Meyer Lab

97.Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 2009 Jul 31;35(2):229-39.

96. Hahn AT, Jones JT, Meyer T. Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle. 2009 Apr 1;8(7):1044-52.

95. Collins SR, Meyer T. Calcium flickers lighting the way in chemotaxis. Dev. Cell. 2009 Feb;16(2):160-1.

94. Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devrotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and sctivity of the tumor suppressor PTEN. Proc Natl Acad Sci USA. 2009 Jan 13;106(2):480-5.

93.Vitorino P, Meyer T. Modular control of endothelial sheet migration. Genes Dev. 2008 Dec 1;22(23):3268-81.

92. Brandman O, Meyer T. Feedback loops shape cellular signals in space and time. Science. 2008 Oct 17;322(5900):390-5.

91. Inoue T, Meyer T. Synthetic activation of endogenous PI3K and Rac identifies and AND-gate switch for cell polarization and migration. PLoS ONE. 2008 Aug 27;3(8):e3068.

90. Kaplan DD, Zimmermann G, Suyama K, Meyer T, Scott MP. A nucleostemin family GTPas, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev. 2008 Jul 15;22(14):1877-93.

89. Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, T. Meyer, Suh PG, Ryu SH.
Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane.
Mol Biol Cell. 2008

88. Park WS, Heo WD, Whalen JH, O'Rourke NA, Bryan HM, T. Meyer, Teruel MN.
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.
Mol Cell. 2008 May 9;30(3):381-92.

87. Abe N, Inoue T, Galvez T, Klein L, Meyer T. Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci. 2008 May 1;121(Pt 9):1488-94.

86. Guignet EG, Meyer T. Suspended-drop Electroporation for high-throughput delivery of biomolecues into cells. Nat Methods. 2008 May; 5(5):393-5.

85. Fivaz M, Bandara S, Inoue T, T. Meyer. 2008. Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Current Biology. Jan 8; 18(1):44-50.

84. Brandman O, Liou J, Park WS, T. Meyer. 2007. STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca(2+) Levels. Cell. Dec 28; 131(7):1327-29.

83. Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells. Cell Cycle. 2007 July;6(18):2276-83.

82. Galvez, T., Teruel, M.N., Heo, WD, Jones, J.T., Kim, M.L., Liou, J., Myers, J.W., T. Meyer. 2007. siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol. Jul 19;8(7):R142

81. Liou, J., Fivaz, M., Inoue, T., and T. Meyer. 2007. Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A. May 29;104(22):9301-6.

80. Aoki, K., Nakamura, T., Inoue, T., Meyer, T., and M. Matsuda. 2007. An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol. Jun 4;177(5):817-27.

79. Stone, M., Jia, S., Heo, W.D., Meyer, T., and K.V. Konan. 2007. Participation of Rab5, an Early Endosome Protein, in Hepatitis C Virus RNA Replication Machinery. Journal of Virology. Feb 4; 81: 4551-63.

78. Smith, A.C., Heo, W.D., Braun, V., Jiang, X., Macrae, C., Casanova, J.E., Scidmore, M.A., Grinstein, S., Meyer, T., and J.H. Brumell. 2007. A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.
J. Cell Biol. Jan 29;176(3):263-8.

77. Gong, D., Pomerening, J.R., Myers, J.W., Gustavsson, C., Jones, J.T., Hahn, A.T., Meyer, T., and J.E. Ferrell. 2007. Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol. Jan 9;17(1):85-91.

76. Zavzavadjian, J.R., Couture, S., Sun Park, W., Whalen, J., Lyon, S., Lee, G., Fung, E., Mi, Q., Liu, J., Wall, E., Santat, L., Dhandapani, K., Kivork, C., Driver, A., Zhu, X., Sook Chang, M., Randhawa, B., Gehrig, E., Bryan, H., Verghese, M., Maer, A., Saunders, B., Ning, Y., Subramaniam, S., Meyer, T., Simon, M.I., O'rourke, N., Chandy, G., and I.D. Fraser. 2007. The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis.
Mol Cell Proteomics. 2007 Jan 5;

75. Heo, W.D., Inoue, T., Park, W.S., Kim, M.L., Park, B.O., Wandless, T.J., and T. Meyer. 2006. PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science. 314(5804):1458-61.

74. Suh, B.C., Inoue, T., Meyer, T., and B. Hille. 2006. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science. 314(5804):1454-7.

73. Brandman, O., Ferrell, J.E. Jr, Li, R., and T. Meyer. 2005. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310(5747):496-8.

72. Craske, M.L., Fivaz, M., Batada, N.N., and T. Meyer. 2005. Spines and neurite branches function as geometric attractors that enhance protein kinase C action. J Cell Biol. 170(7):1147-58.

