Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade.
Submitted by Anonymous on Fri, 09/23/2022 - 02:35
| Title | Wnt signaling regulates hepatocyte cell division by a transcriptional repressor cascade. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Jin Y, Anbarchian T, Wu P, Sarkar A, Fish M, Peng WC, Nusse R |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 119 |
| Issue | 30 |
| Pagination | e2203849119 |
| Date Published | 2022 Jul 26 |
| ISSN | 0027-8424 |
| Abstract | Cell proliferation is tightly controlled by inhibitors that block cell cycle progression until growth signals relieve this inhibition, allowing cells to divide. In several tissues, including the liver, cell proliferation is inhibited at mitosis by the transcriptional repressors E2F7 and E2F8, leading to formation of polyploid cells. Whether growth factors promote mitosis and cell cycle progression by relieving the E2F7/E2F8-mediated inhibition is unknown. We report here on a mechanism of cell division control in the postnatal liver, in which Wnt/β-catenin signaling maintains active hepatocyte cell division through , a Wnt target gene. The TBX3 protein directly represses transcription of and , thereby promoting mitosis. This cascade of sequential transcriptional repressors, initiated by Wnt signals, provides a paradigm for exploring how commonly active developmental signals impact cell cycle completion. |
| URL | https://www.pnas.org/doi/abs/10.1073/pnas.2203849119?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed |
| DOI | 10.1073/pnas.2203849119 |
| Short Title | Proc Natl Acad Sci U S A |
