Frizzled Alignments

Alignment of several interesting Fz family members made by RN using the ClustalW program on DeCypher (July 15, 1999)

fz3/mouse  --------------------MAVSWIVFDLWLLTVFLG---QIGGHS--------LFSCE 
fz4/mouse  ------MAWPGTGPS---SRGAPGGVGLRLGLLLQFLLLLRPTLGFGD-----EEERRCD 
fz8/mouse  ---------MEWGYL-----LEVTSLLAALAVLQRSSG-AAAASAK---------ELACQ 
fz5/human  ---------MARPDP-----SAPPSLL--LLLLAQLVG-RAAAASK---------APVCQ 
fzd9/human -----MAVAPLRGALLLWQLLAAGGAALEIGRFD-------PERGRG--------AAPCQ 
fz1/rat  LEAPLLLGVRAQPAG---QVSG-PGQQRPPPPQPQQGG--QQYNGERG--ISIPDHGYCQ 
fz2/rat  --------MRARSAL---PRSALPRLLLPLLLLPAAGP--AQFHGEKG--ISIPDHGFCQ 
fz/Dros  ILPTLIQGVQRYDQS---PLDASPYYRSGGGLMASSG---TELDG-------LPHHNRCE 
fz2/Dros/  GLVLLLTSCRADGPL-----HSADHGMGGMGMGGHGLD-ASPAPGYGVPAIPKDPNLRCE 
  . *: 
 ________________________CRD_________________________________
fz3/mouse  	PITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC 
fz4/mouse  	PIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMC 
fz8/mouse  EITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPIC 
fz5/human  EITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCTMYTPIC 
fzd9/human AVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMC 
fz1/rat  	PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVC 
fz2/rat  	PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC 
fz/Dros  	PITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC 
fz2/Dros/  	EITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC 
  		: : * .: ** :** .* * * : : *::: * : :**: *:* 
 
 ________________CRD_________________ 
fz3/mouse  M-EYGRVTLPCRRLCQRAYSECSKLMEMFG-VPWPEDMECSRFPDCD-EPYPRLVDLN--
fz4/mouse  TEKINIPIGPCGGMCLSVKRRCEPVLREFG-FAWPDTLNCSKFPPQN-DHNHMCMEGP--
fz8/mouse  LEDYKKPLPPCRSVCERAKAGCAPLMRQYG-FAWPDRMRCDRLPEQG-NPDTLCMDYN-R
fz5/human  LPDYHKPLPPCRSVCERAKAGCSPLMRQYG-FAWPERMSCDRLPVLGRDAEVLCMDYN-R
fzd9/human TDQVSTPIPACRPMCEQARLRCAPIMEQFN-FGWPDSLDCARLPTRN-DPHALCMEAPEN
fz1/rat  T-VLEQALPPCRSLCERA-QGCEALMNKFG-FQWPDTLKCEKFPVHG--AGELCVGQNTS
fz2/rat  T-VLEQAIPPCRSICERARQGCEALMNKFG-FQWPERLRCEHFPRHG--AEQICVGQNHS
fz/Dros  T-ILERPIPPCRSLCESA-RVCEKLMKTYN-FNWPENLECSKFPVHG--GEDLCVAENTT
fz2/Dros/  LEDYHKPLPVCRSVCERARSGCAPIMQQYS-FEWPERMACEHLPLHG-DPDNLCMEQPSY
  * :* . * **. : * :* : 
 
 
fz3/mouse  --------------------------------------------------LVGDPTE---
fz4/mouse  ---GDEE--------------------------------------------VPLPHKTP-
fz8/mouse  TDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGG
fz5/human  SEATTAPPRP---FPAKP---TLP--G-----PP--------------G----APAS-GG
fzd9/human ATAGPAEPHK----GLGM----LP--------------------------VAPRPARPPG
fz1/rat  DKGTPTPSL-------------L--------------------------PEFWTSNPQHG
fz2/rat  EDG--TPAL-------------L--------------------------TTAPPSGLQPG
fz/Dros  SSA----------------------------------------------STAATPTRSVA
fz2/Dros/  TEAGSGGSSG----GSGG---SGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR-GR
  . 
 
