2014
Development of Selective Inhibitors for Aldehyde Dehydrogenases based on Substituted Indole-2,3-diones [PubMed]
Kimble-Hill AC, Parajuli B, Chen CH, Mochly-Rosen D, Hurley TD
J Med Chem. 2014 Jan 20. [Epub ahead of print]
Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats [PubMed]
Zambelli VO(1), Fernandes AC(1), Gutierrez VP(1), Ferreira JC(2), Parada CA(3), Mochly-Rosen D(4), Cury Y(1)
PLoS One. 2014 Mar 4;9(3):e90576. doi: 10.1371/journal.pone.0090576. eCollection 2014
Targeting aldehyde dehydrogenase 2: new therapeutic opportunities [PubMed]
Chen CH, Ferreira JC, Gross ER, Mochly-Rosen D
Physiol Rev. 2014 Jan;94(1):1-34. doi: 10.1152/physrev.00017.2013
2013
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration [PubMed]
Guo X, Disatnik MH, Monbureau M, Shamloo M, Mochly-Rosen D, Qi X
J Clin Invest. 2013 Nov 15. pii: 70911. doi: 10.1172/JCI70911. [Epub ahead of print]
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction [PubMed]
Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D
J Am Heart Assoc. 2013 Oct 8;2(5):e000461. doi: 10.1161/JAHA.113.000461
Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C [PubMed]
Gross ER, Hsu AK, Urban TJ, Mochly-Rosen D, Gross GJ
Basic Res Cardiol. 2013 Sep;108(5):381. doi: 10.1007/s00395-013-0381-x. Epub 2013 Aug 28
A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth [PubMed]
Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT
Clin Cancer Res. 2013 Aug 15;19(16):4455-64. doi: 10.1158/1078-0432.CCR-13-0127. Epub 2013 Jun 28
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase Cδ (PKCδ) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury [PubMed]
Yogalingam G, Hwang S, Ferreira JC, Mochly-Rosen D
J Biol Chem. 2013 Jun 28;288(26):18947-60. doi: 10.1074/jbc.M113.466870. Epub 2013 May 7
Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis [PubMed]
Solito R, Corti F, Chen CH, Mochly-Rosen D, Giachetti A, Ziche M, Donnini S
J Cell Sci. 2013 May 1;126(Pt 9):1952-61. doi: 10.1242/jcs.117184. Epub 2013 Feb 27
Translational medicine: mitigating risks for investigators [PubMed]
Mann DL, Mochly-Rosen D
Nat Rev Drug Discov. 2013 May;12(5):327-8. doi: 10.1038/nrd4005
In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate [PubMed]
Josan S, Xu T, Yen YF, Hurd R, Ferreira J, Chen CH, Mochly-Rosen D, Pfefferbaum A, Mayer D, Spielman D
NMR Biomed. 2013 Jun;26(6):607-12. doi: 10.1002/nbm.2897. Epub 2012 Dec 6
Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice [PubMed]
Sun X, Budas GR, Xu L, Barreto GE, Mochly-Rosen D, Giffard RG
J Neurosci Res. 2013 Jun;91(6):799-807. doi: 10.1002/jnr.23186. Epub 2013 Feb 21
Focus on: the cardiovascular system: what did we learn from the French (paradox)? [PubMed]
Mochly-Rosen D, Zakhari S
Alcohol Res Health. 2010;33(1):76-86
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity [PubMed]
Qi X, Qvit N, Su YC, Mochly-Rosen D
J Cell Sci. 2013 Feb 1;126(Pt 3):789-802. doi: 10.1242/jcs.114439. Epub 2012 Dec 13
Exercise training restores cardiac protein quality control in heart failure [PubMed]
Campos JC, Queliconi BB, Dourado PM, Cunha TF, Zambelli VO, Bechara LR, Kowaltowski AJ, Brum PC, Mochly-Rosen D, Ferreira JC
PLoS One. 2012;7(12):e52764. doi: 10.1371/journal.pone.0052764. Epub 2012 Dec 27
2012
Protein kinase C, an elusive therapeutic target? [PubMed]
Mochly-Rosen D, Das K, Grimes KV
Nat Rev Drug Discov. 2012 Dec;11(12):937-57. doi: 10.1038/nrd3871
Activation of εPKC reduces reperfusion arrhythmias and improves recovery from ischemia: optical mapping of activation patterns in the isolated guinea-pig heart [PubMed]
Restivo M, Kozhevnikov DO, Qu YS, Yue Y, Mochly-Rosen D, El-Sherif N, Boutjdir M
Biochem Biophys Res Commun. 2012 Sep 21;426(2):237-41. doi: 10.1016/j.bbrc.2012.08.073. Epub 2012 Aug 22
Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption [PubMed]
Chang YC, Chiu YF, Lee IT, Ho LT, Hung YJ, Hsiung CA, Quertermous T, Donlon T, Lee WJ, Lee PC, Chen CH, Mochly-Rosen D, Chuang LM
BMC Cardiovasc Disord. 2012 Jul 29;12:58
Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice [PubMed]
Ning S, Budas GR, Churchill EN, Chen CH, Knox SJ, Mochly-Rosen D
Radiat Res. 2012 Jul;178(1):69-74. Epub 2012 Mar 9
Identification of εPKC targets during cardiac ischemic injury [PubMed]
Budas G, Costa HM Jr, Ferreira JC, Teixeira da Silva Ferreira A, Perales J, Krieger JE, Mochly-Rosen D, Schechtman D
Circ J. 2012;76(6):1476-85. Epub 2012 Mar 27
Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes [PubMed]
Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG
Oncogene. 2012 May 17;31(20):2593-600. doi: 10.1038/onc.2011.428. Epub 2011 Sep 26
Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3 [PubMed]
Ferreira JC, Boer BN, Grinberg M, Brum PC, Mochly-Rosen D
PLoS One. 2012;7(3):e33175. doi: 10.1371/journal.pone.0033175. Epub 2012 Mar 30
2011
Highly Specific Modulators of Protein Kinase C Localization: Applications to Heart Failure [PubMed]
Qvit N, Mochly-Rosen D
Drug Discov Today Dis Mech. 2010 Summer;7(2):e87-e93
Regulation of mitochondrial processes: a target for heart failure [PubMed]
