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Sculpture by
Carolyn Chen

Abnormal Mitoses in the Absence of Myb

    Imaginal disc cells from Myb mutant larvae were stained with propidium iodide for DNA (blue), anti-beta-tubulin (green), and anti-phosphohistone H3 for condensed chromatin (red).  Note the mass of condensed DNA that is unattached to the spindle (left) as well as a nucleus with a multipolar spindle (right).

Manak, J., Mitiku, N., and J.S. Lipsick.  "Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability." Proc. Natl. Acad. Sci. USA 99: 7438-7443 (2002). [pdf]