Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex.
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Title | Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Yamazaki H, Nusse R |
Journal | Mech Dev |
Volume | 119 |
Pagination | 115–119 |
Date Published | Nov |
ISSN | 0925-4773 (Print); 0925-4773 (Linking) |
Abstract | In a yeast two-hybrid screen using the Drosophila Axin protein as a bait, we have identified a Drosophila homolog of CAP, a component of the glucose transport regulatory complex. Through alternative splicing, the DCAP gene generates a set of five different proteins with unique N-terminal sequences and a common C-terminal SH3 domain. DCAP is predominantly expressed in the midgut and fat bodies of late-stage embryos, suggesting a role in insulin-mediated glucose transport in these organs. |