Palaniyandi SS, Qi X, Yogalingam G, Ferreira JC, Mochly-Rosen D
Drug Discov Today Dis Mech. 2010 Summer;7(2):e95-e102
Regulation of cardiac excitability by protein kinase C isozymes [PubMed]
Ferreira JC, Mochly-Rosen D, Boutjdir M
Front Biosci (Schol Ed). 2012 Jan 1;4:532-46
Nitroglycerin use in myocardial infarction patients [PubMed]
Ferreira JC, Mochly-Rosen D
Circ J. 2012;76(1):15-21. Epub 2011 Nov 1
Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases [PubMed]
Khanna M, Chen CH, Kimble-Hill A, Parajuli B, Perez-Miller S, Baskaran S, Kim J, Dria K, Vasiliou V, Mochly-Rosen D, Hurley TD
J Biol Chem. 2011 Dec 16;286(50):43486-94. doi: 10.1074/jbc.M111.293597. Epub 2011 Oct 21
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo [PubMed]
Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT
Clin Cancer Res. 2011 Dec 1;17(23):7265-72. doi: 10.1158/1078-0432.CCR-11-0179. Epub 2011 Oct 13
Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy [PubMed]
Ferreira JC, Koyanagi T, Palaniyandi SS, Fajardo G, Churchill EN, Budas G, Disatnik MH, Bernstein D, Brum PC, Mochly-Rosen D
J Mol Cell Cardiol. 2011 Dec;51(6):980-7. doi: 10.1016/j.yjmcc.2011.08.025. Epub 2011 Sep 2
ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance [PubMed]
Sun L, Ferreira JC, Mochly-Rosen D
Sci Transl Med. 2011 Nov 2;3(107):107ra111. doi: 10.1126/scitranslmed.3002067
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways [PubMed]
Fajardo G, Zhao M, Berry G, Wong LJ, Mochly-Rosen D, Bernstein D
J Mol Cell Cardiol. 2011 Nov;51(5):781-9. doi: 10.1016/j.yjmcc.2011.06.019. Epub 2011 Jul 2
Myocardial salvage in acute myocardial infarction--challenges in clinical translation [PubMed]
Mochly-Rosen D, Grimes KV
J Mol Cell Cardiol. 2011 Oct;51(4):451-3. doi: 10.1016/j.yjmcc.2011.08.002. Epub 2011 Aug 12
βIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure [PubMed]
Ferreira JC, Brum PC, Mochly-Rosen D
J Mol Cell Cardiol. 2011 Oct;51(4):479-84. doi: 10.1016/j.yjmcc.2010.10.020. Epub 2010 Oct 28
PKCβII inhibition attenuates myocardial infarction induced heart failure and is associated with a reduction of fibrosis and pro-inflammatory responses [PubMed]
Palaniyandi SS, Ferreira JC, Brum PC, Mochly-Rosen D
J Cell Mol Med. 2011 Aug;15(8):1769-77. doi: 10.1111/j.1582-4934.2010.01174.x
Therapeutic potential for protein kinase C inhibitor in vascular restenosis [PubMed]
Ding RQ, Tsao J, Chai H, Mochly-Rosen D, Zhou W
J Cardiovasc Pharmacol Ther. 2011 Jun;16(2):160-7. doi: 10.1177/1074248410382106. Epub 2010 Dec 23
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells [PubMed]
Kim J, Koyanagi T, Mochly-Rosen D
Prostate. 2011 Jun 15;71(9):946-54. doi: 10.1002/pros.21310. Epub 2010 Nov 23
Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells [PubMed]
Ding Q, Chai H, Mahmood N, Tsao J, Mochly-Rosen D, Zhou W
J Vasc Surg. 2011 Apr;53(4):1044-51. doi: 10.1016/j.jvs.2010.10.117. Epub 2011 Jan 31
Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo [PubMed]
Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D
Mol Biol Cell. 2011 Jan 15;22(2):256-65. doi: 10.1091/mbc.E10-06-0551. Epub 2010 Nov 30
2010
Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting [PubMed]
Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S
Circulation. 2010 Sep 14;122(11 Suppl):S170-8. doi: 10.1161/CIRCULATIONAHA.109.927640
Mitochondrial aldehyde dehydrogenase and cardiac diseases [PubMed]
Chen CH, Sun L, Mochly-Rosen D
Cardiovasc Res. 2010 Oct 1;88(1):51-7. doi: 10.1093/cvr/cvq192. Epub 2010 Jun 16
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury [PubMed]
Budas GR, Churchill EN, Disatnik MH, Sun L, Mochly-Rosen D
Cardiovasc Res. 2010 Oct 1;88(1):83-92. doi: 10.1093/cvr/cvq154. Epub 2010 Jun 16
Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells [PubMed]
Koda K, Salazar-Rodriguez M, Corti F, Chan NY, Estephan R, Silver RB, Mochly-Rosen D, Levi R
Circulation. 2010 Aug 24;122(8):771-81. doi: 10.1161/CIRCULATIONAHA.110.952481. Epub 2010 Aug 9
Non-volume-loaded heart provides a more relevant heterotopic transplantation model [PubMed]
Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S
Transpl Immunol. 2010 May;23(1-2):65-70. doi: 10.1016/j.trim.2010.04.005. Epub 2010 Apr 18
Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice [PubMed]
Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D
J Mol Cell Cardiol. 2010 Apr;48(4):757-64. doi: 10.1016/j.yjmcc.2009.10.030. Epub 2009 Nov 11
deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification [PubMed]
Monti M, Donnini S, Giachetti A, Mochly-Rosen D, Ziche M
J Mol Cell Cardiol. 2010 Apr;48(4):746-56. doi: 10.1016/j.yjmcc.2009.11.002. Epub 2009 Nov 11
Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant [PubMed]
Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD
Nat Struct Mol Biol. 2010 Feb;17(2):159-64. doi: 10.1038/nsmb.1737. Epub 2010 Jan 10
2009
Ischaemic preconditioning improves proteasomal activity and increases the degradation of deltaPKC during reperfusion [PubMed]
Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D
