A dermal HOX transcriptional program regulates site-specific epidermal fate.
Submitted by admin on Thu, 10/14/2010 - 22:44
| Title | A dermal HOX transcriptional program regulates site-specific epidermal fate. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler SH, Nusse R, Helms JA, Chang HY |
| Journal | Genes Dev |
| Volume | 22 |
| Pagination | 303–307 |
| Date Published | Feb |
| ISSN | 0890-9369 (Print); 0890-9369 (Linking) |
| Abstract | Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene, is abrogated by depletion of HOXA13, but rescued by addition of WNT5A. Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration. |
| DOI | 10.1101/gad.1610508 |
