Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.
Submitted by Anonymous on Sun, 10/01/2017 - 02:35
| Title | Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Nusse R, Clevers H |
| Journal | Cell |
| Volume | 169 |
| Issue | 6 |
| Pagination | 985-999 |
| Date Published | 2017 Jun 1 |
| ISSN | 0092-8674 |
| Abstract | The WNT signal transduction cascade is a main regulator of development throughout the animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult mammals. Unsurprisingly, mutated Wnt pathway components are causative to multiple growth-related pathologies and to cancer. Here, we describe the core Wnt/β-catenin signaling pathway, how it controls stem cells, and contributes to disease. Finally, we discuss strategies for Wnt-based therapies. |
| URL | https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(17)30547-0 |
| DOI | 10.1016/j.cell.2017.05.016 |
| Short Title | Cell |