Cardiovasc Res. 2010 Jan 15;85(2):385-94. doi: 10.1093/cvr/cvp334. Epub 2009 Oct 10
Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? [PubMed]
Budas GR, Disatnik MH, Mochly-Rosen D
Trends Cardiovasc Med. 2009 Jul;19(5):158-64. doi: 10.1016/j.tcm.2009.09.003
Protein kinase C in heart failure: a therapeutic target? [PubMed]
Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D
Cardiovasc Res. 2009 May 1;82(2):229-39. doi: 10.1093/cvr/cvp001. Epub 2009 Jan 24
Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model [PubMed]
Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D
Int J Cardiol. 2009 Apr 3;133(2):256-9. doi: 10.1016/j.ijcard.2007.11.021. Epub 2008 Feb 1
Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats [PubMed]
Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK
Brain Res. 2009 Jan 28;1251:256-61. doi: 10.1016/j.brainres.2008.11.051. Epub 2008 Nov 27
Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2 [PubMed]
Churchill EN, Disatnik MH, Mochly-Rosen D
J Mol Cell Cardiol. 2009 Feb;46(2):278-84. doi: 10.1016/j.yjmcc.2008.09.713. Epub 2008 Oct 17
Rationally designed peptide regulators of protein kinase C [PubMed]
Churchill EN, Qvit N, Mochly-Rosen D
Trends Endocrinol Metab. 2009 Jan;20(1):25-33. doi: 10.1016/j.tem.2008.10.002. Epub 2008 Dec 4
Ethanol for cardiac ischemia: the role of protein kinase c [PubMed]
Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D
Ther Adv Cardiovasc Dis. 2008 Dec;2(6):469-83. doi: 10.1177/1753944708094735
2008
Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure [PubMed]
Palaniyandi SS, Inagaki K, Mochly-Rosen D
J Mol Cell Cardiol. 2008 Dec;45(6):779-86. doi: 10.1016/j.yjmcc.2008.08.009. Epub 2008 Sep 4
Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart [PubMed]
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D
Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554
Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis [PubMed]
Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D
Cancer Res. 2008 Aug 15;68(16):6831-9. doi: 10.1158/0008-5472.CAN-07-6195
Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats [PubMed]
Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H220-6. doi: 10.1152/ajpheart.00289.2008. Epub 2008 May 16
epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury [PubMed]
Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D
Neurosci Lett. 2008 Aug 15;441(1):120-4. doi: 10.1016/j.neulet.2008.05.080. Epub 2008 May 27
Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure [PubMed]
Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D
Hypertension. 2008 Jun;51(6):1565-9. doi: 10.1161/HYPERTENSIONAHA.107.109637. Epub 2008 Apr 14
Islet cell survival during isolation improved through protein kinase C epsilon activation [PubMed]
Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ
Transplant Proc. 2008 Mar;40(2):375-8. doi: 10.1016/j.transproceed.2008.01.014
Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways [PubMed]
Yao L, Fan P, Jiang Z, Gordon A, Mochly-Rosen D, Diamond I
Mol Pharmacol. 2008 Apr;73(4):1105-12. doi: 10.1124/mol.107.042580. Epub 2008 Jan 17
The PKCdelta -Abl complex communicates ER stress to the mitochondria - an essential step in subsequent apoptosis [PubMed]
Qi X, Mochly-Rosen D
J Cell Sci. 2008 Mar 15;121(Pt 6):804-13. doi: 10.1242/jcs.024653. Epub 2008 Feb 19
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction [PubMed]
Direct Inhibition of delta-Protein Kinase C Enzyme to Limit Total Infarct Size in Acute Myocardial Infarction (DELTA MI) Investigators, Bates E, Bode C, Costa M, Gibson CM, Granger C, Green C, Grimes K, Harrington R, Huber K, Kleiman N, Mochly-Rosen D, Roe M, Sadowski Z, Solomon S, Widimsky P
Circulation. 2008 Feb 19;117(7):886-96. doi: 10.1161/CIRCULATIONAHA.107.759167. Epub 2008 Feb 4
PKC isozymes in chronic cardiac disease: possible therapeutic targets? [PubMed]
Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D
Annu Rev Pharmacol Toxicol. 2008;48:569-99
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats [PubMed]
Qi X, Inagaki K, Sobel RA, Mochly-Rosen D
J Clin Invest. 2008 Jan;118(1):173-82
2007
Induced fit and wit: celebrating the life of Daniel E. Koshland, Jr. (1920 - 2007) [PubMed]
Newton AC, Mochly-Rosen D
IUBMB Life. 2007 Dec;59(12):741-3
The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury [PubMed]
Churchill EN, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1040-2
Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic [PubMed]
Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1021-6
Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage [PubMed]
Budas GR, Mochly-Rosen D
Biochem Soc Trans. 2007 Nov;35(Pt 5):1052-4
deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart [PubMed]
Qi X, Vallentin A, Churchill E, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Oct;43(4):420-8. Epub 2007 Aug 8
Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model [PubMed]
Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Oct;43(4):517-22. Epub 2007 Jun 21
Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia [PubMed]
Shimohata T, Zhao H, Sung JH, Sun G, Mochly-Rosen D, Steinberg GK
J Cereb Blood Flow Metab. 2007 Aug;27(8):1463-75. Epub 2007 Feb 7
Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury [PubMed]
Budas GR, Churchill EN, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):523-36. Epub 2007 Apr 29
Happy birthday protein kinase C: past, present and future of a superfamily [PubMed]
Battaini F, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):461-6. Epub 2007 May 18
Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function [PubMed]
Kheifets V, Mochly-Rosen D
Pharmacol Res. 2007 Jun;55(6):467-76. Epub 2007 May 3
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase [PubMed]
Siwko S, Mochly-Rosen D
Int J Biochem Cell Biol. 2007;39(5):978-87. Epub 2007 Jan 24
Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide [PubMed]
Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D
J Mol Cell Cardiol. 2007 Apr;42(4):835-41. Epub 2007 Jan 24
DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo [PubMed]
Bright R, Steinberg GK, Mochly-Rosen D
Brain Res. 2007 May 4;1144:146-55. Epub 2007 Feb 2
Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage [PubMed]
Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D
Cardiovasc Res. 2007 Mar 1;73(4):699-709. Epub 2006 Dec 13
Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces [PubMed]
Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D
J Biol Chem. 2007 Feb 9;282(6):4113-23. Epub 2006 Dec 2
RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function [PubMed]
Vallentin A, Mochly-Rosen D
J Biol Chem. 2007 Jan 19;282(3):1650-7. Epub 2006 Nov 22
2006
Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells [PubMed]
Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA
Biochem Biophys Res Commun. 2007 Jan 12;352(2):423-30. Epub 2006 Nov 15
Protein kinase C delta (deltaPKC)-annexin V interaction: a required step in deltaPKC translocation and function [PubMed]
Kheifets V, Bright R, Inagaki K, Schechtman D, Mochly-Rosen D
J Biol Chem. 2006 Aug 11;281(32):23218-26. Epub 2006 Jun 18
Epsilon protein kinase C as a potential therapeutic target for the ischemic heart [PubMed]
Inagaki K, Churchill E, Mochly-Rosen D
Cardiovasc Res. 2006 May 1;70(2):222-30. Epub 2006 Feb 23
2005
The role of protein kinase C in cerebral ischemic and reperfusion injury [PubMed]
Bright R, Mochly-Rosen D
Stroke. 2005 Dec;36(12):2781-90. Epub 2005 Oct 27
RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death [PubMed]
Szabo G, Hoek JB, Darley-Usmar V, Hajnoczky G, Knudsen T, Mochly-Rosen D, Zakhari S
Alcohol Clin Exp Res. 2005 Sep;29(9):1749-52
PKC-{epsilon}-dependent survival signals in diabetic hearts [PubMed]
Malhotra A, Begley R, Kang BP, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG
Am J Physiol Heart Circ Physiol. 2005 Oct;289(4):H1343-50. Epub 2005 May 13
Ethanol withdrawal-associated allodynia and hyperalgesia: age-dependent regulation by protein kinase C epsilon and gamma isoenzymes [PubMed]
Shumilla JA, Liron T, Mochly-Rosen D, Kendig JJ, Sweitzer SM
J Pain. 2005 Aug;6(8):535-49
DeltaPKC-mediated activation of epsilonPKC in ethanol-induced cardiac protection from ischemia [PubMed]
Inagaki K, Mochly-Rosen D
J Mol Cell Cardiol. 2005 Aug;39(2):203-11
Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation [PubMed]
Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI
Circ Res. 2005 Jul 8;97(1):78-85. Epub 2005 Jun 16
Protein kinase C delta cleavage initiates an aberrant signal transduction pathway after cardiac arrest and oxygen glucose deprivation [PubMed]
Raval AP, Dave KR, Prado R, Katz LM, Busto R, Sick TJ, Ginsberg MD, Mochly-Rosen D, Pérez-Pinzón MA
J Cereb Blood Flow Metab. 2005 Jun;25(6):730-41
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators [PubMed]
Tanaka M, Gunawan F, Terry RD, Inagaki K, Caffarelli AD, Hoyt G, Tsao PS, Mochly-Rosen D, Robbins RC
J Thorac Cardiovasc Surg. 2005 May;129(5):1160-7
Protein kinase Cgamma mediates ethanol withdrawal hyper-responsiveness of NMDA receptor currents in spinal cord motor neurons [PubMed]
Li HF, Mochly-Rosen D, Kendig JJ
Br J Pharmacol. 2005 Feb;144(3):301-7
Cardioprotection by epsilon-protein kinase C activation from ischemia: continuous delivery and antiarrhythmic effect of an epsilon-protein kinase C-activating peptide [PubMed]
Inagaki K, Begley R, Ikeno F, Mochly-Rosen D
Circulation. 2005 Jan 4;111(1):44-50. Epub 2004 Dec 20
2004
Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria [PubMed]
Murriel CL, Churchill E, Inagaki K, Szweda LI, Mochly-Rosen D
J Biol Chem. 2004 Nov 12;279(46):47985-91. Epub 2004 Aug 31
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts [PubMed]
Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
Circulation. 2004 Sep 14;110(11 Suppl 1):II194-9
Protein kinase C delta mediates cerebral reperfusion injury in vivo [PubMed]
Bright R, Raval AP, Dembner JM, Pérez-Pinzón MA, Steinberg GK, Yenari MA, Mochly-Rosen D
J Neurosci. 2004 Aug 4;24(31):6880-8
