The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators.
Submitted by Anonymous on Mon, 07/18/2022 - 12:35
| Title | The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Rim EY, Clevers H, Nusse R |
| Journal | Annual review of biochemistry |
| Volume | 91 |
| Pagination | 571-598 |
| Date Published | 2022 Jun 21 |
| ISSN | 0066-4154 |
| Abstract | The Wnt pathway is central to a host of developmental and disease-related processes. The remarkable conservation of this intercellular signaling cascade throughout metazoan lineages indicates that it coevolved with multicellularity to regulate the generation and spatial arrangement of distinct cell types. By regulating cell fate specification, mitotic activity, and cell polarity, Wnt signaling orchestrates development and tissue homeostasis, and its dysregulation is implicated in developmental defects, cancer, and degenerative disorders. We review advances in our understanding of this key pathway, from Wnt protein production and secretion to relay of the signal in the cytoplasm of the receiving cell. We discuss the evolutionary history of this pathway as well as endogenous and synthetic modulators of its activity. Finally, we highlight remaining gaps in our knowledge of Wnt signal transduction and avenues for future research. |
| URL | https://arjournals.annualreviews.org/doi/10.1146/annurev-biochem-040320-103615?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed |
| DOI | 10.1146/annurev-biochem-040320-103615 |
| Short Title | Annu Rev Biochem |
