Beta-catenin: a key mediator of Wnt signaling.
Submitted by admin on Thu, 10/14/2010 - 22:44
| Title | Beta-catenin: a key mediator of Wnt signaling. |
| Publication Type | Journal Article |
| Year of Publication | 1998 |
| Authors | Willert K, Nusse R |
| Journal | Curr Opin Genet Dev |
| Volume | 8 |
| Pagination | 95–102 |
| Date Published | Feb |
| ISSN | 0959-437X (Print); 0959-437X (Linking) |
| Abstract | Beta-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of several developmental processes. beta-catenin activity is controlled by a large number of binding partners that affect the stability and the localization of beta-catenin and is thereby able to participate in such varying processes as gene expression and cell adhesion. Activating mutations in beta-catenin and in components regulating its stability can contribute to the formation of certain tumors. |