 _________TM1____________
fz3/mouse  YSFLHVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTR
fz4/mouse  --LNCVLKCGYDAG--------LYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSR
fz8/mouse  -KTGQIANCALPCHN------PFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMER
fz5/human  -RTGQVPNCAVPCYQ------PSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMDT
fzd9/human --RSCAPRCGPGVEV-------FWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHR
fz1/rat  LGEK---DCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRR
fz2/rat  LGER---DCAAPCEPARPDGSMFFSHHHTRFARLWILTWSVLCCASTFFTVTTSLVAMQR
fz/Dros  VGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSR
fz2/Dros/  QRIAGVPNCGIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTER
  * : : :* :. * 
 ____________TM2______
fz3/mouse  FRYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASSP--------------------
fz4/mouse  FSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF-----------------------
fz8/mouse  FKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGRGGAGGAAAAGAGAAG
fz5/human  FRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACS------------------------
fzd9/human FQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD------------------------
fz1/rat  FSYPERPIIFLSGCYTAVAVAYIAGFLLE-DRVVCNDKFAE-------------------
fz2/rat  FRYPERPIIFLSGCYTMVSVAYIAGFVLQ-ERVVCNERFSE-------------------
fz/Dros  FRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVK---LG-----------
fz2/Dros/  FKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDG-----------------------
  * ****.::* . ** . :. 
 ____________TM3_________
fz3/mouse  --------------AQYKASTVTQGSHNK-ACTMLFMVLYFFTMAGSVWWVILTITWFLA 
fz4/mouse  --------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLA 
fz8/mouse  RGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLA 
fz5/human  R----------------EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLA 
fzd9/human --------------QEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLA 
fz1/rat  ----------------DGARTVAQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA 
fz2/rat  ----------------DGYRTVGQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA 
fz/Dros  --------------RLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLA 
fz2/Dros/  -------------------LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILTFTWFLA 
  : * :: : :.. ** ::: ::*: 
 ____________TM4____
fz3/mouse  AVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYF 
fz4/mouse  AGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGF 
fz8/mouse  AGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGF 
fz5/human  AAMKWGNEAIAGYGQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRRF 
fzd9/human AGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGF 
fz1/rat  AGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGF 
fz2/rat  AGMKWGHAAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNRLDPLRGF 
fz/Dros  AGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAF 
fz2/Dros/  AGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTF 
  : **. *: . ** ** * .: * : : . : *:*:. * 
 ______________TM5______ _______
fz3/mouse  VLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKE-----NQDKLVKFMIRIGVFSILYL
fz4/mouse  VVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK-DG----TKTDKLERLMVKIGVFSVLYT
fz8/mouse  VLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGP---TKTHKLEKLMIRLGLFTVLYT
fz5/human  VLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-GG----TKTDKLEKLMIRIGIFTLLYT
fzd9/human VLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-GG----TNTEKLEKLMVKIGVFSILYT
fz1/rat  VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEKLEKLMVRIGVFSVLYT
fz2/rat  VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEPLERLMVRIGVFSVLYT
fz/Dros  LILPLCIYLSIGALFLLAGFISLFRIRTVMKT-DG----KRTDKLERLMLRIGFFSGLFI
fz2/Dros/  VLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYT
  : * : :* : . :* :: : . : :: :: .*: *: 
 ___TM6______ ________
fz3/mouse  VPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMS-------RPDLILFLM 
fz4/mouse  VPATCVIACYFYEISNWALFRYSADDS--------------------------NMAVEML 
fz8/mouse  VPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARR-------------PDYAVFML 
fz5/human  VPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAK-------------PEYWVLML 
fzd9/human VPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLP----GGSVPTVAVFML 
fz1/rat  VPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMI 
fz2/rat  VPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYT-------PRTSPDFTVYMI 
fz/Dros  LPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGS----PEARPIFQIFMV 
fz2/Dros/  VPATIVIGCYLYEAAYFEDWIKALACPCAQVK--GPGKK-------------PLYSVLML 
  * : . . * :: 
 _______TM7______
fz3/mouse  KYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNT
fz4/mouse  KIFMSLLVGITSGMWIWSAKTLHTWQKCS-----------NRLVNSGKVK-----REKRG
fz8/mouse  KYFMCLVVGITSGVWVWSGKTLESWRALC-----------TRCCWASKGAAVGAGAGGSG
fz5/human  KYFMCLVVGITSGVWIWSGKTVESWRRFT-----------SRCCCRPR-------RGHK-
fzd9/human KIFMSLVVGITSGVWVWSSKTFQTWQSLC-----------YRKIAAGRARA----KACRA
fz1/rat  KYLMTLIVGITSGFWIWSGKTLNSWRKFY-----------TRLTNSK--------QGETT
fz2/rat  KYLMTLIVGITSGFWIWSGKTLHSWRKFY-----------TRLTNSR--------HGETT
fz/Dros  KYLCSMLVGVTSSVWLYSSKTMVSWRNFV-----------ERLQGKEPRT-----RAQAY
fz2/Dros/  KYFMALAVGITSGVWIWSGKTLESWRRFW-----------RRLLGAPDRTGANQALIKQR
  : : : * : .*: * ** :