currently four visualization modes: Space-filling, ball-and-stick, wireframe, and alpha-trace. In ball-and-stick, each small ball represents an atom, and the sticks represent bonds between atoms. In the space-filling model, each filled sphere represents the approximate volume that the electrons occupy around each atom. In wireframe mode, only the bonds are drawn, but with the vertices colored to indicate atom identity. In all but alpha-trace mode, carbon atoms are drawn in dark gray, hydrogen atoms are drawn in light gray (although some hydrogen atoms are not drawn at all), oxygen atoms are drawn in red, nitrogen atoms are drawn in blue, and sulfur atoms are drawn in yellow. In the alpha-trace model, only one atom (the alpha-carbon) is shown per amino acid residue, in order to emphasize the overall arrangement of the peptide or protein.

Last Updated on July 23, 2008, at 03:04 PM