Genes and Cancer
Altered forms of c-Myb
cause leukemias and lymphomas in humans, rodents, and birds.
expression correlates with poor prognosis in breast and other human cancers.
B-Myb is a direct target of the
p16- cyclin D- Rb- E2F pathways that are
mutated in most human cancers.
protein is present in a complex that contains Drosophila RBF
(Drosophila Rb) and E2F2 (Drosophila E2F4/5).