Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene.
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| Title | Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. |
| Publication Type | Journal Article |
| Year of Publication | 1993 |
| Authors | Roelink H, Wang J, Black DM, Solomon E, Nusse R |
| Journal | Genomics |
| Volume | 17 |
| Pagination | 790–792 |
| Date Published | Sep |
| ISSN | 0888-7543 (Print); 0888-7543 (Linking) |
| Abstract | In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. Here we report on the isolation of a human homolog, WNT3. A genomic clone was isolated by use of mouse Wnt-3 sequences as a probe, after which cDNA containing most of the protein-encoding domain of the human gene was obtained by PCR. Comparison between the deduced mouse and human WNT-3 protein sequences showed four changes in 333 amino acids. WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors. |
| DOI | 10.1006/geno.1993.1412 |