71. Fivaz, M. and T. Meyer. 2005. Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin. J Cell Biol. 170(3):429-41.

70. Liou, J., Kim, M.L., Heo, W.D., Jones, J.T., Myers, J.W., Ferrell, J.E. Jr, and T. Meyer. 2005. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr Biol. 15(13):1235-41.

69. Inoue, T., Heo, W.D., Grimley, J.S., Wandless, T.J.,and T. Meyer. 2005. An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods. 2(6):415-8.

68. Wollman, R., Cytrynbaum, E.N., Jones, J.T., Meyer, T, Scholey, J.M., and A. Mogilner. 2005. Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly. Curr Biol. 15(9):828-32.

67. Arrieumerlou, C. and T. Meyer. 2005. A Local Coupling Model and Compass Parameter for Eukaryotic Chemotaxis. Developmental Cell vol. 8: 215-227.

66. O'rourke, N.A., Meyer, T., G. and Chandy. 2005. Protein localization studies in the age of 'Omics'. Curr Opin Chem Biol. 9(1):82-7.

65. Baryza, J.L., Brenner, S.E., Craske, M.L., Meyer, T., and P.A. Wender. 2004. Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP. Chem Biol. 11(9):1261-7.

64. Eom, C.Y., Heo, W.D., Craske, M.L., Meyer, T., and L.R. Lehman. 2004. The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection. Proc Natl Acad Sci U S A. 101(12):4036-40.

63. Jones, J.T., Myers, J.W., Ferrell, J.E., and Meyer, T. 2004. Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol. (3):306-12.

62. Schechtman, D., Craske, M.L., Kheifets, V., Meyer, T., Schechtman, J., and Mochly-Rosen, D. 2004. A critical intramolecular interaction for protein kinase Cepsilon translocation. J. Biol Chem 279(16):15831-40.

61. Fivaz, M., and Meyer, T. 2003 Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron. 40(2):319-30.

60. Bradshaw, J.M., Kubota, Y., Meyer, T., and H. Schulman. 2003. An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proc. Natl. Acad. Sci. USA 100(18):10512-7.

59. Fink, C.C., Bayer, K.U., Ferrell, J.E. Jr., Schulman, H. and T. Meyer. 2003. Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII. Neuron 39(2):283-97.

58. Heo, W.D. and T. Meyer. 2003. Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases. Cell 113(3):315-28.

57. Myers, J.W., Jones, J.T., Meyer, T., and J.E. Ferrell. 2003. Recombinant Dicer efficiently converts large dsRNAs into siRNAs suitable for gene silencing. Nat Biotechnol. 21(3):324-8.

56. Meyer, T. and M.N. Teruel. 2003. Fluorescence imaging of signaling networks. Trends Cell Biol. 13(2):101-6.

55. Tengholm, A., Teruel, M.N., and T. Meyer. 2003. Single cell imaging of PI3K activity and glucose transporter insertion into the plasma membrane by dual color evanescent wave microscopy. Sci STKE 2003(169):PL4.

54. Tengholm A. and T. Meyer. 2002. A PI3-Kinase Signaling Code for Insulin-Triggered Insertion of Glucose Transporters into the Plasma Membrane. Current Biology 12: 1871-1876.

53. Fink C.C. and T. Meyer. 2002. Molecular mechanisms of CaMKII activation in neuronal plasticity. Curr. Opin. Neurobiol. 12(3): 293-9.

52. Haugh JM and Meyer, T. 2002. Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling. J Cell Sci 115: 303-10.

51. Teruel, M.N. and T. Meyer. 2002. Parallel Single Cell Monitoring of Receptor-Triggered Membrane Translocation of a Calcium Sensing Protein Module. Science 295:1910-2.

50. Marshall, J.G., J.W. Booth, V. Stambolic, T. Mak, T. Balla, A.D. Schreiber, T. Meyer, and S. Grinstein. 2001. Restricted accumulation of phosphatidylinositol 3-kinase products in a plamalemmal subdomain during Fc gamma receptor-mediated phagocytosis. J. Cell Biology 153(7): 1369-80.

49. Codazzi, F., Teruel, M.N., and T. Meyer. 2001. Control of Astrocyte Ca2+ Oscillations and Waves by Oscillating Translocation and Activation of Protein Kinase C. Current Biology 11(14): 1089-97.

48. Hurley, J.H. and Meyer, T. 2001. Subcellular targeting by membrane lipids. Curr. Opin. Cell Biol. 13:146-52.

47. Botelho, R.J., Teruel, M.N., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., and Gringstein, S. 2000. Localized Biphasic Chanes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis. J. Cell Biology 151: 1353-1368.

46. Haugh, J.M., Codazzi, F., Teruel, M.N., and T. Meyer. 2000. Spatial Sensing in Fibroblasts Mediated by 3'Phosphoinositides. J. Cell Biology 151: 1269-1280.

