The Wnt gene family in tumorigenesis and in normal development.
Submitted by admin on Thu, 10/14/2010 - 22:44
| Title | The Wnt gene family in tumorigenesis and in normal development. |
| Publication Type | Journal Article |
| Year of Publication | 1992 |
| Authors | Nusse R |
| Journal | J Steroid Biochem Mol Biol |
| Volume | 43 |
| Pagination | 9–12 |
| Date Published | Sep |
| ISSN | 0960-0760 (Print); 0960-0760 (Linking) |
| Abstract | Various members of the Wnt gene family have been identified as activated oncogenes in mouse mammary tumors. We show that some tumors are oligoclonal for activation of a Wnt gene, and clonal variation when those tumors are transplanted to become hormone-independent. The normal function of many Wnt genes is to control pattern formation in early embryos, as shown by expression profiles and by mutant analysis. |
