Alternative wnt signaling is initiated by distinct receptors.
Submitted by admin on Thu, 10/14/2010 - 22:44
| Title | Alternative wnt signaling is initiated by distinct receptors. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | van Amerongen R, Mikels A, Nusse R |
| Journal | Sci Signal |
| Volume | 1 |
| Pagination | re9 |
| ISSN | 1937-9145 (Electronic) |
| Abstract | An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example. |
| DOI | 10.1126/scisignal.135re9 |
