<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Leucht, P</style></author><author><style face="normal" font="default" size="100%">Minear, S</style></author><author><style face="normal" font="default" size="100%">ten Berge, D</style></author><author><style face="normal" font="default" size="100%">Nusse, R</style></author><author><style face="normal" font="default" size="100%">Helms, J A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Translating insights from development into regenerative medicine: the function of Wnts in bone biology.</style></title><secondary-title><style face="normal" font="default" size="100%">Semin Cell Dev Biol</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">5</style></number><pub-location><style face="normal" font="default" size="100%">Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.</style></pub-location><volume><style face="normal" font="default" size="100%">19</style></volume><pages><style face="normal" font="default" size="100%">434–443</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">The Wnt pathway constitutes one of the most attractive candidates for modulating skeletal tissue regeneration based on its functions during skeletal development and homeostasis. Wnts participate in every stage of skeletogenesis, from the self-renewal and proliferation of skeletal stem cells to the specification of osteochondroprogenitor cells and the maturation of chondrocytes and osteoblasts. We propose that the function of Wnts depend upon a skeletogenic cell's state of differentiation. In this review we summarize recent data with a focus on the roles of Wnt signaling in mesenchymal stem cell fate, osteoprogenitor cell differentiation, chondrocyte maturation, bone remodeling, and bone regeneration.</style></abstract></record></records></xml>