Wnt signalling: conquering complexity.
Submitted by Anonymous on Thu, 10/25/2018 - 23:35
| Title | Wnt signalling: conquering complexity. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Wiese KE, Nusse R, van Amerongen R |
| Journal | Development (Cambridge, England) |
| Volume | 145 |
| Issue | 12 |
| Date Published | 2018 Jun 26 |
| ISSN | 0950-1991 |
| Abstract | The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. Here, we specifically highlight the instrumental role that developmental biology has played throughout. We take the reader on a journey, starting with developmental genetics studies that identified some of the main molecular players, through developmental model organisms that helped unravel their biochemical function and cell biological activities. Culminating in complex analyses of stem cell fate and dynamic tissue growth, these efforts beautifully illustrate how different disciplines provided missing pieces of a puzzle. Together, they have shaped our mechanistic understanding of the Wnt pathway as a conserved signalling process in development and disease. Today, researchers are still uncovering additional roles for Wnts and other members of this multifaceted signal transduction pathway, opening up promising new avenues for clinical applications. |
| URL | http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=29945986 |
| DOI | 10.1242/dev.165902 |
| Short Title | Development |