Exaggerated nociceptive responses on morphine withdrawal: roles of protein kinase C epsilon and gamma [PubMed]
Sweitzer SM, Wong SM, Tjolsen A, Allen CP, Mochly-Rosen D, Kendig JJ
Pain. 2004 Jul;110(1-2):281-9
RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling [PubMed]
Miller LD, Lee KC, Mochly-Rosen D, Cartwright CA
Oncogene. 2004 Jul 22;23(33):5682-6
Epsilon protein kinase C mediated ischemic tolerance requires activation of the extracellular regulated kinase pathway in the organotypic hippocampal slice [PubMed]
Lange-Asschenfeldt C, Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA
J Cereb Blood Flow Metab. 2004 Jun;24(6):636-45
Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injury [PubMed]
Wang J, Bright R, Mochly-Rosen D, Giffard RG
Neuropharmacology. 2004 Jul;47(1):136-45
Biodistribution of intracellularly acting peptides conjugated reversibly to Tat [PubMed]
Begley R, Liron T, Baryza J, Mochly-Rosen D
Biochem Biophys Res Commun. 2004 Jun 11;318(4):949-54
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats [PubMed]
Sweitzer SM, Wong SM, Peters MC, Mochly-Rosen D, Yeomans DC, Kendig JJ
J Pharmacol Exp Ther. 2004 May;309(2):616-25. Epub 2004 Feb 4
State-specific monoclonal antibodies identify an intermediate state in epsilon protein kinase C activation [PubMed]
Souroujon MC, Yao L, Chen H, Endemann G, Khaner H, Geeraert V, Schechtman D, Gordon AS, Diamond I, Mochly-Rosen D
J Biol Chem. 2004 Apr 23;279(17):17617-24. Epub 2004 Feb 3
A critical intramolecular interaction for protein kinase Cepsilon translocation [PubMed]
Schechtman D, Craske ML, Kheifets V, Meyer T, Schechtman J, Mochly-Rosen D
J Biol Chem. 2004 Apr 16;279(16):15831-40. Epub 2004 Jan 22
Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon [PubMed]
Gray MO, Zhou HZ, Schafhalter-Zoppoth I, Zhu P, Mochly-Rosen D, Messing RO
J Biol Chem. 2004 Jan 30;279(5):3596-604. Epub 2003 Nov 4
2003
Opposing roles of delta and epsilonPKC in cardiac ischemia and reperfusion: targeting the apoptotic machinery [PubMed]
Murriel CL, Mochly-Rosen D
Arch Biochem Biophys. 2003 Dec 15;420(2):246-54
Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo [PubMed]
Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D
Circulation. 2003 Nov 11;108(19):2304-7. Epub 2003 Nov 3
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator [PubMed]
Inagaki K, Hahn HS, Dorn GW 2nd, Mochly-Rosen D
Circulation. 2003 Aug 19;108(7):869-75. Epub 2003 Jul 14
Opposing effects of delta- and zeta-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors [PubMed]
Braun MU, Mochly-Rosen D
J Mol Cell Cardiol. 2003 Aug;35(8):895-903
Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta [PubMed]
Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J
J Neurochem. 2003 Jul;86(2):442-50
Methods for detecting binding proteins: an introduction [PubMed]
Endemann G, Mochly-Rosen D
Methods Mol Biol. 2003;233:307-25
Overlay method for detecting protein-protein interactions [PubMed]
Schechtman D, Murriel C, Bright R, Mochly-Rosen D
Methods Mol Biol. 2003;233:351-7
Glutathione S-transferase pull-down assay [PubMed]
Schechtman D, Mochly-Rosen D, Ron D
Methods Mol Biol. 2003;233:345-50
PKC isozyme selective regulation of cloned human cardiac delayed slow rectifier K current [PubMed]
Xiao GQ, Mochly-Rosen D, Boutjdir M
Biochem Biophys Res Commun. 2003 Jul 11;306(4):1019-25
Cytotoxicity of pEGFP vector is due to residues encoded by multiple cloning site [PubMed]
Endemann G, Schechtman D, Mochly-Rosen D
Anal Biochem. 2003 Feb 15;313(2):345-7
Epsilon PKC is required for the induction of tolerance by ischemic and NMDA-mediated preconditioning in the organotypic hippocampal slice [PubMed]
Raval AP, Dave KR, Mochly-Rosen D, Sick TJ, Pérez-Pinzón MA
J Neurosci. 2003 Jan 15;23(2):384-91
2002
The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins [PubMed]
Dell EJ, Connor J, Chen S, Stebbins EG, Skiba NP, Mochly-Rosen D, Hamm HE
J Biol Chem. 2002 Dec 20;277(51):49888-95. Epub 2002 Sep 30
Tissue angiotensin II during progression or ventricular hypertrophy to heart failure in hypertensive rats; differential effects on PKC epsilon and PKC beta [PubMed]
Inagaki K, Iwanaga Y, Sarai N, Onozawa Y, Takenaka H, Mochly-Rosen D, Kihara Y
J Mol Cell Cardiol. 2002 Oct;34(10):1377-85
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts [PubMed]
Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO
Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H1970-7
Isozyme-specific abnormalities of PKC in thyroid cancer: evidence for post-transcriptional changes in PKC epsilon [PubMed]
Knauf JA, Ward LS, Nikiforov YE, Nikiforova M, Puxeddu E, Medvedovic M, Liron T, Mochly-Rosen D, Fagin JA
J Clin Endocrinol Metab. 2002 May;87(5):2150-9
Sequential activation of individual PKC isozymes in integrin-mediated muscle cell spreading: a role for MARCKS in an integrin signaling pathway [PubMed]
Disatnik MH, Boutet SC, Lee CH, Mochly-Rosen D, Rando TA
J Cell Sci. 2002 May 15;115(Pt 10):2151-63
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta [PubMed]
Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI
