<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mulligan, KA</style></author><author><style face="normal" font="default" size="100%">Fuerer, C</style></author><author><style face="normal" font="default" size="100%">Ching, W</style></author><author><style face="normal" font="default" size="100%">Fish, M</style></author><author><style face="normal" font="default" size="100%">Willert, K</style></author><author><style face="normal" font="default" size="100%">Nusse, R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility.</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the National Academy of Sciences of the United States of America</style></secondary-title><short-title><style face="normal" font="default" size="100%">Proc Natl Acad Sci U S A</style></short-title></titles><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2012 Jan 10</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.pnas.org/cgi/pmidlookup?view=long&amp;pmid=22203956</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">109</style></volume><pages><style face="normal" font="default" size="100%">370-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Lipid-modified Wnt/Wingless (Wg) proteins can signal to their target cells in a short- or long-range manner. How these hydrophobic proteins travel through the extracellular environment remains an outstanding question. Here, we report on a Wg binding protein, Secreted Wg-interacting molecule (Swim), that facilitates Wg diffusion through the extracellular matrix. Swim, a putative member of the Lipocalin family of extracellular transport proteins, binds to Wg with nanomolar affinity in a lipid-dependent manner. In quantitative signaling assays, Swim is sufficient to maintain the solubility and activity of purified Wg. In Drosophila, swim RNAi phenotypes resemble wg loss-of-function phenotypes in long-range signaling. We propose that Swim is a cofactor that promotes long-range Wg signaling in vivo by maintaining the solubility of Wg.</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/22203956?dopt=Abstract</style></custom1><custom3><style face="normal" font="default" size="100%">22203956</style></custom3><custom4><style face="normal" font="default" size="100%">2012-01-10 12:00:00</style></custom4></record></records></xml>