45. Teruel, M.N. and T. Meyer. 2000. Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction. Cell 103:181-4.

44. Meyer, T. and Oancea, E. 2000. Studies of signal transduction events using chimeras to green fluorescent protein. Methods in Enzymology 327:500-13.

43. Shen, K., M. N. Teruel, J. H. Connor, S. Shenolikar, and T. Meyer. 2000. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nature Neuroscience 3: 881-6.

42. Meyer, T. and Shen, K. 2000. In and out of the postsynaptic region: signalling proteins on the move. Trends in Cell Biology 10: 238-44.

41. Raucher, D., Stauffer, T., Chen, W., Shen, K., Guo, S., York, J.D., Sheetz, M.P., and T. Meyer. 2000. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell 100:221-8.

40. Teruel, M.N., Chen, W., Persechini, A. and T. Meyer. 2000. Differential codes for free Ca2+-calmodulin in nucleus and cytosol. Current Biology 10:86-94.

39. Teruel, M.N., Blanpied, T.A., Shen, K., Augustine, G.J., and Meyer, T. 1999. A versatile microporation technique for the transfection of cultured CNS neurons. J. Neuroscience Methods 93: 37-48.

38. Shen, K. and T. Meyer. 1999. Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA-receptor Stimulation. Science 284:162-6.

37. Improta-Brears, T., Whorton, A.R., Codazzi, F., York, J.D., Meyer, T., and D.P. McDonnell. 1999. Estrogen-Induced Activation of MapK Requires Mobilization of Intracellular Calcium. Proc. Nat. Acad. Science 96:4686-91.

36. Oancea, E. and T. Meyer. 1998. Protein Kinase C as a Molecular Machine for Decoding Calcium and Diacylglycerol Signals. Cell 95:307-18.

35. Shen, K., Teruel. M.N.,Subramanian, K., and T. Meyer. 1998. CaMKIIb functions as an F-actin targeting module that localizes CaMKIIa/b hetero-oligomers to dendritic spines. Neuron 21: 593-606.

34. Kontos, C.D., Stauffer, T.P., Yang W-P., Huang, L., Blanar, M.A., Meyer, T., and K.G. Peters. 1998. Activation of Phosphatidylinositol 3-Kinase and Akt by Tie1:A potential role for Tie2 in endothelial cell survivial. Mol. Cell Biology 18: 4131-4140.

33. Feng, X., Zhang, J., Barak, L.S., Meyer, T., Caron, M.G., and Hannun, Y.A. 1998. Visualization of Dynamic Trafficking of a Protein Kinase C betaII/Green Fluorescent Protein Conjugate Reveals Differences in G Protein-coupled Receptor Activation and Desensitization. J Biol Chem 273:10755-10762.

32. Stauffer, T.P., Ahn, S. and T. Meyer. 1998. Receptor-induced Transient Reduction in Plasma Membrane Phosphatidylinositol-4,5 Biphosphate Concentration Monitored in Living Cells. Current Biology 8:343-346.

31. Horne, J.H. and Meyer, T. 1998. Characterization of a Dextran-Based Bifunctional Calcium Indicator Immobilized in Cells by the Enzymatic Addition of Isoprenoid Lipids. Cell Calcium 25:1-7 .

30. Oancea, E., Teruel, M.N., Quest, A.F.G., and Meyer, T. 1998. GFP-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. J.Cell Biol. 140:1-14.

29. Shen, K. and Meyer, T. 1998. Oligomerization of Ca2+/Calmodulin Dependent Protein Kinase IIa: Domain Requirement and In Vivo Mobility of Oligomer. J. Neurochemistry 70:96-104.

28. Stauffer, T.P. and Meyer, T. 1997. Compartmentalized Receptor-Mediated Tyrosine Phosphorylation in Living Cells. J.Cell Biol.139:1447-1454.

27. Thissen, J. A., Gross, J., Subramanian, K., Meyer, T., and Casey P. J. 1997. Prenylation-dependent association of K-Ras with microtubules: Evidence for a role in trafficking to plasma membrane. J.Biol.Chem.272:30362-30370.

26. Stauffer, T. P., Martenson, C. H., Rider, J. E., Kay, B. K., and Meyer, T. 1997. Inhibition of Lyn Function in Mast Cell Activation by SH3 Domain Binding Peptides. Biochemistry 36:9388-9394 .

25. Teruel, M.N. and Meyer, T. 1997. Electroporation Induced Formation of Individual Calcium Entry Sites in Cell Body and Processes of Adherent Cells. Biophys. J. 73:1785-1796.

24. Horne, J.H. and Meyer, T. 1997. Elementary Calcium Release Units Induced by Inositol Trisphosphate. Science 273: 1690-1693.