Mol Biol Cell. 2002 Apr;13(4):1381-9
Molecular dynamics characterization of the C2 domain of protein kinase Cbeta [PubMed]
Banci L, Cavallaro G, Kheifets V, Mochly-Rosen D
J Biol Chem. 2002 Apr 12;277(15):12988-97. Epub 2002 Jan 8
Intracellular transport mechanisms of signal transducers [PubMed]
Dorn GW 2nd, Mochly-Rosen D
Annu Rev Physiol. 2002;64:407-29
2001
Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7) [PubMed]
Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D
Chem Biol. 2001 Dec;8(12):1123-9
Isozyme-specific inhibitors and activators of protein kinase C [PubMed]
Schechtman D, Mochly-Rosen D
Methods Enzymol. 2002;345:470-89
Adaptor proteins in protein kinase C-mediated signal transduction [PubMed]
Schechtman D, Mochly-Rosen D
Oncogene. 2001 Oct 1;20(44):6339-47
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Na(+) channels [PubMed]
Xiao GQ, Qu Y, Sun ZQ, Mochly-Rosen D, Boutjdir M
Am J Physiol Cell Physiol. 2001 Nov;281(5):C1477-86
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC [PubMed]
Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavallaro G, Banci L, Guo Y, Bolli R, Dorn GW 2nd, Mochly-Rosen D
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11114-9. Epub 2001 Sep 11
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C [PubMed]
Stebbins EG, Mochly-Rosen D
J Biol Chem. 2001 Aug 10;276(32):29644-50. Epub 2001 May 31
Localization, anchoring, and functions of protein kinase C isozymes in the heart [PubMed]
Mackay K, Mochly-Rosen D
J Mol Cell Cardiol. 2001 Jul;33(7):1301-7
Spontaneous occurrence of an inhibitor of protein kinase C localization in a thyroid cancer cell line: role in thyroid tumorigenesis [PubMed]
Mochly-Rosen D, Fagin JA, Knauf JA, Nikiforov Y, Liron T, Schechtman D
Adv Enzyme Regul. 2001;41:87-97
Arachidonic acid protects neonatal rat cardiac myocytes from ischaemic injury through epsilon protein kinase C [PubMed]
Mackay K, Mochly-Rosen D
Cardiovasc Res. 2001 Apr;50(1):65-74
Opposing effects of delta and xi PKC in ethanol-induced cardioprotection [PubMed]
Chen C, Mochly-Rosen D
J Mol Cell Cardiol. 2001 Mar;33(3):581-5
2000
Evidence for functional role of epsilonPKC isozyme in the regulation of cardiac Ca(2+) channels [PubMed]
Hu K, Mochly-Rosen D, Boutjdir M
Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H2658-64
Involvement of a p38 mitogen-activated protein kinase phosphatase in protecting neonatal rat cardiac myocytes from ischemia [PubMed]
Mackay K, Mochly-Rosen D
J Mol Cell Cardiol. 2000 Aug;32(8):1585-8
Protein kinase C isozymes and the regulation of diverse cell responses [PubMed]
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO
Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L429-38
Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation [PubMed]
Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW 2nd
Circ Res. 2000 Jun 9;86(11):1173-9
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C [PubMed]
Aley KO, Messing RO, Mochly-Rosen D, Levine JD
J Neurosci. 2000 Jun 15;20(12):4680-5
Pharmacological regulation of network kinetics by protein kinase C localization [PubMed]
Mochly-Rosen D, Kauvar LM
Semin Immunol. 2000 Feb;12(1):55-61
1999
Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C [PubMed]
Chen CH, Gray MO, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12784-9
Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation [PubMed]
Dorn GW 2nd, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12798-803
RACK1, a protein kinase C anchoring protein, coordinates the binding of activated protein kinase C and select pleckstrin homology domains in vitro [PubMed]
Rodriguez MM, Ron D, Touhara K, Chen CH, Mochly-Rosen D
Biochemistry. 1999 Oct 19;38(42):13787-94
Protein kinase C-epsilon is responsible for the protection of preconditioning in rabbit cardiomyocytes [PubMed]
Liu GS, Cohen MV, Mochly-Rosen D, Downey JM
J Mol Cell Cardiol. 1999 Oct;31(10):1937-48
Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis [PubMed]
Knauf JA, Elisei R, Mochly-Rosen D, Liron T, Chen XN, Gonsky R, Korenberg JR, Fagin JA
J Biol Chem. 1999 Aug 13;274(33):23414-25
Characterization of the binding and phosphorylation of cardiac calsequestrin by epsilon protein kinase C [PubMed]
Rodriguez MM, Chen CH, Smith BL, Mochly-Rosen D
FEBS Lett. 1999 Jul 9;454(3):240-6
Pharmacologic modulation of protein kinase C isozymes: the role of RACKs and subcellular localisation [PubMed]
Csukai M, Mochly-Rosen D
Pharmacol Res. 1999 Apr;39(4):253-9
An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia [PubMed]
Mackay K, Mochly-Rosen D
J Biol Chem. 1999 Mar 5;274(10):6272-9
1998
Peptide modulators of protein-protein interactions in intracellular signaling [PubMed]
Souroujon MC, Mochly-Rosen D
Nat Biotechnol. 1998 Oct;16(10):919-24
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis [PubMed]
Laudanna C, Mochly-Rosen D, Liron T, Constantin G, Butcher EC
J Biol Chem. 1998 Nov 13;273(46):30306-15
Molecular genetic approaches. II. Expression-interaction cloning [PubMed]
Csukai M, Mochly-Rosen D
Methods Mol Biol. 1998;88:133-9
