Che-Hong Chen, Ph.D.
My research focus is in the area of cardioprotection against ischemia using a variety of animal models. In particular, I am studying the effects of moderate consumption of ethanol in this process. I am also identifying the signaling pathways down-stream of protein kinase C that are activated in the process of an ischemic event and following exposure to ethanol.
My name is Marie-Helene Disatnik. I grew up in France then move to Israel for my undergraduate and graduate studies. I joined Daria Mochly-Rosen’s lab for a postdoc fellowship in 1991. After spending few years at UCSF and Stanford as a senior scientist, I came back two years ago to Daria’s lab to characterize a new generation of peptides derived from the C2 domain of ε and δPKC that might modulate PKC activity by interfering with critical protein-protein interactions within/between PKC and PKC-binding proteins. Characterizing protein–protein interaction surfaces helps further our understanding of key events in cell signaling.
I graduated from Stanford in 2003 and completed my undergraduate
honors thesis work in the Mochly-Rosen lab. I have returned as a Life
Science Research Associate and am studying the role of PKC and its
downstream targets in alcohol metabolism and nuerodegenerative
Grant Budas completed his PhD in cell physiology at the University of Dundee, UK before joining the Mochly-Rosen lab in 2006. Grant’s research is focused on the role of protein kinase C epsilon (εPKC) and aldehyde dehydrogenase 2 (ALDH2) in myocardial ischemia and other oxidative-stress related diseases. Grant is also designing peptide regulators of intra and inter-molecular protein-protein interactions. Grant is the recipient of a postdoctoral fellowship from the American Heart Association.
Nir Qvit, Ph.D.
I am trying to understand the role of delta PKC in the regulation of mitochondrial function during cardiac ischemia and reperfusion. This includes identifying mitochondrial proteins that may be targets of delta PKC, the role of delta PKC in mitochondrial metabolism and trying to understand the relationship of delta PKC and reactive oxygen species generated during reperfusion. All of this will help ellucidate the mechanism of reperfusion mediated cardiac dysfunction.
Suresh Palaniyandi, Ph.D.
Hi, I’m Suresh Palaniyandi Selvaraj. Basically, I am from Tamil Nadu, India. I have joined as a postdoc scholar in Mochly Rosen’s lab on Sep-2006. Currently I am investigating the role of protein kinase C (PKC) signaling in mast cell activity and its implication in the pathogenesis of heart failure. In another project, I am checking the role of PKC beta II signaling in angiotensin-II mediated cardiac hypertrophy.
Xin Qi, Ph.D.
I am a postdoctoral fellow. I obtained my Ph.D. from Japan and M.S. from China. My current research focuses on identification of molecular signaling pathway related to PKC in stroke and hypertension.
Gouri Yogalingam Ph.D.
I joined Daria's lab in 2009. I am a cell biologist with an interest in how lysosomes contribute to normal cellular function as well as the pathogenesis of complex diseases of the heart, brain and lung. Here at Stanford in Daira's lab, I have optimized a cell-based model for ischemia-reperfusion injury, a type of injury that occurs in cardiomyocytes during myocardial infarction. I am using this model to study how protein kinase c contributes to cell death in cardiomyocytes. At Duke University in Ann Marie Pendergast's lab I focussed on the role of Abl kinase signaling in the autophagic degradation of cytosolic proteins in lung cancer cells. At St Jude Children's Research Hospital, in Sandra d'Azzo's lab, I worked on understanding why, in some instances, lysosomes dock at the plasma membrane and release their contents extracellularly. I did my PhD training in Adelaide, South Australia, working on the mutations that cause lysosomal storage disease.
I received my B.S. degree in 2005 from Yale University, where I majored in Molecular, Cellular and Developmental Biology. I decided to go straight to graduate school because of my perpetual rapport with science. I am currently a 4th-year Ph.D. student in the Department of Chemical and Systems Biology. My project focuses on the role of epsilon PKC in cardiac fibrosis in the development of heart failure. I wish to determine whether epsilon PKC regulates the molecular and cellular processes involved in cardiac fibrosis, such as fibroblast migration, differentiation, and extracellular matrix (ECM) remodeling. I am particularly interested in the function of epsilon PKC in histone deacetylase-mediated transcriptions of matrix metalloproteinases (MMPs), which are central players in the ECM remodeling during fibrosis. This may help define a novel role for epsilon PKC in transcriptional machinery and nuclear organization.