23. Subramanian, K. and Meyer, T. 1997. Calcium-Induced Changes in the Structure of Endoplasmic Reticulum and Nuclear Envelope Calcium Stores. Cell 89:963-971.

22. Jacobs, J. M. and Meyer, T. 1997. Control of Action Potential-Induced Ca2+ Signaling in the Soma of Hippocampal Neurons by Ca2+ Release from Intracellular Stores. J. Neuroscience 17:4129-4135.

21. Barak, L.S., Ferguson, S. G., Zhang, J., Martenson, C., Meyer, T., and Caron, M. G. 1996. Internal Trafficking and Surface Mobility of a Functionally Intact b2Adrenergic Receptor-Green Fluorescent Protein Conjugate. Molecular Pharmacology 51: 171-184.

20. Yokoe, H. and Meyer, T. 1996. Spatial Dynamics of GFP-Tagged Proteins Investigated by Local Fluorescence Enhancement. Nature Biotechnology 14:1252-1256

19. Oancea, E. and Meyer, T. 1996. Reversible Desensitization of Inositol Trisphosphate Induced Calcium Release Provides a Mechanism for Repetitive Calcium Spikes. J.Biol.Chem.271:17253-17260.

18. Horne, J.H. and Meyer, T. 1995. Luminal Calcium Regulates the Inositol 1,4,5-Trisphosphate Receptor at a Cytosolic Site. Biochemistry 34: 12738-12746.

17. Reinhard, E., Yokoe, H., Niebling, K., Allbritton, N. L., Kuhn, M. and Meyer, T. 1995. Localized Calcium Signals During Early Zebrafish Development.Developmental Biology 170: 50-61.

16. Meyer, T., Oancea, E. and Allbritton, N. L. 1995. Nuclear Calcium Signals. Ciba Foundation Symposium 188: "Calcium waves, gradients and oscillations." Wiley, Chichester. p 252-266.

15. Allbritton, N. L., Oancea, E., Kuhn, M. and Meyer, T. 1994. Source of Nuclear Calcium Signals. Proc. Natl. Acad. Sci. USA 91: 12458-12462.

14. Hanson, P., I., Meyer, T., Stryer, L. and Schulman, H. 1994. Dual Role of Calmodulin in Autophosphorylation of Multifunctional CaM Kinase May Underlie Decoding of Calcium Signals. Neuron 12: 943-956.

13. Allbritton, N. L. and Meyer, T. 1993. Localized Calcium Spikes and Propagating Calcium Waves. Cell Calcium 14: 691-697.

12. Kindman, A. and Meyer, T. 1993. Use of Intracellular Ca2+ Stores from Rat Basophilic Leukemia Cells To Study the Molecular Mechanism Leading to Quantal Ca2+ Release by Inositol 1,4,5-Trisphosphate. Biochemistry 32: 1270-1277.

11. Meyer, T., Hansen, P., Stryer, L. and Schulman. H., 1992. Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase. Science 256: 1199-1202.

10. Allbritton, N., Meyer, T. and Stryer, L., 1992. Range of Messenger Action of Calcium and Inositol 1,4,5-trisphosphate. Science 258:1812-1815.

9. Schulman, H., Hanson, P. and Meyer, T., 1992. Decoding Calcium Signals by Multifunctional CaM Kinase. Cell Calcium 13: 401-411.

8. Spudich, A., Meyer, T. and Stryer, L., 1992. Association of the ß-isoform of Protein Kinase C with Vimentin Filaments. Cell Motility and the Cytoskeleton 22: 250-257.

7. Meyer, T., 1991. Cell Signaling by Second Messenger Waves. Cell 64: 675-678.

6. Meyer, T. and Stryer, L., 1991. Calcium Spiking. Ann. Rev. Biophys. Biophys. Chem. 20: 153-174.

5. Meyer, T. and Stryer, L., 1990. Transient Calcium Release Induced by Successive Increments of Inositol 1,4,5-trisphosphate. Proc. Natl. Acad. Sci. USA 87: 3841-3845.

4. Meyer, T., Wensel, T. G., and Stryer, L. 1990. Kinetics of Calcium Channel Opening by Inositol 1,4,5-Trisphosphate. Biochemistry 29: 32-37.

3. Meyer, T. and Stryer, L. 1988. Molecular Model for Receptor-Stimulated Calcium Spiking. Proc. Natl. Acad. Sci. USA 85: 5051-5055.

2. Meyer, T., Holowka, D. and Stryer, L. 1988. Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate. Science 240: 653-656

1. Meyer, T. and Schindler, H. G. 1988. Particle Counting by Fluorescence Correlation Spectroscopy: Simultaneous Measurement of Aggregation and Diffusion of Molecules in Solutions and in Membranes. Biophys. J. 54: 983-993