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption [PubMed]
Miyamae M, Rodriguez MM, Camacho SA, Diamond I, Mochly-Rosen D, Figueredo VM
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8262-7
Modulating protein kinase C signal transduction [PubMed]
Mochly-Rosen D, Kauvar LM
Adv Pharmacol. 1998;44:91-145
Anchoring proteins for protein kinase C: a means for isozyme selectivity [PubMed]
Mochly-Rosen D, Gordon AS
FASEB J. 1998 Jan;12(1):35-42
A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death [PubMed]
Gray MO, Karliner JS, Mochly-Rosen D
J Biol Chem. 1997 Dec 5;272(49):30945-51
1997
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon [PubMed]
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D
J Biol Chem. 1997 Nov 14;272(46):29200-6
An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters [PubMed]
Hundle B, McMahon T, Dadgar J, Chen CH, Mochly-Rosen D, Messing RO
J Biol Chem. 1997 Jun 6;272(23):15028-35
C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels [PubMed]
Zhang ZH, Johnson JA, Chen L, El-Sherif N, Mochly-Rosen D, Boutjdir M
Circ Res. 1997 May;80(5):720-9
Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells [PubMed]
Yedovitzky M, Mochly-Rosen D, Johnson JA, Gray MO, Ron D, Abramovitch E, Cerasi E, Nesher R
J Biol Chem. 1997 Jan 17;272(3):1417-20
An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research [PubMed]
Johnson JA, Gray MO, Karliner JS, Chen CH, Mochly-Rosen D
Circ Res. 1996 Dec;79(6):1086-99
1996
Differential activation of protein kinase C isozymes by phorbol ester and collagen in human skin microvascular endothelial cells [PubMed]
Zhou LY, Disatnik M, Herron GS, Mochly-Rosen D, Karasek MA
J Invest Dermatol. 1996 Aug;107(2):248-52
A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function [PubMed]
Johnson JA, Gray MO, Chen CH, Mochly-Rosen D
J Biol Chem. 1996 Oct 4;271(40):24962-6
The HIV nef protein associates with protein kinase C theta [PubMed]
Smith BL, Krushelnycky BW, Mochly-Rosen D, Berg P
J Biol Chem. 1996 Jul 12;271(28):16753-7
Signal transduction by the polymeric immunoglobulin receptor suggests a role in regulation of receptor transcytosis [PubMed]
Cardone MH, Smith BL, Mennitt PA, Mochly-Rosen D, Silver RB, Mostov KE
J Cell Biol. 1996 Jun;133(5):997-1005
Stimulus-dependent subcellular localization of activated protein kinase C; a study with acidic fibroblast growth factor and transforming growth factor-beta 1 in cardiac myocytes [PubMed]
Disatnik MH, Jones SN, Mochly-Rosen D
J Mol Cell Cardiol. 1995 Nov;27(11):2473-81
Interaction of protein kinase C with RACK1, a receptor for activated C-kinase: a role in beta protein kinase C mediated signal transduction [PubMed]
Mochly-Rosen D, Smith BL, Chen CH, Disatnik MH, Ron D
Biochem Soc Trans. 1995 Aug;23(3):596-600
1995
C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo [PubMed]
Ron D, Luo J, Mochly-Rosen D
J Biol Chem. 1995 Oct 13;270(41):24180-7
Prolonged phorbol ester treatment down-regulates protein kinase C isozymes and increases contraction rate in neonatal cardiac myocytes [PubMed]
Johnson JA, Adak S, Mochly-Rosen D
Life Sci. 1995;57(11):1027-38
The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor [PubMed]
Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7824-8
Localization of protein kinases by anchoring proteins: a theme in signal transduction [PubMed]
Mochly-Rosen D
Science. 1995 Apr 14;268(5208):247-51
Inhibition of the spontaneous rate of contraction of neonatal cardiac myocytes by protein kinase C isozymes. A putative role for the epsilon isozyme [PubMed]
Johnson JA, Mochly-Rosen D
Circ Res. 1995 Apr;76(4):654-63
An autoregulatory region in protein kinase C: the pseudoanchoring site [PubMed]
Ron D, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):492-6
Distinct responses of protein kinase C isozymes to c-erbB-2 activation in SKBR-3 human breast carcinoma cells [PubMed]
Disatnik MH, Winnier AR, Mochly-Rosen D, Arteaga CL
Cell Growth Differ. 1994 Aug;5(8):873-80
1994
Developmental expression of protein kinase C subspecies in rat brain-pituitary axis [PubMed]
Garcia-Navarro S, Marantz Y, Eyal R, Kalina M, Disatnik MH, Mochly-Rosen D, Ben-Menahem D, Reiss N, Naor Z
Mol Cell Endocrinol. 1994 Jul;103(1-2):133-8
Agonists and antagonists of protein kinase C function, derived from its binding proteins [PubMed]
Ron D, Mochly-Rosen D
J Biol Chem. 1994 Aug 26;269(34):21395-8
Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells [PubMed]
Cardone MH, Smith BL, Song W, Mochly-Rosen D, Mostov KE
J Cell Biol. 1994 Mar;124(5):717-27
Localization of protein kinase C isozymes in cardiac myocytes [PubMed]
Disatnik MH, Buraggi G, Mochly-Rosen D
Exp Cell Res. 1994 Feb;210(2):287-97
Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins [PubMed]
Ron D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):839-43
Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C [PubMed]
Disatnik MH, Hernandez-Sotomayor SM, Jones G, Carpenter G, Mochly-Rosen D
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):559-63
1992
Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme [PubMed]
Smith BL, Mochly-Rosen D
Biochem Biophys Res Commun. 1992 Nov 16;188(3):1235-40
Nicotinic acetylcholine receptor desensitization is regulated by activation-induced extracellular adenosine accumulation [PubMed]
Pitchford S, Day JW, Gordon A, Mochly-Rosen D
J Neurosci. 1992 Nov;12(11):4540-4
p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C [PubMed]
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J, Smith BL
Biochemistry. 1992 Sep 8;31(35):8120-4
1991
Intracellular receptors for activated protein kinase C. Identification of a binding site for the enzyme [PubMed]
Mochly-Rosen D, Khaner H, Lopez J, Smith BL
J Biol Chem. 1991 Aug 15;266(23):14866-8
The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae [PubMed]
Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E
Proc Biol Sci. 1991 Feb 22;243(1307):165-71
The role of adenosine and adenosine transport in ethanol-induced cellular tolerance and dependence. Possible biologic and genetic markers of alcoholism [PubMed]
Diamond I, Nagy L, Mochly-Rosen D, Gordon A
Ann N Y Acad Sci. 1991;625:473-87
Identification of intracellular receptor proteins for activated protein kinase C [PubMed]
Mochly-Rosen D, Khaner H, Lopez J
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3997-4000
A protein kinase C isozyme is translocated to cytoskeletal elements on activation [PubMed]
Mochly-Rosen D, Henrich CJ, Cheever L, Khaner H, Simpson PC
Cell Regul. 1990 Aug;1(9):693-706
GTP-binding proteins are restricted to signal transduction sites [PubMed]
Mochly-Rosen D, Gordon AS
Biochem Biophys Res Commun. 1990 Nov 30;173(1):388-95
Chronic ethanol-induced heterologous desensitization is mediated by changes in adenosine transport [PubMed]
Gordon AS, Nagy L, Mochly-Rosen D, Diamond I
Biochem Soc Symp. 1990;56:117-36
1988
Chronic ethanol causes heterologous desensitization of receptors by reducing alpha s messenger RNA [PubMed]
Mochly-Rosen D, Chang FH, Cheever L, Kim M, Diamond I, Gordon AS
Nature. 1988 Jun 30;333(6176):848-50
A general procedure for screening inhibitory antibodies: application for identifying anti-protein kinase C antibodies [PubMed]
Mochly-Rosen D, Koshland DE Jr
Anal Biochem. 1988 Apr;170(1):31-7
1987
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C [PubMed]
Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE Jr, Cole RD
Biochemistry. 1987 May 19;26(10):2886-93
Distinct cellular and regional localization of immunoreactive protein kinase C in rat brain [PubMed]
Mochly-Rosen D, Basbaum AI, Koshland DE Jr
Proc Natl Acad Sci U S A. 1987 Jul;84(13):4660-4
Exposure of HeLa DNA polymerase alpha to protein kinase C affects its catalytic properties [PubMed]
Krauss SW, Mochly-Rosen D, Koshland DE Jr, Linn S
J Biol Chem. 1987 Mar 15;262(8):3432-5
Domain structure and phosphorylation of protein kinase C [PubMed]
Mochly-Rosen D, Koshland DE Jr
J Biol Chem. 1987 Feb 15;262(5):2291-7
1986
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity [PubMed]
Bollag GE, Roth RA, Beaudoin J, Mochly-Rosen D, Koshland DE Jr
Proc Natl Acad Sci U S A. 1986 Aug;83(16):5822-4
1985
Antigenic specificity of acetylcholine receptor in developing muscle. Studies with monoclonal antibodies [PubMed]
Souroujon MC, Pizzighella S, Mochly-Rosen D, Fuchs S
J Neuroimmunol. 1985 May;8(2-3):159-66
1984
Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs [PubMed]
Goldberg G, Mochly-Rosen D, Fuchs S, Lass Y
J Membr Biol. 1983;76(2):123-8
1983
An anti-acetylcholine receptor monoclonal antibody cross-reacts with phosvitin [PubMed]
Pizzighella S, Gordon AS, Souroujon MC, Mochly-Rosen D, Sharp A, Fuchs S
FEBS Lett. 1983 Aug 8;159(1-2):246-50
Interaction of monoclonal antibodies to Torpedo acetylcholine receptor with the receptor of skeletal muscle [PubMed]
Souroujon MC, Mochly-Rosen D, Gordon AS, Fuchs S
Muscle Nerve. 1983 May;6(4):303-11
1982
Acetylcholine receptor: molecular dissection and monoclonal antibodies in the study of experimental myasthenia [PubMed]
Fuchs S, Bartfeld D, Mochly-Rosen D, Souroujon M, Feingold C
Ann N Y Acad Sci. 1981;377:110-24
Molecular aspects of experimental autoimmune myasthenia gravis [PubMed]
Fuchs S, Bartfeld D, Mochly-Rosen D, Schmidt-Hopfeld I, Tarrab-Hazdai R
Prog Clin Biol Res. 1981;63:405-17
Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site [PubMed]
Mochly-Rosen D, Fuchs S
Biochemistry. 1981 Sep 29;20(20):5920-4
1980
Modification of acetylcholine receptor: chemical and immunological characterization of polyalanyl acetylcholine receptor [PubMed]
Tarrab-Hazdai R, Schmidt-Sole Y, Mochly-Rosen D, Fuchs S
FEBS Lett. 1980 Aug 25;118(1):35-8
Immune regulation of experimental myasthenia [PubMed]
Fuchs S, Bartfeld D, Eshhar Z, Feingold C, Mochly-Rosen D, Novick D, Schwartz M, Tarrab-Hazdai R
J Neurol Neurosurg Psychiatry. 1980 Jul;43(7):634-43
PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting [PubMed]
Monti M, Donnini S, Morbidelli L, Giachetti A, Mochly-Rosen D, Mignatti P, Ziche M
J Mol Cell Cardiol. 2013 Oct;63:107-17. doi: 10.1016/j.yjmcc.2013.07.006. Epub 2013 Jul 20